SF3A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000375Biological processRNA splicing, via transesterification reactions
GO_0006397Biological processmRNA processing
GO_0000389Biological processmRNA 3'-splice site recognition
GO_1903241Biological processU2-type prespliceosome assembly
GO_0005686Cellular componentU2 snRNP
GO_0016607Cellular componentnuclear speck
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_0005654Cellular componentnucleoplasm
GO_0005681Cellular componentspliceosomal complex
GO_0071005Cellular componentU2-type precatalytic spliceosome
GO_0005684Cellular componentU2-type spliceosomal complex
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameSF3A3
Protein nameSplicing factor 3A subunit 3 (SF3a60) (Spliceosome-associated protein 61) (SAP 61)
SynonymsSAP61
DescriptionFUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex . Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes . .

AccessionsQ12874
ENST00000373019.5