SF3A2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD8-positive, alpha-beta T cell	19 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	17 studies	26% ± 5%	Explore
regulatory T cell	17 studies	28% ± 6%	Explore
B cell	15 studies	22% ± 5%	Explore
natural killer cell	12 studies	29% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	25% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	27% ± 7%	Explore
memory B cell	10 studies	23% ± 4%	Explore
naive B cell	10 studies	24% ± 5%	Explore
gamma-delta T cell	10 studies	29% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	24% ± 5%	Explore
T cell	9 studies	27% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	23% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	25% ± 4%	Explore
mucosal invariant T cell	8 studies	26% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	26% ± 6%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 6%	Explore
non-classical monocyte	6 studies	23% ± 7%	Explore
endothelial cell	6 studies	25% ± 10%	Explore
plasmablast	5 studies	38% ± 16%	Explore
classical monocyte	5 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	26% ± 6%	Explore
hematopoietic stem cell	5 studies	23% ± 7%	Explore
precursor B cell	5 studies	32% ± 6%	Explore
pro-B cell	5 studies	36% ± 9%	Explore
epithelial cell	5 studies	32% ± 14%	Explore
T follicular helper cell	5 studies	23% ± 3%	Explore
dendritic cell	5 studies	28% ± 12%	Explore
mature NK T cell	5 studies	25% ± 4%	Explore
hematopoietic precursor cell	4 studies	25% ± 10%	Explore
conventional dendritic cell	4 studies	30% ± 14%	Explore
exhausted T cell	4 studies	28% ± 1%	Explore
connective tissue cell	4 studies	26% ± 6%	Explore
myofibroblast cell	4 studies	22% ± 5%	Explore
pericyte	4 studies	24% ± 5%	Explore
smooth muscle cell	4 studies	23% ± 6%	Explore
fibroblast	4 studies	26% ± 6%	Explore
abnormal cell	4 studies	24% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	26% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	27% ± 3%	Explore
erythroblast	3 studies	24% ± 8%	Explore
basal cell	3 studies	30% ± 12%	Explore
immature B cell	3 studies	28% ± 9%	Explore
macrophage	3 studies	17% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	31% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	23% ± 4%	Explore
bone marrow	3 studies	19% ± 3%	Explore
lung	3 studies	20% ± 4%	Explore
lymph node	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4067.49	1445 / 1445	100%	157.78	183 / 183
ovary	100%	7032.27	180 / 180	100%	125.48	430 / 430
uterus	100%	6446.04	170 / 170	100%	120.73	459 / 459
thymus	100%	4157.14	653 / 653	100%	94.81	604 / 605
skin	100%	5020.61	1809 / 1809	99%	110.97	469 / 472
intestine	100%	4398.24	966 / 966	99%	106.44	523 / 527
prostate	100%	4936.81	245 / 245	99%	81.88	498 / 502
stomach	100%	2945.97	359 / 359	99%	118.15	283 / 286
brain	99%	2353.81	2607 / 2642	100%	95.80	705 / 705
breast	100%	4689.40	459 / 459	98%	75.94	1100 / 1118
adrenal gland	100%	2123.76	257 / 258	99%	60.80	227 / 230
bladder	100%	4245.71	21 / 21	98%	97.19	494 / 504
pancreas	100%	2129.50	327 / 328	98%	72.73	175 / 178
kidney	100%	2791.26	89 / 89	98%	54.50	882 / 901
lung	100%	4008.49	577 / 578	98%	80.02	1128 / 1155
liver	99%	1559.62	223 / 226	97%	55.85	392 / 406
adipose	100%	4127.57	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4354.60	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	133.66	80 / 80
lymph node	0%	0	0 / 0	100%	135.59	29 / 29
spleen	100%	4938.20	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	123.55	45 / 45
ureter	0%	0	0 / 0	100%	97.78	1 / 1
muscle	99%	2230.41	798 / 803	0%	0	0 / 0
peripheral blood	99%	4039.83	920 / 929	0%	0	0 / 0
heart	99%	1968.86	852 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0000245	Biological process	spliceosomal complex assembly
GO_0006397	Biological process	mRNA processing
GO_0000389	Biological process	mRNA 3'-splice site recognition
GO_0010976	Biological process	positive regulation of neuron projection development
GO_1903241	Biological process	U2-type prespliceosome assembly
GO_0005686	Cellular component	U2 snRNP
GO_0016607	Cellular component	nuclear speck
GO_0071004	Cellular component	U2-type prespliceosome
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0005681	Cellular component	spliceosomal complex
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005684	Cellular component	U2-type spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

IV. Literature review

[source]

Gene name	SF3A2
Protein name	Splicing factor 3a subunit 2 Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62) SF3A2 protein
Synonyms	SAP62
Description	FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex . Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex . Interacts directly with the duplex formed by U2 snRNA and the intron . .
Accessions	ENST00000221494.10 Q15428 K7EMT0 Q05DF2 ENST00000586396.2

SF3A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review