RPAIN report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
B cell	15 studies	21% ± 6%	Explore
endothelial cell	14 studies	25% ± 9%	Explore
natural killer cell	13 studies	20% ± 4%	Explore
ciliated cell	12 studies	32% ± 16%	Explore
fibroblast	12 studies	22% ± 6%	Explore
regulatory T cell	12 studies	18% ± 4%	Explore
naive B cell	11 studies	19% ± 5%	Explore
pericyte	11 studies	21% ± 5%	Explore
CD4-positive, alpha-beta T cell	10 studies	21% ± 5%	Explore
smooth muscle cell	10 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
neuron	8 studies	43% ± 20%	Explore
epithelial cell	8 studies	43% ± 22%	Explore
basal cell	8 studies	32% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	19% ± 4%	Explore
memory B cell	7 studies	18% ± 2%	Explore
plasmacytoid dendritic cell	7 studies	24% ± 9%	Explore
T cell	6 studies	21% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	18% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	17% ± 1%	Explore
myofibroblast cell	6 studies	23% ± 6%	Explore
precursor B cell	6 studies	29% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	20% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	18% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
mature NK T cell	5 studies	16% ± 0%	Explore
progenitor cell	5 studies	22% ± 8%	Explore
connective tissue cell	5 studies	24% ± 5%	Explore
abnormal cell	5 studies	24% ± 6%	Explore
astrocyte	5 studies	26% ± 5%	Explore
T follicular helper cell	5 studies	16% ± 1%	Explore
GABAergic neuron	5 studies	31% ± 13%	Explore
oligodendrocyte precursor cell	5 studies	32% ± 5%	Explore
gamma-delta T cell	5 studies	28% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	18% ± 4%	Explore
pancreatic A cell	4 studies	33% ± 8%	Explore
enteroendocrine cell	4 studies	33% ± 14%	Explore
mesothelial cell	4 studies	27% ± 15%	Explore
club cell	4 studies	24% ± 7%	Explore
immature B cell	4 studies	27% ± 10%	Explore
type I pneumocyte	4 studies	27% ± 9%	Explore
innate lymphoid cell	4 studies	16% ± 1%	Explore
macrophage	4 studies	21% ± 6%	Explore
endothelial cell of vascular tree	4 studies	17% ± 2%	Explore
glutamatergic neuron	4 studies	43% ± 18%	Explore
goblet cell	4 studies	20% ± 7%	Explore
interneuron	4 studies	28% ± 15%	Explore
hematopoietic precursor cell	3 studies	37% ± 11%	Explore
type B pancreatic cell	3 studies	42% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
leukocyte	3 studies	20% ± 3%	Explore
classical monocyte	3 studies	24% ± 7%	Explore
conventional dendritic cell	3 studies	32% ± 10%	Explore
exhausted T cell	3 studies	23% ± 5%	Explore
non-classical monocyte	3 studies	24% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	25% ± 7%	Explore
endothelial cell of artery	3 studies	17% ± 2%	Explore
neural crest cell	3 studies	26% ± 2%	Explore
capillary endothelial cell	3 studies	19% ± 5%	Explore
endothelial cell of lymphatic vessel	3 studies	23% ± 6%	Explore
pro-B cell	3 studies	28% ± 4%	Explore
type II pneumocyte	3 studies	30% ± 12%	Explore
amacrine cell	3 studies	39% ± 15%	Explore
retina horizontal cell	3 studies	36% ± 16%	Explore
retinal cone cell	3 studies	38% ± 14%	Explore
retinal rod cell	3 studies	24% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	37% ± 21%	Explore
secretory cell	3 studies	32% ± 20%	Explore
oligodendrocyte	3 studies	26% ± 3%	Explore
double negative thymocyte	3 studies	32% ± 22%	Explore
mucosal invariant T cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
lung	8 studies	28% ± 13%	Explore
brain	7 studies	29% ± 12%	Explore
peripheral blood	6 studies	22% ± 8%	Explore
intestine	5 studies	22% ± 9%	Explore
eye	5 studies	27% ± 8%	Explore
pancreas	3 studies	36% ± 2%	Explore
kidney	3 studies	17% ± 2%	Explore
liver	3 studies	29% ± 14%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	1388.62	21 / 21	100%	9.20	503 / 504
ovary	100%	2472.18	180 / 180	100%	7.90	429 / 430
thymus	100%	1761.40	653 / 653	100%	9.59	603 / 605
lung	100%	1534.32	578 / 578	100%	9.38	1151 / 1155
prostate	100%	1808.87	245 / 245	100%	11.48	500 / 502
brain	99%	1332.66	2628 / 2642	100%	16.05	705 / 705
intestine	100%	1544.89	966 / 966	99%	8.08	524 / 527
breast	100%	1861.07	459 / 459	99%	9.18	1111 / 1118
stomach	100%	1268.06	359 / 359	99%	7.14	284 / 286
uterus	100%	1868.18	170 / 170	99%	9.38	455 / 459
esophagus	100%	1372.82	1445 / 1445	99%	6.94	181 / 183
pancreas	100%	1018.03	328 / 328	98%	8.11	175 / 178
skin	100%	1578.87	1809 / 1809	98%	8.90	462 / 472
kidney	100%	1422.83	89 / 89	98%	8.10	881 / 901
adrenal gland	100%	1497.85	258 / 258	96%	8.39	221 / 230
liver	100%	984.06	226 / 226	91%	4.70	371 / 406
adipose	100%	1624.68	1204 / 1204	0%	0	0 / 0
blood vessel	100%	1442.73	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	10.47	29 / 29
spleen	100%	1614.17	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	4.80	1 / 1
muscle	100%	1321.24	802 / 803	0%	0	0 / 0
heart	98%	1116.11	848 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	8.25	44 / 45
eye	0%	0	0 / 0	96%	7.12	77 / 80
peripheral blood	80%	800.88	742 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0