RO60 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	26 studies	25% ± 10%	Explore
natural killer cell	22 studies	22% ± 6%	Explore
fibroblast	19 studies	25% ± 9%	Explore
pericyte	19 studies	21% ± 5%	Explore
smooth muscle cell	16 studies	22% ± 5%	Explore
endothelial cell of lymphatic vessel	11 studies	23% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	27% ± 5%	Explore
CD8-positive, alpha-beta T cell	10 studies	22% ± 6%	Explore
capillary endothelial cell	10 studies	18% ± 2%	Explore
connective tissue cell	10 studies	23% ± 7%	Explore
B cell	9 studies	21% ± 5%	Explore
mature NK T cell	9 studies	19% ± 3%	Explore
myofibroblast cell	9 studies	26% ± 5%	Explore
regulatory T cell	9 studies	20% ± 4%	Explore
astrocyte	8 studies	32% ± 11%	Explore
oligodendrocyte	8 studies	27% ± 9%	Explore
gamma-delta T cell	8 studies	24% ± 9%	Explore
plasmacytoid dendritic cell	8 studies	21% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 3%	Explore
retinal rod cell	7 studies	31% ± 11%	Explore
endothelial cell of vascular tree	7 studies	19% ± 3%	Explore
vein endothelial cell	7 studies	17% ± 2%	Explore
oligodendrocyte precursor cell	7 studies	30% ± 11%	Explore
T cell	6 studies	19% ± 3%	Explore
mast cell	6 studies	20% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 2%	Explore
neuron	6 studies	29% ± 13%	Explore
epithelial cell	6 studies	34% ± 15%	Explore
basal cell	6 studies	25% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	21% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	22% ± 3%	Explore
CD4-positive, alpha-beta T cell	5 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 6%	Explore
retinal cone cell	5 studies	42% ± 18%	Explore
endothelial cell of artery	5 studies	19% ± 2%	Explore
GABAergic neuron	5 studies	40% ± 13%	Explore
mucosal invariant T cell	5 studies	18% ± 2%	Explore
interneuron	5 studies	34% ± 20%	Explore
memory B cell	5 studies	19% ± 2%	Explore
naive B cell	4 studies	20% ± 4%	Explore
retina horizontal cell	4 studies	24% ± 6%	Explore
ciliated cell	4 studies	28% ± 7%	Explore
Mueller cell	4 studies	36% ± 10%	Explore
glutamatergic neuron	4 studies	53% ± 12%	Explore
classical monocyte	3 studies	24% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	20% ± 3%	Explore
non-classical monocyte	3 studies	24% ± 8%	Explore
conventional dendritic cell	3 studies	24% ± 11%	Explore
exhausted T cell	3 studies	21% ± 5%	Explore
glomerular endothelial cell	3 studies	22% ± 1%	Explore
neural crest cell	3 studies	20% ± 3%	Explore
precursor B cell	3 studies	21% ± 1%	Explore
lymphocyte	3 studies	23% ± 4%	Explore
secretory cell	3 studies	25% ± 8%	Explore
abnormal cell	3 studies	39% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 9%	Explore
innate lymphoid cell	3 studies	17% ± 1%	Explore
type I pneumocyte	3 studies	21% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	22% ± 9%	Explore
macrophage	3 studies	22% ± 2%	Explore
goblet cell	3 studies	26% ± 8%	Explore
double negative thymocyte	3 studies	31% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	22% ± 7%	Explore
lung	8 studies	24% ± 8%	Explore
eye	8 studies	28% ± 11%	Explore
brain	7 studies	37% ± 15%	Explore
bone marrow	4 studies	16% ± 1%	Explore
kidney	3 studies	18% ± 1%	Explore
intestine	3 studies	23% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1816.46	1445 / 1445	100%	17.07	183 / 183
ovary	100%	2257.67	180 / 180	100%	10.47	429 / 430
lung	100%	1981.70	578 / 578	100%	16.03	1150 / 1155
brain	100%	1360.53	2639 / 2642	100%	21.85	702 / 705
breast	100%	2004.46	459 / 459	99%	23.84	1105 / 1118
stomach	100%	1172.69	359 / 359	97%	11.39	277 / 286
prostate	100%	1698.86	245 / 245	96%	15.08	483 / 502
intestine	100%	1773.05	966 / 966	96%	8.96	507 / 527
pancreas	99%	829.84	325 / 328	97%	9.76	172 / 178
uterus	100%	2246.88	170 / 170	94%	11.82	432 / 459
skin	100%	1953.06	1808 / 1809	92%	19.46	433 / 472
bladder	100%	1828.10	21 / 21	91%	10.16	457 / 504
thymus	100%	1703.84	652 / 653	90%	9.64	546 / 605
kidney	100%	1022.26	89 / 89	89%	12.29	802 / 901
adrenal gland	100%	1646.23	258 / 258	87%	8.18	201 / 230
liver	100%	758.07	226 / 226	79%	6.91	321 / 406
adipose	100%	2140.24	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2024.63	1335 / 1335	0%	0	0 / 0
muscle	100%	1229.32	803 / 803	0%	0	0 / 0
spleen	100%	1434.86	241 / 241	0%	0	0 / 0
heart	98%	1233.85	846 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	10.73	42 / 45
lymph node	0%	0	0 / 0	90%	10.07	26 / 29
peripheral blood	85%	1349.06	789 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	60%	4.87	48 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0060271	Biological process	cilium assembly
GO_0002520	Biological process	immune system development
GO_0010468	Biological process	regulation of gene expression
GO_0007224	Biological process	smoothened signaling pathway
GO_0009411	Biological process	response to UV
GO_0035457	Biological process	cellular response to interferon-alpha
GO_0006383	Biological process	transcription by RNA polymerase III
GO_0016604	Cellular component	nuclear body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0030620	Molecular function	U2 snRNA binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	RO60
Protein name	Ro60, Y RNA binding protein (TROVE domain family, member 2, isoform CRA_a) Ro60, Y RNA binding protein RNA-binding protein RO60 (60 kDa SS-A/Ro ribonucleoprotein) (60 kDa Ro protein) (60 kDa ribonucleoprotein Ro) (RoRNP) (Ro 60 kDa autoantigen) (Ro60 autoantigen) (Sjoegren syndrome antigen A2) (Sjoegren syndrome type A antigen) (SS-A) (TROVE domain family member 2)
Synonyms	hCG_41054 SSA2 TROVE2
Description	FUNCTION: RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs . Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion . Regulates the expression of Alu retroelements as well as inflammatory genes . May play roles in cilia formation and/or maintenance (By similarity). .
Accessions	ENST00000367441.1 [P10155-1] ENST00000506303.1 ENST00000367444.7 [P10155-5] P10155 D6RE09 ENST00000367445.7 [P10155-4] ENST00000415442.2 D6RDN1 G5E9R9 ENST00000512587.1 ENST00000400968.7 [P10155-1] ENST00000367446.7 [P10155-1] ENST00000432079.5 H0Y9N5 ENST00000367443.5 [P10155-3]

RO60 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review