RIOK3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
classical monocyte	21 studies	31% ± 14%	Explore
natural killer cell	20 studies	26% ± 9%	Explore
non-classical monocyte	20 studies	35% ± 17%	Explore
macrophage	17 studies	22% ± 7%	Explore
endothelial cell	16 studies	26% ± 8%	Explore
B cell	15 studies	23% ± 5%	Explore
monocyte	13 studies	26% ± 9%	Explore
basal cell	13 studies	31% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	30% ± 9%	Explore
naive B cell	12 studies	21% ± 5%	Explore
epithelial cell	11 studies	41% ± 21%	Explore
erythrocyte	10 studies	37% ± 18%	Explore
platelet	10 studies	37% ± 12%	Explore
fibroblast	9 studies	23% ± 8%	Explore
ciliated cell	9 studies	32% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	31% ± 10%	Explore
CD8-positive, alpha-beta T cell	9 studies	24% ± 6%	Explore
regulatory T cell	9 studies	23% ± 7%	Explore
type I pneumocyte	8 studies	25% ± 5%	Explore
secretory cell	8 studies	29% ± 15%	Explore
mature NK T cell	8 studies	21% ± 4%	Explore
memory B cell	8 studies	21% ± 4%	Explore
T cell	7 studies	23% ± 6%	Explore
respiratory goblet cell	7 studies	22% ± 5%	Explore
plasmacytoid dendritic cell	7 studies	20% ± 4%	Explore
myeloid cell	7 studies	25% ± 12%	Explore
oligodendrocyte	7 studies	25% ± 8%	Explore
gamma-delta T cell	7 studies	27% ± 7%	Explore
alveolar macrophage	6 studies	23% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	23% ± 6%	Explore
conventional dendritic cell	6 studies	32% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	22% ± 5%	Explore
goblet cell	6 studies	31% ± 19%	Explore
dendritic cell	6 studies	32% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	22% ± 6%	Explore
microglial cell	5 studies	23% ± 5%	Explore
lymphocyte	5 studies	23% ± 9%	Explore
mucosal invariant T cell	5 studies	21% ± 3%	Explore
enterocyte	5 studies	29% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	28% ± 8%	Explore
adipocyte	5 studies	23% ± 3%	Explore
GABAergic neuron	5 studies	33% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 4%	Explore
mast cell	4 studies	17% ± 2%	Explore
endothelial cell of lymphatic vessel	4 studies	21% ± 4%	Explore
smooth muscle cell	4 studies	16% ± 0%	Explore
type II pneumocyte	4 studies	19% ± 3%	Explore
squamous epithelial cell	4 studies	64% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
plasmablast	4 studies	40% ± 12%	Explore
club cell	4 studies	26% ± 9%	Explore
retinal cone cell	4 studies	20% ± 2%	Explore
astrocyte	4 studies	28% ± 6%	Explore
glutamatergic neuron	4 studies	46% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	22% ± 3%	Explore
leukocyte	3 studies	22% ± 4%	Explore
megakaryocyte	3 studies	51% ± 14%	Explore
immature B cell	3 studies	25% ± 3%	Explore
intermediate monocyte	3 studies	47% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 7%	Explore
innate lymphoid cell	3 studies	22% ± 3%	Explore
hepatocyte	3 studies	34% ± 21%	Explore
oligodendrocyte precursor cell	3 studies	30% ± 7%	Explore
pancreatic A cell	3 studies	29% ± 9%	Explore
abnormal cell	3 studies	25% ± 6%	Explore
keratinocyte	3 studies	25% ± 6%	Explore
interneuron	3 studies	36% ± 17%	Explore
neuron	3 studies	29% ± 8%	Explore
double negative thymocyte	3 studies	32% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	19% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	28% ± 9%	Explore
lung	7 studies	32% ± 16%	Explore
brain	6 studies	35% ± 12%	Explore
intestine	4 studies	18% ± 1%	Explore
placenta	3 studies	27% ± 5%	Explore
bone marrow	3 studies	19% ± 2%	Explore
liver	3 studies	27% ± 7%	Explore
adipose	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	5212.81	21 / 21	100%	54.39	504 / 504
esophagus	100%	6978.26	1445 / 1445	100%	98.69	183 / 183
ovary	100%	3642.24	180 / 180	100%	37.80	430 / 430
pancreas	100%	3074.11	328 / 328	100%	80.25	178 / 178
uterus	100%	3926.17	170 / 170	100%	67.60	458 / 459
lung	100%	5279.91	577 / 578	100%	69.45	1154 / 1155
breast	100%	4673.85	459 / 459	100%	50.12	1115 / 1118
thymus	100%	4258.81	652 / 653	100%	49.01	604 / 605
stomach	100%	3420.64	359 / 359	100%	49.56	285 / 286
prostate	100%	4018.94	245 / 245	100%	44.26	500 / 502
liver	100%	3909.37	226 / 226	100%	37.86	404 / 406
intestine	100%	5037.78	966 / 966	99%	53.72	524 / 527
kidney	100%	3340.27	89 / 89	99%	55.53	890 / 901
adrenal gland	100%	3459.31	258 / 258	95%	30.37	219 / 230
brain	94%	2010.13	2489 / 2642	100%	35.53	705 / 705
skin	100%	6553.03	1809 / 1809	93%	36.94	441 / 472
adipose	100%	4934.82	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	47.46	29 / 29
muscle	100%	7181.90	803 / 803	0%	0	0 / 0
spleen	100%	3969.05	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	78.69	45 / 45
ureter	0%	0	0 / 0	100%	24.51	1 / 1
blood vessel	100%	4625.99	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	6644.40	926 / 929	0%	0	0 / 0
heart	95%	3064.77	816 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	68%	14.47	54 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032728	Biological process	positive regulation of interferon-beta production
GO_0007059	Biological process	chromosome segregation
GO_1990786	Biological process	cellular response to dsDNA
GO_0045087	Biological process	innate immune response
GO_0051607	Biological process	defense response to virus
GO_0071359	Biological process	cellular response to dsRNA
GO_0031333	Biological process	negative regulation of protein-containing complex assembly
GO_0039534	Biological process	negative regulation of MDA-5 signaling pathway
GO_0045089	Biological process	positive regulation of innate immune response
GO_0098586	Biological process	cellular response to virus
GO_0030490	Biological process	maturation of SSU-rRNA
GO_0043124	Biological process	negative regulation of canonical NF-kappaB signal transduction
GO_0030688	Cellular component	preribosome, small subunit precursor
GO_0005829	Cellular component	cytosol
GO_0106310	Molecular function	protein serine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0089720	Molecular function	caspase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RIOK3
Protein name	Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog) Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) RIO kinase 3
Synonyms	SUDD hCG_37755
Description	FUNCTION: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 . Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling . Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway . May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA . . FUNCTION: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. . FUNCTION: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. . FUNCTION: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. .
Accessions	B4E1Q4 J3QQL5 J3QLP4 ENST00000584130.1 O14730 ENST00000581585.5 ENST00000577501.5 [O14730-2] ENST00000339486.8 [O14730-1] I6L994 ENST00000577250.1 B0YJ89

RIOK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review