RESF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	33% ± 12%	Explore
CD8-positive, alpha-beta T cell	33 studies	37% ± 12%	Explore
natural killer cell	32 studies	29% ± 10%	Explore
T cell	27 studies	34% ± 13%	Explore
CD4-positive, alpha-beta T cell	27 studies	36% ± 11%	Explore
regulatory T cell	24 studies	39% ± 11%	Explore
endothelial cell	23 studies	25% ± 10%	Explore
memory B cell	18 studies	38% ± 10%	Explore
mature NK T cell	17 studies	33% ± 10%	Explore
gamma-delta T cell	16 studies	38% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	38% ± 10%	Explore
classical monocyte	16 studies	22% ± 7%	Explore
naive B cell	16 studies	34% ± 11%	Explore
macrophage	14 studies	27% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	30% ± 8%	Explore
mucosal invariant T cell	13 studies	39% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	38% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	33% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	46% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	43% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	40% ± 13%	Explore
neutrophil	9 studies	36% ± 11%	Explore
monocyte	9 studies	26% ± 8%	Explore
non-classical monocyte	8 studies	23% ± 8%	Explore
secretory cell	8 studies	26% ± 8%	Explore
innate lymphoid cell	7 studies	28% ± 9%	Explore
plasmacytoid dendritic cell	7 studies	21% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	33% ± 11%	Explore
T follicular helper cell	7 studies	47% ± 14%	Explore
leukocyte	6 studies	34% ± 11%	Explore
myeloid cell	6 studies	29% ± 8%	Explore
epithelial cell	6 studies	42% ± 19%	Explore
dendritic cell	6 studies	28% ± 11%	Explore
microglial cell	6 studies	33% ± 10%	Explore
oligodendrocyte	6 studies	21% ± 5%	Explore
CD4-positive helper T cell	5 studies	36% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	44% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	39% ± 11%	Explore
exhausted T cell	5 studies	44% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	39% ± 13%	Explore
conventional dendritic cell	5 studies	25% ± 10%	Explore
plasma cell	4 studies	24% ± 7%	Explore
plasmablast	4 studies	23% ± 3%	Explore
capillary endothelial cell	4 studies	19% ± 4%	Explore
mononuclear phagocyte	4 studies	26% ± 6%	Explore
lymphocyte	4 studies	54% ± 9%	Explore
basal cell	4 studies	22% ± 6%	Explore
endothelial cell of vascular tree	4 studies	24% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	47% ± 5%	Explore
GABAergic neuron	4 studies	33% ± 12%	Explore
astrocyte	4 studies	27% ± 7%	Explore
glutamatergic neuron	4 studies	39% ± 15%	Explore
pericyte	4 studies	19% ± 4%	Explore
double negative thymocyte	4 studies	40% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	29% ± 12%	Explore
squamous epithelial cell	3 studies	43% ± 20%	Explore
erythrocyte	3 studies	27% ± 5%	Explore
glomerular endothelial cell	3 studies	38% ± 3%	Explore
immature B cell	3 studies	20% ± 3%	Explore
intermediate monocyte	3 studies	33% ± 21%	Explore
vein endothelial cell	3 studies	23% ± 10%	Explore
hepatocyte	3 studies	21% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	31% ± 10%	Explore
endothelial cell of lymphatic vessel	3 studies	19% ± 2%	Explore
T-helper 17 cell	3 studies	33% ± 2%	Explore
smooth muscle cell	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	31% ± 8%	Explore
lung	6 studies	24% ± 9%	Explore
liver	5 studies	29% ± 4%	Explore
brain	4 studies	37% ± 5%	Explore
bone marrow	3 studies	27% ± 5%	Explore
intestine	3 studies	18% ± 1%	Explore
uterus	3 studies	32% ± 16%	Explore
adipose	3 studies	24% ± 5%	Explore
lymph node	3 studies	32% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2089.89	1443 / 1445	100%	51.51	183 / 183
ovary	100%	11566.67	180 / 180	100%	66.34	429 / 430
lung	100%	4571.53	578 / 578	99%	31.53	1143 / 1155
breast	100%	3144.24	459 / 459	98%	38.40	1099 / 1118
thymus	100%	3321.67	653 / 653	97%	23.62	586 / 605
stomach	99%	2016.53	357 / 359	97%	34.06	276 / 286
intestine	100%	3284.21	965 / 966	95%	26.95	502 / 527
pancreas	96%	1238.23	316 / 328	98%	36.98	174 / 178
uterus	100%	4138.04	170 / 170	94%	24.36	431 / 459
bladder	100%	3318.24	21 / 21	92%	20.61	462 / 504
prostate	100%	2744.27	245 / 245	87%	14.95	437 / 502
skin	100%	1858.57	1804 / 1809	86%	24.76	406 / 472
kidney	100%	2359.25	89 / 89	85%	22.79	769 / 901
liver	100%	3239.95	226 / 226	78%	14.44	315 / 406
brain	90%	980.44	2383 / 2642	85%	11.09	597 / 705
adrenal gland	100%	1752.17	257 / 258	64%	7.46	148 / 230
lymph node	0%	0	0 / 0	100%	62.90	29 / 29
spleen	100%	9645.74	241 / 241	0%	0	0 / 0
adipose	100%	3674.78	1203 / 1204	0%	0	0 / 0
blood vessel	100%	2449.75	1333 / 1335	0%	0	0 / 0
peripheral blood	99%	9007.14	919 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	30.37	44 / 45
heart	97%	1311.20	837 / 861	0%	0	0 / 0
muscle	86%	780.92	687 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	40%	5.04	32 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0090309	Biological process	positive regulation of DNA methylation-dependent heterochromatin formation
GO_0045869	Biological process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0000930	Cellular component	gamma-tubulin complex
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_1990226	Molecular function	histone methyltransferase binding
GO_0042393	Molecular function	histone binding

IV. Literature review

[source]

Gene name	RESF1
Protein name	Retroelement silencing factor 1
Synonyms	KIAA1551 C12orf35
Description	FUNCTION: Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. .
Accessions	J3KPI3 ENST00000540924.5 Q9HCM1 F5H488 ENST00000381054.3 ENST00000312561.9

RESF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review