RC3H1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043029Biological processT cell homeostasis
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0000209Biological processprotein polyubiquitination
GO_0043488Biological processregulation of mRNA stability
GO_0042098Biological processT cell proliferation
GO_0048535Biological processlymph node development
GO_0002634Biological processregulation of germinal center formation
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0071347Biological processcellular response to interleukin-1
GO_0033962Biological processP-body assembly
GO_0001782Biological processB cell homeostasis
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0002635Biological processnegative regulation of germinal center formation
GO_0050852Biological processT cell receptor signaling pathway
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0048536Biological processspleen development
GO_2000320Biological processnegative regulation of T-helper 17 cell differentiation
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0061470Biological processT follicular helper cell differentiation
GO_2000628Biological processregulation of miRNA metabolic process
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0050856Biological processregulation of T cell receptor signaling pathway
GO_1900151Biological processregulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0000956Biological processnuclear-transcribed mRNA catabolic process
GO_0045623Biological processnegative regulation of T-helper cell differentiation
GO_0030889Biological processnegative regulation of B cell proliferation
GO_0000932Cellular componentP-body
GO_0010494Cellular componentcytoplasmic stress granule
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0003729Molecular functionmRNA binding
GO_1905762Molecular functionCCR4-NOT complex binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0035198Molecular functionmiRNA binding
GO_0035613Molecular functionRNA stem-loop binding
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameRC3H1
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)
SynonymsKIAA2025
RNF198
DescriptionFUNCTION: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs . Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (By similarity). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (By similarity). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (By similarity). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (By similarity). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). Recognizes and binds mRNAs containing a hexaloop stem-loop motif, called alternative decay element (ADE) (By similarity). Together with ZC3H12A, destabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR (By similarity). Able to interact with double-stranded RNA (dsRNA) . miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression . Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2A, UBE2B, UBE2D2, UBE2F, UBE2G1, UBE2G2 and UBE2L3 and produces polyubiquitin chains . Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains . .

AccessionsQ5TC82
ENST00000367696.7 [Q5TC82-1]
ENST00000258349.8 [Q5TC82-1]
B7ZMB3
ENST00000367694.2 [Q5TC82-2]
B9EGU6