RBM4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031016Biological processpancreas development
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0006396Biological processRNA processing
GO_0032055Biological processnegative regulation of translation in response to stress
GO_0051149Biological processpositive regulation of muscle cell differentiation
GO_0035883Biological processenteroendocrine cell differentiation
GO_0002190Biological processcap-independent translational initiation
GO_0046685Biological processresponse to arsenic-containing substance
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0032922Biological processcircadian regulation of gene expression
GO_0035773Biological processinsulin secretion involved in cellular response to glucose stimulus
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0046822Biological processregulation of nucleocytoplasmic transport
GO_0002192Biological processIRES-dependent translational initiation of linear mRNA
GO_0045947Biological processnegative regulation of translational initiation
GO_0045727Biological processpositive regulation of translation
GO_0097167Biological processcircadian regulation of translation
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0046626Biological processregulation of insulin receptor signaling pathway
GO_0017148Biological processnegative regulation of translation
GO_0005730Cellular componentnucleolus
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0097157Molecular functionpre-mRNA intronic binding
GO_0003729Molecular functionmRNA binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding
GO_0097158Molecular functionpre-mRNA intronic pyrimidine-rich binding

IV. Literature review

[source]
Gene nameRBM4
Protein nameRNA binding motif protein 4
RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)
SynonymsRBM4A
DescriptionFUNCTION: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. .

AccessionsENST00000510173.6
ENST00000310092.12 [Q9BWF3-1]
E9PB51
ENST00000409406.1 [Q9BWF3-1]
ENST00000398692.8 [Q9BWF3-3]
ENST00000408993.6 [Q9BWF3-1]
Q9BWF3
D6R9K7
ENST00000506523.6
ENST00000532968.1 [Q9BWF3-2]
ENST00000530235.1 [Q9BWF3-3]
J3QRR5
ENST00000483858.5 [Q9BWF3-2]
ENST00000578778.5
ENST00000396053.9 [Q9BWF3-4]