RASSF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007265Biological processRas protein signal transduction
GO_0005813Cellular componentcentrosome
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameRASSF1
Protein nameRas association (RalGDS/AF-6) domain family member 1
RASSF1
Ras association domain-containing protein 1
SynonymsRDA32
DescriptionFUNCTION: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. .

AccessionsENST00000482447.1 [Q9NS23-7]
Q1W2K8
Q9NS23
ENST00000357043.6 [Q9NS23-1]
ENST00000616212.4 [Q9NS23-3]
ENST00000327761.7 [Q9NS23-4]
ENST00000395126.7 [Q9NS23-3]
Q17RX7
ENST00000395117.6 [Q9NS23-6]
ENST00000359365.9 [Q9NS23-2]