PUM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035196Biological processmiRNA processing
GO_0034063Biological processstress granule assembly
GO_0043488Biological processregulation of mRNA stability
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0006417Biological processregulation of translation
GO_1900246Biological processpositive regulation of RIG-I signaling pathway
GO_0007005Biological processmitochondrion organization
GO_0051276Biological processchromosome organization
GO_1904580Biological processregulation of intracellular mRNA localization
GO_0051983Biological processregulation of chromosome segregation
GO_0022904Biological processrespiratory electron transport chain
GO_0001942Biological processhair follicle development
GO_0060612Biological processadipose tissue development
GO_0001501Biological processskeletal system development
GO_0060964Biological processregulation of miRNA-mediated gene silencing
GO_0048687Biological processpositive regulation of sprouting of injured axon
GO_2000637Biological processpositive regulation of miRNA-mediated gene silencing
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0043025Cellular componentneuronal cell body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0010494Cellular componentcytoplasmic stress granule
GO_0106222Molecular functionlncRNA binding
GO_0003723Molecular functionRNA binding
GO_0062104Molecular functionpumilio-response element binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0035198Molecular functionmiRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePUM2
Protein namePUM2 protein (Pumilio homolog 2 (Drosophila), isoform CRA_b)
Pumilio RNA binding family member 2
Pumilio homolog 2 (Pumilio-2)
SynonymsKIAA0235
hCG_32092
PUMH2
DescriptionFUNCTION: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation . Also mediates deadenylation-independent repression by promoting accessibility of miRNAs . Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation . Plays a role in cytoplasmic sensing of viral infection . Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm . May regulate DCUN1D3 mRNA levels . May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level . .

AccessionsF2Z366
ENST00000429419.6
ENST00000442400.5
ENST00000338086.9 [Q8TB72-3]
ENST00000446940.5
C9JW01
F8WD57
ENST00000440577.5
Q8TB72
C9JE24
ENST00000361078.7 [Q8TB72-3]
B7ZL34
ENST00000424110.1
ENST00000704930.1 [Q8TB72-1]
A0A0C4DG68
ENST00000432105.5