PSPC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140694Biological processnon-membrane-bounded organelle assembly
GO_0002218Biological processactivation of innate immune response
GO_0048511Biological processrhythmic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0042752Biological processregulation of circadian rhythm
GO_0045087Biological processinnate immune response
GO_0042382Cellular componentparaspeckles
GO_0016363Cellular componentnuclear matrix
GO_0016607Cellular componentnuclear speck
GO_0001650Cellular componentfibrillar center
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePSPC1
Protein nameParaspeckle component 1
Paraspeckle component 1 (Paraspeckle protein 1)
SynonymsPSP1
DescriptionFUNCTION: Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. .

AccessionsENST00000338910.9 [Q8WXF1-1]
ENST00000492741.5 [Q8WXF1-2]
Q8WXF1
ENST00000427943.1
ENST00000471658.5 [Q8WXF1-2]
ENST00000619300.4 [Q8WXF1-1]
ENST00000635562.1
X6RDA4
A0A0U1RQF9