PSMD11 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	18 studies	26% ± 8%	Explore
natural killer cell	14 studies	21% ± 6%	Explore
fibroblast	14 studies	23% ± 8%	Explore
regulatory T cell	13 studies	24% ± 8%	Explore
macrophage	11 studies	21% ± 6%	Explore
basal cell	10 studies	27% ± 12%	Explore
smooth muscle cell	10 studies	20% ± 4%	Explore
CD8-positive, alpha-beta T cell	10 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	9 studies	29% ± 12%	Explore
pericyte	9 studies	20% ± 3%	Explore
epithelial cell	9 studies	34% ± 18%	Explore
endothelial cell of vascular tree	8 studies	21% ± 5%	Explore
oligodendrocyte	8 studies	24% ± 6%	Explore
monocyte	7 studies	18% ± 3%	Explore
classical monocyte	7 studies	25% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	19% ± 2%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	20% ± 3%	Explore
gamma-delta T cell	7 studies	23% ± 14%	Explore
plasmacytoid dendritic cell	7 studies	21% ± 6%	Explore
endothelial cell of lymphatic vessel	6 studies	21% ± 6%	Explore
T cell	6 studies	18% ± 3%	Explore
naive B cell	6 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	18% ± 3%	Explore
B cell	6 studies	21% ± 5%	Explore
mature NK T cell	6 studies	16% ± 1%	Explore
connective tissue cell	6 studies	18% ± 3%	Explore
glutamatergic neuron	6 studies	40% ± 24%	Explore
astrocyte	6 studies	30% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	21% ± 6%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 7%	Explore
plasma cell	5 studies	31% ± 14%	Explore
plasmablast	5 studies	42% ± 22%	Explore
secretory cell	5 studies	25% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	16% ± 1%	Explore
non-classical monocyte	5 studies	26% ± 9%	Explore
conventional dendritic cell	5 studies	30% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
neuron	5 studies	28% ± 12%	Explore
myofibroblast cell	5 studies	20% ± 3%	Explore
ciliated cell	5 studies	32% ± 11%	Explore
capillary endothelial cell	5 studies	21% ± 5%	Explore
endothelial cell of artery	5 studies	18% ± 3%	Explore
abnormal cell	5 studies	21% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	22% ± 7%	Explore
hematopoietic precursor cell	4 studies	23% ± 9%	Explore
pancreatic A cell	4 studies	37% ± 11%	Explore
exhausted T cell	4 studies	24% ± 7%	Explore
lymphocyte	4 studies	22% ± 5%	Explore
precursor B cell	4 studies	25% ± 7%	Explore
vein endothelial cell	4 studies	22% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	24% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	31% ± 8%	Explore
memory B cell	4 studies	23% ± 11%	Explore
type I pneumocyte	4 studies	25% ± 7%	Explore
GABAergic neuron	4 studies	43% ± 17%	Explore
interneuron	4 studies	36% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	23% ± 5%	Explore
type B pancreatic cell	3 studies	48% ± 17%	Explore
epithelial cell of proximal tubule	3 studies	18% ± 1%	Explore
neural crest cell	3 studies	17% ± 2%	Explore
microglial cell	3 studies	17% ± 1%	Explore
placental villous trophoblast	3 studies	42% ± 8%	Explore
innate lymphoid cell	3 studies	17% ± 2%	Explore
club cell	3 studies	26% ± 12%	Explore
erythroblast	3 studies	31% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 5%	Explore
dendritic cell	3 studies	40% ± 17%	Explore
pancreatic ductal cell	3 studies	53% ± 19%	Explore
goblet cell	3 studies	22% ± 4%	Explore
intestinal crypt stem cell	3 studies	20% ± 3%	Explore
transit amplifying cell	3 studies	26% ± 8%	Explore
adipocyte	3 studies	17% ± 2%	Explore
double negative thymocyte	3 studies	27% ± 13%	Explore
mucosal invariant T cell	3 studies	19% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	8 studies	22% ± 5%	Explore
lung	7 studies	27% ± 12%	Explore
brain	7 studies	34% ± 15%	Explore
pancreas	3 studies	45% ± 11%	Explore
placenta	3 studies	22% ± 5%	Explore
eye	3 studies	24% ± 6%	Explore
intestine	3 studies	23% ± 8%	Explore
liver	3 studies	34% ± 18%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4798.73	1445 / 1445	100%	86.64	183 / 183
intestine	100%	4559.68	966 / 966	100%	52.19	527 / 527
liver	100%	3327.12	226 / 226	100%	34.36	406 / 406
lung	100%	4917.92	578 / 578	100%	70.69	1155 / 1155
ovary	100%	3846.47	180 / 180	100%	32.96	430 / 430
skin	100%	6133.26	1809 / 1809	100%	53.22	472 / 472
stomach	100%	3337.42	359 / 359	100%	53.16	286 / 286
uterus	100%	4647.14	170 / 170	100%	63.96	459 / 459
breast	100%	4365.19	459 / 459	100%	58.84	1117 / 1118
bladder	100%	4630.81	21 / 21	100%	63.79	503 / 504
prostate	100%	4139.35	245 / 245	100%	43.58	501 / 502
brain	100%	3442.40	2632 / 2642	100%	41.04	705 / 705
thymus	100%	3970.38	652 / 653	100%	33.83	603 / 605
kidney	100%	3611.93	89 / 89	99%	33.55	893 / 901
pancreas	100%	2291.94	327 / 328	99%	41.89	176 / 178
adrenal gland	100%	4574.22	258 / 258	96%	24.75	221 / 230
adipose	100%	4764.94	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4141.17	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	53.40	29 / 29
muscle	100%	10258.60	803 / 803	0%	0	0 / 0
spleen	100%	4463.86	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	66.93	45 / 45
ureter	0%	0	0 / 0	100%	34.17	1 / 1
heart	99%	3734.64	850 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	30.09	78 / 80
peripheral blood	92%	3015.37	858 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0043248	Biological process	proteasome assembly
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0048863	Biological process	stem cell differentiation
GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0034774	Cellular component	secretory granule lumen
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005576	Cellular component	extracellular region
GO_0008541	Cellular component	proteasome regulatory particle, lid subcomplex
GO_0022624	Cellular component	proteasome accessory complex
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0005198	Molecular function	structural molecule activity

IV. Literature review

[source]

Gene name	PSMD11
Protein name	26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) (26S proteasome regulatory subunit S9) (26S proteasome regulatory subunit p44.5) Proteasome 26S subunit, non-ATPase 11
Synonyms
Description	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. .
Accessions	ENST00000578213.5 J3QS13 ENST00000261712.8 [O00231-1] O00231 J3KSW3 ENST00000579451.1 ENST00000457654.6 [O00231-1] ENST00000649012.1 [O00231-1] J3QRY4 ENST00000584340.1

PSMD11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review