PMPCB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	18 studies	19% ± 4%	Explore
B cell	16 studies	22% ± 5%	Explore
CD4-positive, alpha-beta T cell	15 studies	21% ± 5%	Explore
regulatory T cell	15 studies	20% ± 4%	Explore
memory B cell	14 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	13 studies	20% ± 5%	Explore
naive B cell	11 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	21% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	20% ± 3%	Explore
fibroblast	9 studies	21% ± 6%	Explore
endothelial cell	9 studies	25% ± 6%	Explore
plasmacytoid dendritic cell	9 studies	22% ± 7%	Explore
gamma-delta T cell	9 studies	24% ± 14%	Explore
T cell	8 studies	19% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	20% ± 3%	Explore
mucosal invariant T cell	8 studies	20% ± 2%	Explore
epithelial cell	8 studies	34% ± 16%	Explore
smooth muscle cell	7 studies	20% ± 3%	Explore
pericyte	7 studies	18% ± 3%	Explore
basal cell	6 studies	27% ± 11%	Explore
ciliated cell	6 studies	25% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	21% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
mature NK T cell	5 studies	17% ± 2%	Explore
myofibroblast cell	5 studies	18% ± 2%	Explore
abnormal cell	5 studies	25% ± 7%	Explore
precursor B cell	5 studies	27% ± 8%	Explore
oligodendrocyte precursor cell	5 studies	27% ± 9%	Explore
oligodendrocyte	5 studies	24% ± 6%	Explore
conventional dendritic cell	4 studies	29% ± 11%	Explore
exhausted T cell	4 studies	20% ± 6%	Explore
renal alpha-intercalated cell	4 studies	35% ± 7%	Explore
epithelial cell of proximal tubule	4 studies	17% ± 1%	Explore
hematopoietic stem cell	4 studies	25% ± 7%	Explore
pro-B cell	4 studies	26% ± 4%	Explore
immature B cell	4 studies	19% ± 3%	Explore
T follicular helper cell	4 studies	20% ± 1%	Explore
astrocyte	4 studies	28% ± 4%	Explore
goblet cell	4 studies	21% ± 3%	Explore
mast cell	4 studies	21% ± 7%	Explore
neuron	4 studies	28% ± 9%	Explore
hematopoietic precursor cell	3 studies	37% ± 13%	Explore
plasmablast	3 studies	50% ± 8%	Explore
classical monocyte	3 studies	23% ± 4%	Explore
non-classical monocyte	3 studies	29% ± 7%	Explore
connective tissue cell	3 studies	20% ± 3%	Explore
plasma cell	3 studies	29% ± 12%	Explore
germinal center B cell	3 studies	24% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	23% ± 2%	Explore
macrophage	3 studies	19% ± 1%	Explore
GABAergic neuron	3 studies	43% ± 3%	Explore
glutamatergic neuron	3 studies	56% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 7%	Explore
intestinal crypt stem cell	3 studies	20% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 8%	Explore
interneuron	3 studies	37% ± 19%	Explore
innate lymphoid cell	3 studies	19% ± 1%	Explore
double negative thymocyte	3 studies	34% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	21% ± 6%	Explore
brain	6 studies	34% ± 13%	Explore
lung	5 studies	21% ± 5%	Explore
kidney	3 studies	16% ± 1%	Explore
eye	3 studies	20% ± 4%	Explore
liver	3 studies	31% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3539.91	1445 / 1445	100%	31.61	183 / 183
lung	100%	2974.99	578 / 578	100%	30.95	1155 / 1155
ovary	100%	4343.01	180 / 180	100%	34.03	430 / 430
prostate	100%	3910.42	245 / 245	100%	42.81	502 / 502
stomach	100%	3505.76	359 / 359	100%	34.22	286 / 286
breast	100%	4175.81	459 / 459	100%	34.89	1117 / 1118
pancreas	100%	2840.25	327 / 328	100%	27.55	178 / 178
kidney	100%	4238.58	89 / 89	100%	38.47	898 / 901
intestine	100%	4160.36	966 / 966	100%	37.17	525 / 527
bladder	100%	3799.90	21 / 21	100%	32.97	502 / 504
thymus	100%	4135.89	653 / 653	100%	37.18	602 / 605
liver	100%	3042.22	226 / 226	99%	27.77	403 / 406
brain	99%	2307.30	2614 / 2642	100%	37.21	705 / 705
uterus	100%	4256.06	170 / 170	99%	29.06	454 / 459
adrenal gland	100%	5665.86	258 / 258	99%	33.11	227 / 230
skin	100%	4158.56	1809 / 1809	98%	38.64	461 / 472
adipose	100%	3806.07	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4201.70	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	39.81	29 / 29
spleen	100%	3434.59	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	25.78	45 / 45
ureter	0%	0	0 / 0	100%	11.78	1 / 1
muscle	100%	2779.56	802 / 803	0%	0	0 / 0
heart	97%	3222.68	835 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	26.38	76 / 80
peripheral blood	90%	2543.16	836 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006851	Biological process	mitochondrial calcium ion transmembrane transport
GO_0006627	Biological process	protein processing involved in protein targeting to mitochondrion
GO_0017087	Cellular component	mitochondrial processing peptidase complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0004222	Molecular function	metalloendopeptidase activity
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	PMPCB
Protein name	Peptidase, mitochondrial processing subunit beta Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52) Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) PMPCB protein
Synonyms	MPPB hCG_18192
Description	FUNCTION: Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis . .
Accessions	ENST00000706457.1 A0A9L9PWW3 F8WEC8 A0A9L9PX59 O75439 ENST00000453466.1 G3V0E4 ENST00000706448.1 ENST00000706443.1 ENST00000249269.9 ENST00000706440.1 A0A9L9PXH4 ENST00000706460.1 A0A9L9PXH0 ENST00000443722.5 A0A9L9PX50 ENST00000706442.1 A0A9L9PXH7 F8WBE1 ENST00000706459.1 A0A9L9PX42 ENST00000706452.1 ENST00000706439.1 ENST00000706454.1 A0A9L9PXG6 A0A9L9PWX2 F8WEA6 Q96CP5 A0A9L9PXI7 F8WAZ6 ENST00000428154.5 ENST00000706437.1 A0A9L9PY03 ENST00000444457.5 ENST00000706451.1 ENST00000706449.1 ENST00000706456.1 ENST00000706447.1 ENST00000456433.5 ENST00000706450.1 ENST00000706453.1

PMPCB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review