PLEKHJ1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	22 studies	24% ± 7%	Explore
natural killer cell	14 studies	22% ± 7%	Explore
memory B cell	14 studies	21% ± 4%	Explore
naive B cell	13 studies	18% ± 3%	Explore
CD8-positive, alpha-beta T cell	13 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	11 studies	21% ± 5%	Explore
plasmacytoid dendritic cell	11 studies	26% ± 8%	Explore
regulatory T cell	11 studies	20% ± 2%	Explore
epithelial cell	10 studies	40% ± 19%	Explore
type I pneumocyte	9 studies	29% ± 8%	Explore
fibroblast	9 studies	24% ± 7%	Explore
non-classical monocyte	8 studies	28% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	20% ± 5%	Explore
gamma-delta T cell	8 studies	23% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	21% ± 3%	Explore
progenitor cell	7 studies	33% ± 9%	Explore
enterocyte	7 studies	30% ± 11%	Explore
goblet cell	7 studies	33% ± 14%	Explore
connective tissue cell	6 studies	26% ± 8%	Explore
smooth muscle cell	6 studies	19% ± 2%	Explore
transit amplifying cell	6 studies	28% ± 13%	Explore
mucosal invariant T cell	6 studies	19% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	22% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 2%	Explore
classical monocyte	5 studies	28% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	24% ± 4%	Explore
mature NK T cell	5 studies	21% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
T cell	5 studies	18% ± 1%	Explore
pericyte	5 studies	20% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
abnormal cell	5 studies	23% ± 4%	Explore
plasmablast	4 studies	42% ± 17%	Explore
exhausted T cell	4 studies	27% ± 10%	Explore
kidney loop of Henle epithelial cell	4 studies	20% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	26% ± 7%	Explore
epithelial cell of proximal tubule	4 studies	18% ± 2%	Explore
enteroendocrine cell	4 studies	32% ± 13%	Explore
myofibroblast cell	4 studies	20% ± 5%	Explore
precursor B cell	4 studies	19% ± 1%	Explore
ciliated cell	4 studies	32% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	21% ± 6%	Explore
plasma cell	3 studies	27% ± 15%	Explore
conventional dendritic cell	3 studies	41% ± 16%	Explore
hematopoietic precursor cell	3 studies	31% ± 4%	Explore
renal alpha-intercalated cell	3 studies	31% ± 9%	Explore
intestinal crypt stem cell	3 studies	38% ± 1%	Explore
leukocyte	3 studies	21% ± 7%	Explore
neural crest cell	3 studies	21% ± 1%	Explore
erythroblast	3 studies	34% ± 15%	Explore
monocyte	3 studies	21% ± 3%	Explore
T follicular helper cell	3 studies	19% ± 1%	Explore
neuron	3 studies	26% ± 14%	Explore
glutamatergic neuron	3 studies	27% ± 7%	Explore
dendritic cell	3 studies	45% ± 13%	Explore
brush cell	3 studies	22% ± 2%	Explore
double negative thymocyte	3 studies	26% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	23% ± 8%	Explore
intestine	9 studies	25% ± 11%	Explore
lung	6 studies	27% ± 9%	Explore
kidney	4 studies	16% ± 1%	Explore
lymph node	4 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	2709.32	328 / 328	100%	36.51	178 / 178
thymus	100%	4083.52	653 / 653	100%	36.99	604 / 605
brain	100%	1988.69	2635 / 2642	100%	36.58	705 / 705
stomach	100%	3876.88	359 / 359	100%	46.56	285 / 286
uterus	100%	1938.19	170 / 170	100%	40.23	457 / 459
liver	100%	2142.37	226 / 226	100%	29.56	404 / 406
prostate	100%	2499.04	245 / 245	99%	40.24	498 / 502
kidney	100%	4716.27	89 / 89	99%	29.77	893 / 901
intestine	100%	4428.98	966 / 966	99%	63.27	522 / 527
bladder	100%	2137.52	21 / 21	99%	51.56	499 / 504
skin	100%	2504.81	1809 / 1809	99%	30.54	467 / 472
ovary	100%	2248.32	180 / 180	99%	17.77	425 / 430
breast	100%	2164.78	459 / 459	98%	28.19	1099 / 1118
lung	100%	2386.30	576 / 578	98%	26.87	1137 / 1155
adrenal gland	100%	3145.07	258 / 258	97%	28.60	222 / 230
esophagus	100%	2245.82	1445 / 1445	95%	16.40	174 / 183
adipose	100%	2058.62	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	29.19	80 / 80
lymph node	0%	0	0 / 0	100%	75.64	29 / 29
muscle	100%	2561.39	803 / 803	0%	0	0 / 0
spleen	100%	3371.01	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	34.63	45 / 45
ureter	0%	0	0 / 0	100%	41.47	1 / 1
heart	99%	2202.40	853 / 861	0%	0	0 / 0
blood vessel	99%	1436.77	1321 / 1335	0%	0	0 / 0
peripheral blood	97%	2217.77	903 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0042147	Biological process	retrograde transport, endosome to Golgi
GO_0001881	Biological process	receptor recycling
GO_0007032	Biological process	endosome organization
GO_0005802	Cellular component	trans-Golgi network
GO_0005829	Cellular component	cytosol
GO_0055037	Cellular component	recycling endosome
GO_0005769	Cellular component	early endosome
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PLEKHJ1
Protein name	Pleckstrin homology domain containing J1 Sesquipedalian (Ses) (PH domain-containing endocytic trafficking adaptor) Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x) Pleckstrin homology domain-containing family J member 1
Synonyms	GNRPX
Description	FUNCTION: Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. .
Accessions	ENST00000586608.3 ENST00000589097.6 ENST00000591099.6 ENST00000587394.6 K7EIZ3 Q9NW61 ENST00000326631.7 K7ERH2 ENST00000587962.6 K7ERW3 K7EIW9

PLEKHJ1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review