PDE4B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	32 studies	34% ± 16%	Explore
B cell	31 studies	33% ± 8%	Explore
T cell	19 studies	25% ± 7%	Explore
naive B cell	19 studies	39% ± 12%	Explore
CD8-positive, alpha-beta T cell	18 studies	20% ± 5%	Explore
memory B cell	18 studies	34% ± 13%	Explore
regulatory T cell	18 studies	27% ± 7%	Explore
plasmacytoid dendritic cell	17 studies	29% ± 13%	Explore
astrocyte	17 studies	69% ± 18%	Explore
classical monocyte	16 studies	29% ± 12%	Explore
endothelial cell	16 studies	33% ± 18%	Explore
CD4-positive, alpha-beta T cell	16 studies	26% ± 8%	Explore
oligodendrocyte	15 studies	92% ± 7%	Explore
oligodendrocyte precursor cell	15 studies	89% ± 9%	Explore
microglial cell	15 studies	50% ± 17%	Explore
plasma cell	14 studies	32% ± 9%	Explore
conventional dendritic cell	14 studies	29% ± 9%	Explore
dendritic cell	13 studies	37% ± 10%	Explore
monocyte	13 studies	35% ± 9%	Explore
myeloid cell	13 studies	30% ± 13%	Explore
non-classical monocyte	12 studies	28% ± 10%	Explore
glutamatergic neuron	12 studies	51% ± 18%	Explore
mucosal invariant T cell	12 studies	29% ± 13%	Explore
GABAergic neuron	11 studies	54% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	29% ± 10%	Explore
gamma-delta T cell	9 studies	26% ± 10%	Explore
leukocyte	8 studies	36% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	23% ± 6%	Explore
natural killer cell	8 studies	22% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	25% ± 8%	Explore
endothelial cell of lymphatic vessel	8 studies	31% ± 13%	Explore
neutrophil	7 studies	30% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	31% ± 13%	Explore
mononuclear phagocyte	6 studies	28% ± 12%	Explore
neuron	6 studies	44% ± 17%	Explore
interneuron	6 studies	58% ± 17%	Explore
retina horizontal cell	6 studies	62% ± 28%	Explore
plasmablast	6 studies	29% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	25% ± 7%	Explore
IgG plasma cell	5 studies	22% ± 6%	Explore
lymphocyte	5 studies	32% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	27% ± 11%	Explore
mature NK T cell	5 studies	24% ± 10%	Explore
granule cell	4 studies	53% ± 15%	Explore
pro-B cell	4 studies	30% ± 8%	Explore
capillary endothelial cell	4 studies	27% ± 11%	Explore
amacrine cell	4 studies	25% ± 7%	Explore
mesothelial cell	4 studies	21% ± 5%	Explore
retinal ganglion cell	4 studies	67% ± 22%	Explore
innate lymphoid cell	4 studies	26% ± 10%	Explore
luminal cell of prostate epithelium	4 studies	25% ± 6%	Explore
T follicular helper cell	4 studies	22% ± 3%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	92% ± 3%	Explore
pericyte	3 studies	38% ± 17%	Explore
GABAergic interneuron	3 studies	59% ± 10%	Explore
glial cell	3 studies	55% ± 27%	Explore
immature B cell	3 studies	25% ± 1%	Explore
tissue-resident macrophage	3 studies	39% ± 14%	Explore
retinal bipolar neuron	3 studies	49% ± 24%	Explore
GABAergic amacrine cell	3 studies	29% ± 10%	Explore
OFF-bipolar cell	3 studies	53% ± 13%	Explore
ON-bipolar cell	3 studies	56% ± 14%	Explore
CD4-positive helper T cell	3 studies	36% ± 15%	Explore
IgA plasma cell	3 studies	35% ± 12%	Explore
retinal pigment epithelial cell	3 studies	55% ± 24%	Explore
abnormal cell	3 studies	22% ± 5%	Explore
hematopoietic stem cell	3 studies	27% ± 3%	Explore
alveolar macrophage	3 studies	50% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	60% ± 16%	Explore
lung	8 studies	20% ± 4%	Explore
peripheral blood	5 studies	26% ± 5%	Explore
eye	5 studies	22% ± 3%	Explore
breast	3 studies	19% ± 1%	Explore
lymph node	3 studies	23% ± 7%	Explore
adipose	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4134.78	2641 / 2642	100%	61.00	704 / 705
prostate	98%	2607.89	239 / 245	94%	20.51	474 / 502
breast	95%	3166.45	436 / 459	82%	21.74	919 / 1118
skin	91%	1486.97	1651 / 1809	81%	17.11	384 / 472
lung	100%	2789.38	576 / 578	72%	8.11	826 / 1155
thymus	92%	1456.41	601 / 653	64%	5.87	386 / 605
intestine	77%	1082.10	745 / 966	49%	4.69	258 / 527
kidney	64%	749.94	57 / 89	60%	6.68	544 / 901
bladder	81%	742.52	17 / 21	38%	3.74	192 / 504
esophagus	53%	553.78	760 / 1445	55%	5.85	101 / 183
stomach	44%	472.81	157 / 359	59%	6.58	168 / 286
spleen	100%	3483.78	241 / 241	0%	0	0 / 0
adipose	98%	2546.07	1181 / 1204	0%	0	0 / 0
blood vessel	95%	2092.03	1263 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	20.59	27 / 29
peripheral blood	88%	2209.71	813 / 929	0%	0	0 / 0
uterus	49%	463.55	84 / 170	37%	4.47	170 / 459
muscle	84%	3897.37	676 / 803	0%	0	0 / 0
heart	82%	1906.03	710 / 861	0%	0	0 / 0
adrenal gland	32%	245.87	82 / 258	47%	5.48	107 / 230
tonsil	0%	0	0 / 0	58%	7.59	26 / 45
pancreas	2%	13.31	6 / 328	54%	4.79	96 / 178
ovary	27%	248.71	49 / 180	27%	2.22	118 / 430
liver	30%	234.92	68 / 226	20%	1.77	83 / 406
eye	0%	0	0 / 0	31%	3.63	25 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001780	Biological process	neutrophil homeostasis
GO_1901898	Biological process	negative regulation of relaxation of cardiac muscle
GO_1902514	Biological process	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0086004	Biological process	regulation of cardiac muscle cell contraction
GO_0030593	Biological process	neutrophil chemotaxis
GO_0019933	Biological process	cAMP-mediated signaling
GO_0071872	Biological process	cellular response to epinephrine stimulus
GO_0050852	Biological process	T cell receptor signaling pathway
GO_0032743	Biological process	positive regulation of interleukin-2 production
GO_0050900	Biological process	leukocyte migration
GO_0071878	Biological process	negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0006198	Biological process	cAMP catabolic process
GO_0043197	Cellular component	dendritic spine
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0030018	Cellular component	Z disc
GO_0005813	Cellular component	centrosome
GO_0005891	Cellular component	voltage-gated calcium channel complex
GO_0000930	Cellular component	gamma-tubulin complex
GO_0005829	Cellular component	cytosol
GO_0008021	Cellular component	synaptic vesicle
GO_0014069	Cellular component	postsynaptic density
GO_0060076	Cellular component	excitatory synapse
GO_0005634	Cellular component	nucleus
GO_0043015	Molecular function	gamma-tubulin binding
GO_0030552	Molecular function	cAMP binding
GO_0005246	Molecular function	calcium channel regulator activity
GO_0047555	Molecular function	3',5'-cyclic-GMP phosphodiesterase activity
GO_0046872	Molecular function	metal ion binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0004115	Molecular function	3',5'-cyclic-AMP phosphodiesterase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PDE4B
Protein name	3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) Phosphodiesterase (EC 3.1.4.-) Phosphodiesterase 4B cAMP-specific isoform C 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53)
Synonyms	DPDE4
Description	FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. .
Accessions	X5DPA9 ENST00000329654.8 [Q07343-1] E9PJ03 E9PR34 ENST00000371045.9 [Q07343-2] ENST00000423207.6 [Q07343-3] ENST00000412480.6 ENST00000491340.2 Q07343 X5DR82 E9PMG3 ENST00000341517.9 [Q07343-1] E9PNB0 ENST00000528771.5 H0YCV7 ENST00000480109.2 [Q07343-4] ENST00000531025.5 X5DNX5 ENST00000526197.5

PDE4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review