PBRM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	29 studies	29% ± 13%	Explore
macrophage	24 studies	30% ± 15%	Explore
astrocyte	16 studies	36% ± 17%	Explore
pericyte	16 studies	24% ± 11%	Explore
fibroblast	16 studies	24% ± 7%	Explore
smooth muscle cell	15 studies	22% ± 6%	Explore
ciliated cell	15 studies	31% ± 10%	Explore
oligodendrocyte	14 studies	35% ± 15%	Explore
microglial cell	12 studies	39% ± 14%	Explore
oligodendrocyte precursor cell	11 studies	37% ± 15%	Explore
plasmacytoid dendritic cell	11 studies	23% ± 8%	Explore
natural killer cell	10 studies	21% ± 4%	Explore
GABAergic neuron	10 studies	44% ± 21%	Explore
glutamatergic neuron	10 studies	45% ± 25%	Explore
endothelial cell of lymphatic vessel	9 studies	28% ± 9%	Explore
classical monocyte	9 studies	22% ± 8%	Explore
myeloid cell	9 studies	37% ± 11%	Explore
epithelial cell	9 studies	37% ± 16%	Explore
adipocyte	9 studies	50% ± 8%	Explore
B cell	8 studies	24% ± 5%	Explore
neuron	8 studies	43% ± 20%	Explore
T cell	7 studies	23% ± 6%	Explore
type I pneumocyte	7 studies	29% ± 8%	Explore
basal cell	7 studies	31% ± 12%	Explore
monocyte	7 studies	33% ± 11%	Explore
dendritic cell	7 studies	38% ± 9%	Explore
non-classical monocyte	6 studies	22% ± 7%	Explore
CD4-positive, alpha-beta T cell	6 studies	20% ± 2%	Explore
interneuron	6 studies	51% ± 19%	Explore
club cell	6 studies	30% ± 8%	Explore
retinal cone cell	6 studies	21% ± 3%	Explore
CD8-positive, alpha-beta T cell	6 studies	18% ± 2%	Explore
mast cell	6 studies	27% ± 9%	Explore
type II pneumocyte	6 studies	31% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	17% ± 2%	Explore
conventional dendritic cell	5 studies	26% ± 15%	Explore
connective tissue cell	5 studies	21% ± 6%	Explore
retinal ganglion cell	5 studies	26% ± 5%	Explore
amacrine cell	5 studies	25% ± 3%	Explore
retina horizontal cell	5 studies	25% ± 5%	Explore
cardiac muscle cell	5 studies	31% ± 5%	Explore
respiratory goblet cell	5 studies	28% ± 10%	Explore
goblet cell	5 studies	30% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	19% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	20% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	19% ± 2%	Explore
abnormal cell	4 studies	27% ± 14%	Explore
granule cell	4 studies	29% ± 7%	Explore
precursor B cell	4 studies	27% ± 7%	Explore
myofibroblast cell	4 studies	28% ± 9%	Explore
pro-B cell	4 studies	27% ± 5%	Explore
retinal bipolar neuron	4 studies	22% ± 4%	Explore
retinal pigment epithelial cell	4 studies	31% ± 18%	Explore
mesothelial cell	4 studies	26% ± 9%	Explore
lymphocyte	4 studies	30% ± 7%	Explore
Mueller cell	4 studies	25% ± 3%	Explore
retinal rod cell	4 studies	29% ± 6%	Explore
endothelial cell of vascular tree	4 studies	25% ± 10%	Explore
hepatocyte	4 studies	51% ± 16%	Explore
muscle cell	4 studies	28% ± 13%	Explore
leukocyte	4 studies	30% ± 10%	Explore
alveolar macrophage	4 studies	42% ± 17%	Explore
hematopoietic precursor cell	3 studies	26% ± 6%	Explore
GABAergic interneuron	3 studies	32% ± 9%	Explore
glial cell	3 studies	29% ± 4%	Explore
progenitor cell	3 studies	30% ± 7%	Explore
plasma cell	3 studies	39% ± 7%	Explore
squamous epithelial cell	3 studies	39% ± 22%	Explore
brush cell	3 studies	34% ± 10%	Explore
mononuclear phagocyte	3 studies	35% ± 6%	Explore
vein endothelial cell	3 studies	25% ± 10%	Explore
GABAergic amacrine cell	3 studies	26% ± 3%	Explore
ON-bipolar cell	3 studies	25% ± 7%	Explore
glycinergic amacrine cell	3 studies	27% ± 4%	Explore
rod bipolar cell	3 studies	23% ± 5%	Explore
ependymal cell	3 studies	48% ± 13%	Explore
enteroendocrine cell	3 studies	24% ± 6%	Explore
intestinal crypt stem cell	3 studies	18% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	18% ± 1%	Explore
transit amplifying cell	3 studies	38% ± 22%	Explore
naive B cell	3 studies	16% ± 1%	Explore
mural cell	3 studies	32% ± 10%	Explore
mucus secreting cell	3 studies	25% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	38% ± 19%	Explore
lung	10 studies	27% ± 7%	Explore
eye	6 studies	30% ± 12%	Explore
heart	5 studies	26% ± 6%	Explore
peripheral blood	4 studies	27% ± 9%	Explore
adipose	4 studies	32% ± 12%	Explore
liver	3 studies	42% ± 10%	Explore
bone marrow	3 studies	21% ± 7%	Explore
intestine	3 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3863.78	1445 / 1445	100%	25.76	183 / 183
intestine	100%	3872.94	966 / 966	100%	18.63	526 / 527
prostate	100%	3165.29	245 / 245	100%	24.28	501 / 502
lung	100%	3337.05	578 / 578	100%	19.05	1150 / 1155
bladder	100%	3887.76	21 / 21	99%	20.17	501 / 504
breast	100%	3974.20	459 / 459	99%	30.15	1111 / 1118
thymus	100%	3766.24	653 / 653	99%	23.65	600 / 605
pancreas	100%	1863.05	327 / 328	99%	17.03	177 / 178
uterus	100%	4491.05	170 / 170	99%	20.97	453 / 459
brain	98%	1680.07	2598 / 2642	100%	20.43	705 / 705
stomach	100%	2541.23	359 / 359	98%	21.77	281 / 286
ovary	100%	4719.41	180 / 180	98%	15.68	422 / 430
skin	100%	4265.91	1809 / 1809	98%	29.00	462 / 472
kidney	100%	1715.25	89 / 89	91%	11.24	821 / 901
adrenal gland	100%	2923.94	258 / 258	90%	10.17	207 / 230
liver	100%	1711.02	226 / 226	88%	8.55	357 / 406
adipose	100%	4406.82	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4111.96	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	18.92	29 / 29
spleen	100%	3375.16	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	8.96	1 / 1
muscle	100%	2580.08	802 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	21.17	44 / 45
heart	98%	2161.45	840 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	81%	10.60	65 / 80
peripheral blood	75%	1753.67	695 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0030071	Biological process	regulation of mitotic metaphase/anaphase transition
GO_0000278	Biological process	mitotic cell cycle
GO_0045582	Biological process	positive regulation of T cell differentiation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_0006368	Biological process	transcription elongation by RNA polymerase II
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_0006338	Biological process	chromatin remodeling
GO_0070316	Biological process	regulation of G0 to G1 transition
GO_0045597	Biological process	positive regulation of cell differentiation
GO_2000819	Biological process	regulation of nucleotide-excision repair
GO_2000781	Biological process	positive regulation of double-strand break repair
GO_0000228	Cellular component	nuclear chromosome
GO_0000776	Cellular component	kinetochore
GO_0016514	Cellular component	SWI/SNF complex
GO_0005654	Cellular component	nucleoplasm
GO_0016363	Cellular component	nuclear matrix
GO_0016586	Cellular component	RSC-type complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PBRM1
Protein name	Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D) Polybromo 1
Synonyms	PB1 BAF180
Description	FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation. .
Accessions	ENST00000356770.8 [Q86U86-3] ENST00000394830.7 [Q86U86-4] C9J9L6 ENST00000450271.5 ENST00000409767.5 [Q86U86-7] ENST00000420148.5 ENST00000423351.5 ENST00000412587.5 [Q86U86-6] ENST00000439181.5 A0A9L9PXL4 C9J053 E7EVG2 ENST00000337303.8 [Q86U86-5] ENST00000446103.5 ENST00000409114.7 [Q86U86-8] C9JCJ2 ENST00000431678.5 ENST00000449505.5 ENST00000409057.5 [Q86U86-2] C9JPI5 ENST00000458294.5 Q86U86 ENST00000296302.11 [Q86U86-1] C9JQF1 C9J409 ENST00000424867.1 ENST00000707071.1 H0Y5B5 ENST00000410007.5 [Q86U86-9]

PBRM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review