OGA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	30% ± 11%	Explore
endothelial cell	35 studies	29% ± 13%	Explore
natural killer cell	32 studies	28% ± 10%	Explore
T cell	24 studies	28% ± 10%	Explore
fibroblast	24 studies	27% ± 12%	Explore
CD8-positive, alpha-beta T cell	23 studies	26% ± 9%	Explore
CD4-positive, alpha-beta T cell	20 studies	25% ± 8%	Explore
pericyte	18 studies	25% ± 13%	Explore
macrophage	17 studies	32% ± 18%	Explore
smooth muscle cell	16 studies	25% ± 10%	Explore
astrocyte	16 studies	40% ± 15%	Explore
regulatory T cell	16 studies	27% ± 8%	Explore
naive B cell	15 studies	27% ± 7%	Explore
memory B cell	14 studies	29% ± 7%	Explore
mature NK T cell	14 studies	24% ± 6%	Explore
monocyte	13 studies	30% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	31% ± 8%	Explore
ciliated cell	12 studies	30% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	25% ± 8%	Explore
glutamatergic neuron	12 studies	52% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	31% ± 8%	Explore
gamma-delta T cell	12 studies	28% ± 10%	Explore
epithelial cell	12 studies	37% ± 20%	Explore
mast cell	11 studies	26% ± 11%	Explore
classical monocyte	11 studies	24% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	23% ± 7%	Explore
GABAergic neuron	11 studies	49% ± 21%	Explore
oligodendrocyte precursor cell	11 studies	35% ± 14%	Explore
mucosal invariant T cell	11 studies	26% ± 7%	Explore
microglial cell	11 studies	33% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	28% ± 7%	Explore
capillary endothelial cell	10 studies	21% ± 6%	Explore
adipocyte	10 studies	63% ± 19%	Explore
oligodendrocyte	10 studies	30% ± 10%	Explore
type I pneumocyte	9 studies	36% ± 12%	Explore
myeloid cell	9 studies	25% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	25% ± 6%	Explore
basal cell	8 studies	35% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	31% ± 9%	Explore
amacrine cell	8 studies	39% ± 11%	Explore
plasmacytoid dendritic cell	8 studies	24% ± 8%	Explore
dendritic cell	8 studies	37% ± 19%	Explore
endothelial cell of lymphatic vessel	7 studies	29% ± 12%	Explore
leukocyte	7 studies	34% ± 16%	Explore
non-classical monocyte	7 studies	27% ± 15%	Explore
abnormal cell	7 studies	25% ± 8%	Explore
neuron	7 studies	39% ± 15%	Explore
retinal ganglion cell	7 studies	49% ± 20%	Explore
retinal cone cell	7 studies	49% ± 11%	Explore
retinal rod cell	7 studies	31% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
endothelial cell of artery	6 studies	20% ± 3%	Explore
myofibroblast cell	6 studies	28% ± 13%	Explore
type II pneumocyte	6 studies	28% ± 8%	Explore
retina horizontal cell	6 studies	42% ± 10%	Explore
vein endothelial cell	6 studies	28% ± 19%	Explore
Mueller cell	6 studies	30% ± 11%	Explore
endothelial cell of vascular tree	6 studies	28% ± 16%	Explore
goblet cell	6 studies	33% ± 23%	Explore
retinal bipolar neuron	5 studies	41% ± 7%	Explore
precursor B cell	5 studies	34% ± 9%	Explore
pro-B cell	5 studies	26% ± 2%	Explore
club cell	5 studies	30% ± 11%	Explore
immature B cell	5 studies	34% ± 10%	Explore
cardiac muscle cell	5 studies	33% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 13%	Explore
connective tissue cell	5 studies	24% ± 4%	Explore
T follicular helper cell	5 studies	22% ± 4%	Explore
interneuron	5 studies	64% ± 12%	Explore
secretory cell	4 studies	25% ± 5%	Explore
plasmablast	4 studies	34% ± 13%	Explore
exhausted T cell	4 studies	29% ± 14%	Explore
epithelial cell of proximal tubule	4 studies	23% ± 4%	Explore
plasma cell	4 studies	33% ± 11%	Explore
retinal pigment epithelial cell	4 studies	37% ± 20%	Explore
mesothelial cell	4 studies	29% ± 10%	Explore
OFF-bipolar cell	4 studies	37% ± 14%	Explore
ON-bipolar cell	4 studies	41% ± 14%	Explore
innate lymphoid cell	4 studies	24% ± 2%	Explore
brush cell	4 studies	25% ± 6%	Explore
enteroendocrine cell	4 studies	24% ± 7%	Explore
ionocyte	3 studies	22% ± 5%	Explore
conventional dendritic cell	3 studies	49% ± 17%	Explore
glomerular endothelial cell	3 studies	24% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	22% ± 5%	Explore
neural crest cell	3 studies	19% ± 2%	Explore
squamous epithelial cell	3 studies	48% ± 16%	Explore
progenitor cell	3 studies	27% ± 11%	Explore
glial cell	3 studies	27% ± 10%	Explore
mononuclear phagocyte	3 studies	25% ± 7%	Explore
lymphocyte	3 studies	50% ± 15%	Explore
GABAergic amacrine cell	3 studies	42% ± 13%	Explore
glycinergic amacrine cell	3 studies	39% ± 6%	Explore
rod bipolar cell	3 studies	49% ± 11%	Explore
respiratory goblet cell	3 studies	37% ± 10%	Explore
ependymal cell	3 studies	47% ± 18%	Explore
neutrophil	3 studies	25% ± 5%	Explore
alveolar macrophage	3 studies	38% ± 10%	Explore
group 3 innate lymphoid cell	3 studies	36% ± 8%	Explore
Schwann cell	3 studies	34% ± 16%	Explore
melanocyte	3 studies	39% ± 15%	Explore
transit amplifying cell	3 studies	39% ± 30%	Explore
granule cell	3 studies	46% ± 9%	Explore
hepatocyte	3 studies	43% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	42% ± 20%	Explore
peripheral blood	13 studies	27% ± 10%	Explore
lung	12 studies	27% ± 9%	Explore
eye	10 studies	35% ± 15%	Explore
kidney	7 studies	22% ± 6%	Explore
intestine	6 studies	21% ± 7%	Explore
heart	5 studies	28% ± 6%	Explore
bone marrow	4 studies	22% ± 4%	Explore
liver	4 studies	30% ± 12%	Explore
adipose	4 studies	39% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	14776.53	1445 / 1445	100%	60.14	183 / 183
lung	100%	15519.67	578 / 578	100%	58.62	1155 / 1155
prostate	100%	15080.21	245 / 245	100%	79.82	502 / 502
uterus	100%	16858.64	170 / 170	100%	62.83	459 / 459
brain	100%	15744.31	2641 / 2642	100%	93.10	705 / 705
breast	100%	17513.50	459 / 459	100%	102.65	1117 / 1118
thymus	100%	15348.82	653 / 653	100%	92.12	604 / 605
bladder	100%	15735.62	21 / 21	100%	57.15	503 / 504
kidney	100%	11189.10	89 / 89	100%	86.19	898 / 901
adrenal gland	100%	8735.51	258 / 258	99%	57.70	227 / 230
intestine	100%	16313.57	966 / 966	99%	52.14	520 / 527
pancreas	99%	6508.20	325 / 328	99%	63.31	177 / 178
liver	100%	6501.91	226 / 226	98%	35.18	398 / 406
stomach	100%	10087.57	359 / 359	98%	49.83	280 / 286
skin	100%	17570.12	1809 / 1809	96%	52.08	454 / 472
ovary	100%	17507.39	180 / 180	96%	38.14	411 / 430
blood vessel	100%	17748.87	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	75.09	29 / 29
spleen	100%	20470.04	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	64.72	45 / 45
ureter	0%	0	0 / 0	100%	33.58	1 / 1
adipose	100%	17209.57	1203 / 1204	0%	0	0 / 0
muscle	100%	8645.59	800 / 803	0%	0	0 / 0
heart	99%	9842.27	852 / 861	0%	0	0 / 0
peripheral blood	97%	13214.69	902 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	89%	42.94	71 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006517	Biological process	protein deglycosylation
GO_0006044	Biological process	N-acetylglucosamine metabolic process
GO_0009100	Biological process	glycoprotein metabolic process
GO_0006493	Biological process	protein O-linked glycosylation
GO_0006516	Biological process	glycoprotein catabolic process
GO_0005829	Cellular component	cytosol
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0016231	Molecular function	beta-N-acetylglucosaminidase activity
GO_0102571	Molecular function	[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
GO_0004415	Molecular function	hyalurononglucosaminidase activity
GO_0042802	Molecular function	identical protein binding

IV. Literature review

[source]

Gene name	OGA
Protein name	O-GlcNAcase Protein O-GlcNAcase (OGA) (EC 3.2.1.169) (Beta-N-acetylglucosaminidase) (Beta-N-acetylhexosaminidase) (Beta-hexosaminidase) (Meningioma-expressed antigen 5) (N-acetyl-beta-D-glucosaminidase) (N-acetyl-beta-glucosaminidase) (Nuclear cytoplasmic O-GlcNAcase and acetyltransferase) (NCOAT)
Synonyms	MGEA5 KIAA0679 HEXC MEA5
Description	FUNCTION: [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins . Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, LMNB1 and TAB1 . Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) . Does not bind acetyl-CoA and does not have histone acetyltransferase activity . .; FUNCTION: [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. .
Accessions	ENST00000439817.5 [O60502-4] ENST00000357797.9 [O60502-2] ENST00000361464.8 [O60502-1] ENST00000370094.7 [O60502-3] O60502 H7C3X0 ENST00000429860.1

OGA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review