NUMA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0051301Biological processcell division
GO_1905832Biological processpositive regulation of spindle assembly
GO_1902846Biological processpositive regulation of mitotic spindle elongation
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0051798Biological processpositive regulation of hair follicle development
GO_1902365Biological processpositive regulation of protein localization to spindle pole body
GO_0006997Biological processnucleus organization
GO_0051321Biological processmeiotic cell cycle
GO_0030513Biological processpositive regulation of BMP signaling pathway
GO_0051984Biological processpositive regulation of chromosome segregation
GO_1905820Biological processpositive regulation of chromosome separation
GO_0030953Biological processastral microtubule organization
GO_0032388Biological processpositive regulation of intracellular transport
GO_0060236Biological processregulation of mitotic spindle organization
GO_1904778Biological processpositive regulation of protein localization to cell cortex
GO_0090235Biological processregulation of metaphase plate congression
GO_0055048Biological processanastral spindle assembly
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0001578Biological processmicrotubule bundle formation
GO_0097431Cellular componentmitotic spindle pole
GO_0005876Cellular componentspindle microtubule
GO_0099738Cellular componentcell cortex region
GO_0005886Cellular componentplasma membrane
GO_0000922Cellular componentspindle pole
GO_0072686Cellular componentmitotic spindle
GO_0031616Cellular componentspindle pole centrosome
GO_0005813Cellular componentcentrosome
GO_0035371Cellular componentmicrotubule plus-end
GO_0036449Cellular componentmicrotubule minus-end
GO_0097575Cellular componentlateral cell cortex
GO_0032991Cellular componentprotein-containing complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0097427Cellular componentmicrotubule bundle
GO_1905720Cellular componentcytoplasmic microtubule bundle
GO_0030425Cellular componentdendrite
GO_1990023Cellular componentmitotic spindle midzone
GO_0016363Cellular componentnuclear matrix
GO_0061673Cellular componentmitotic spindle astral microtubule
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0016328Cellular componentlateral plasma membrane
GO_0055028Cellular componentcortical microtubule
GO_0005694Cellular componentchromosome
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0019904Molecular functionprotein domain specific binding
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0051011Molecular functionmicrotubule minus-end binding
GO_0015631Molecular functiontubulin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0005198Molecular functionstructural molecule activity
GO_0008017Molecular functionmicrotubule binding
GO_0070840Molecular functiondynein complex binding
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNUMA1
Protein nameNuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Nuclear mitotic apparatus protein 1
NUMA1 protein
NUMA1 variant protein
SynonymsNMP22
NUMA
protein
variant
DescriptionFUNCTION: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division . Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles . Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner . In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle . During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation . Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro . Also required for proper orientation of the mitotic spindle during asymmetric cell divisions . Plays a role in mitotic MT aster assembly . Involved in anastral spindle assembly . Positively regulates TNKS protein localization to spindle poles in mitosis . Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume . Required for epidermal differentiation and hair follicle morphogenesis (By similarity). .

AccessionsF5H6Y5
Q9UNL7
ENST00000537930.5
ENST00000351960.10 [Q14980-5]
ENST00000535838.5
F5H2F3
Q3SYK8
F5H4Y4
ENST00000541584.5
ENST00000358965.10 [Q14980-2]
ENST00000535111.5
ENST00000535947.5
ENST00000613205.4 [Q14980-5]
ENST00000366394.7
F5H0Z7
G1UI36
ENST00000544129.5
ENST00000620566.4 [Q14980-2]
H0YFY6
F5H068
K4DIE0
ENST00000544238.5
ENST00000535087.5
F5H7R5
F5H763
F8W6T3
F5H1L0
ENST00000537217.5
F5GZW1
F5H073
Q4LE64
ENST00000542977.5
ENST00000543009.5
F5GWA2
ENST00000368959.9
ENST00000393695.8 [Q14980-1]
ENST00000546131.1
ENST00000541641.5
ENST00000545721.1
Q14980
F5H4J1
F5GWK2
ENST00000543937.5
F5H3L6
ENST00000541719.5