NT5C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	28 studies	26% ± 9%	Explore
natural killer cell	28 studies	25% ± 7%	Explore
memory B cell	19 studies	28% ± 8%	Explore
naive B cell	17 studies	27% ± 7%	Explore
fibroblast	15 studies	23% ± 8%	Explore
regulatory T cell	15 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	14 studies	26% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	28% ± 8%	Explore
gamma-delta T cell	13 studies	22% ± 10%	Explore
basal cell	12 studies	29% ± 11%	Explore
pericyte	12 studies	24% ± 6%	Explore
smooth muscle cell	12 studies	21% ± 6%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	29% ± 6%	Explore
non-classical monocyte	11 studies	24% ± 12%	Explore
macrophage	11 studies	20% ± 7%	Explore
epithelial cell	11 studies	34% ± 17%	Explore
conventional dendritic cell	9 studies	26% ± 13%	Explore
T cell	8 studies	19% ± 3%	Explore
CD4-positive, alpha-beta T cell	8 studies	23% ± 5%	Explore
mature NK T cell	8 studies	26% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	22% ± 7%	Explore
ciliated cell	8 studies	31% ± 11%	Explore
plasmacytoid dendritic cell	8 studies	26% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	24% ± 9%	Explore
myofibroblast cell	6 studies	23% ± 3%	Explore
progenitor cell	6 studies	20% ± 5%	Explore
connective tissue cell	6 studies	24% ± 7%	Explore
type I pneumocyte	6 studies	23% ± 7%	Explore
abnormal cell	6 studies	25% ± 7%	Explore
mast cell	5 studies	22% ± 11%	Explore
plasmablast	5 studies	42% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	24% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	24% ± 8%	Explore
enterocyte	5 studies	23% ± 5%	Explore
endothelial cell	5 studies	24% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	23% ± 5%	Explore
hematopoietic precursor cell	4 studies	33% ± 14%	Explore
plasma cell	4 studies	26% ± 12%	Explore
classical monocyte	4 studies	24% ± 9%	Explore
exhausted T cell	4 studies	32% ± 8%	Explore
goblet cell	4 studies	26% ± 9%	Explore
immature B cell	4 studies	34% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	16% ± 1%	Explore
secretory cell	3 studies	27% ± 13%	Explore
epithelial cell of proximal tubule	3 studies	20% ± 3%	Explore
retinal bipolar neuron	3 studies	29% ± 9%	Explore
erythroblast	3 studies	29% ± 8%	Explore
hematopoietic stem cell	3 studies	22% ± 6%	Explore
myeloid cell	3 studies	23% ± 9%	Explore
precursor B cell	3 studies	33% ± 8%	Explore
astrocyte	3 studies	23% ± 6%	Explore
monocyte	3 studies	20% ± 3%	Explore
T follicular helper cell	3 studies	18% ± 2%	Explore
germinal center B cell	3 studies	20% ± 3%	Explore
innate lymphoid cell	3 studies	25% ± 5%	Explore
mesothelial cell	3 studies	28% ± 15%	Explore
neuron	3 studies	25% ± 11%	Explore
microglial cell	3 studies	21% ± 3%	Explore
oligodendrocyte precursor cell	3 studies	17% ± 1%	Explore
dendritic cell	3 studies	41% ± 12%	Explore
brush cell	3 studies	38% ± 11%	Explore
leukocyte	3 studies	24% ± 3%	Explore
transit amplifying cell	3 studies	23% ± 8%	Explore
mucosal invariant T cell	3 studies	17% ± 0%	Explore
double negative thymocyte	3 studies	26% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	23% ± 8%	Explore
lung	7 studies	26% ± 10%	Explore
intestine	7 studies	22% ± 9%	Explore
lymph node	4 studies	21% ± 5%	Explore
brain	4 studies	20% ± 2%	Explore
liver	4 studies	23% ± 10%	Explore
eye	3 studies	22% ± 5%	Explore
kidney	3 studies	20% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1055.33	1445 / 1445	100%	28.63	183 / 183
uterus	100%	1148.46	170 / 170	100%	42.28	459 / 459
thymus	100%	1344.82	653 / 653	100%	41.20	604 / 605
ovary	100%	1297.87	180 / 180	100%	26.87	429 / 430
intestine	100%	1321.17	966 / 966	100%	42.45	525 / 527
skin	100%	919.93	1809 / 1809	99%	30.33	469 / 472
kidney	100%	1146.08	89 / 89	99%	34.26	893 / 901
stomach	100%	900.81	359 / 359	99%	32.75	283 / 286
brain	99%	599.79	2618 / 2642	100%	27.45	704 / 705
bladder	100%	1234.67	21 / 21	99%	46.90	497 / 504
pancreas	100%	589.08	327 / 328	99%	38.21	176 / 178
lung	100%	1016.49	577 / 578	98%	29.87	1132 / 1155
liver	100%	508.82	225 / 226	98%	23.61	399 / 406
prostate	100%	1369.31	245 / 245	98%	25.80	490 / 502
breast	100%	983.54	459 / 459	96%	23.32	1072 / 1118
adrenal gland	100%	903.88	258 / 258	93%	17.90	215 / 230
adipose	100%	902.81	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	44.73	80 / 80
lymph node	0%	0	0 / 0	100%	61.25	29 / 29
spleen	100%	1604.07	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.96	45 / 45
ureter	0%	0	0 / 0	100%	67.88	1 / 1
blood vessel	100%	850.34	1333 / 1335	0%	0	0 / 0
muscle	99%	606.62	796 / 803	0%	0	0 / 0
heart	98%	591.59	845 / 861	0%	0	0 / 0
peripheral blood	97%	705.76	899 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006204	Biological process	IMP catabolic process
GO_0006249	Biological process	dCMP catabolic process
GO_0000255	Biological process	allantoin metabolic process
GO_0009223	Biological process	pyrimidine deoxyribonucleotide catabolic process
GO_0046074	Biological process	dTMP catabolic process
GO_0046050	Biological process	UMP catabolic process
GO_0043605	Biological process	amide catabolic process
GO_0046079	Biological process	dUMP catabolic process
GO_0016311	Biological process	dephosphorylation
GO_0046055	Biological process	dGMP catabolic process
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0019103	Molecular function	pyrimidine nucleotide binding
GO_0042802	Molecular function	identical protein binding
GO_0050483	Molecular function	IMP 5'-nucleotidase activity
GO_0046872	Molecular function	metal ion binding
GO_0008252	Molecular function	nucleotidase activity
GO_0008253	Molecular function	5'-nucleotidase activity

IV. Literature review

[source]

Gene name	NT5C
Protein name	5', 3'-nucleotidase, cytosolic 5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)
Synonyms	DNT1 UMPH2
Description	FUNCTION: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Accessions	J3KRC4 ENST00000578407.5 ENST00000580423.5 J3KSX6 ENST00000580758.5 [Q8TCD5-2] ENST00000578337.1 Q8TCD5 ENST00000582744.5 J3KSF0 ENST00000245552.7 [Q8TCD5-1] J3KSY6 ENST00000582160.5 ENST00000582170.1 J3QQX8

NT5C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review