NDUFS3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	18 studies	22% ± 7%	Explore
endothelial cell	14 studies	26% ± 11%	Explore
fibroblast	14 studies	24% ± 10%	Explore
macrophage	13 studies	24% ± 10%	Explore
ciliated cell	12 studies	32% ± 13%	Explore
CD8-positive, alpha-beta T cell	12 studies	27% ± 7%	Explore
pericyte	12 studies	22% ± 5%	Explore
conventional dendritic cell	11 studies	31% ± 15%	Explore
regulatory T cell	11 studies	23% ± 5%	Explore
plasmacytoid dendritic cell	11 studies	28% ± 9%	Explore
basal cell	10 studies	30% ± 16%	Explore
B cell	10 studies	20% ± 7%	Explore
classical monocyte	10 studies	26% ± 10%	Explore
epithelial cell	10 studies	38% ± 19%	Explore
smooth muscle cell	10 studies	25% ± 5%	Explore
non-classical monocyte	9 studies	27% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	20% ± 3%	Explore
progenitor cell	9 studies	28% ± 12%	Explore
plasma cell	8 studies	31% ± 11%	Explore
T cell	8 studies	21% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	19% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	21% ± 4%	Explore
CD4-positive, alpha-beta T cell	8 studies	29% ± 7%	Explore
connective tissue cell	8 studies	27% ± 9%	Explore
monocyte	8 studies	24% ± 8%	Explore
myofibroblast cell	7 studies	24% ± 4%	Explore
memory B cell	7 studies	18% ± 5%	Explore
gamma-delta T cell	7 studies	25% ± 20%	Explore
plasmablast	6 studies	44% ± 23%	Explore
mature NK T cell	6 studies	18% ± 3%	Explore
epithelial cell of proximal tubule	6 studies	29% ± 5%	Explore
neuron	6 studies	31% ± 14%	Explore
enterocyte	6 studies	24% ± 5%	Explore
transit amplifying cell	6 studies	22% ± 5%	Explore
abnormal cell	6 studies	31% ± 14%	Explore
dendritic cell	6 studies	37% ± 19%	Explore
endothelial cell of lymphatic vessel	6 studies	27% ± 8%	Explore
goblet cell	6 studies	24% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	24% ± 9%	Explore
kidney loop of Henle epithelial cell	5 studies	36% ± 13%	Explore
renal alpha-intercalated cell	5 studies	36% ± 6%	Explore
club cell	5 studies	22% ± 6%	Explore
hematopoietic precursor cell	4 studies	41% ± 17%	Explore
secretory cell	4 studies	30% ± 14%	Explore
leukocyte	4 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	21% ± 2%	Explore
exhausted T cell	4 studies	27% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	37% ± 3%	Explore
capillary endothelial cell	4 studies	21% ± 6%	Explore
intestinal crypt stem cell	4 studies	24% ± 11%	Explore
retinal ganglion cell	4 studies	49% ± 27%	Explore
erythroblast	4 studies	37% ± 20%	Explore
pro-B cell	4 studies	28% ± 4%	Explore
precursor B cell	4 studies	29% ± 11%	Explore
astrocyte	4 studies	24% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	23% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	29% ± 7%	Explore
glutamatergic neuron	4 studies	26% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	23% ± 6%	Explore
oligodendrocyte precursor cell	4 studies	24% ± 6%	Explore
enteroendocrine cell	4 studies	32% ± 15%	Explore
pancreatic A cell	3 studies	36% ± 3%	Explore
type B pancreatic cell	3 studies	32% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	18% ± 1%	Explore
neural crest cell	3 studies	25% ± 3%	Explore
vein endothelial cell	3 studies	19% ± 4%	Explore
common myeloid progenitor	3 studies	31% ± 17%	Explore
myeloid cell	3 studies	25% ± 10%	Explore
type I pneumocyte	3 studies	28% ± 6%	Explore
type II pneumocyte	3 studies	26% ± 11%	Explore
amacrine cell	3 studies	34% ± 12%	Explore
retina horizontal cell	3 studies	28% ± 15%	Explore
retinal cone cell	3 studies	42% ± 12%	Explore
serous secreting cell	3 studies	26% ± 4%	Explore
Mueller cell	3 studies	22% ± 4%	Explore
T follicular helper cell	3 studies	17% ± 1%	Explore
endothelial cell of vascular tree	3 studies	18% ± 1%	Explore
intermediate monocyte	3 studies	29% ± 15%	Explore
GABAergic neuron	3 studies	22% ± 3%	Explore
double negative thymocyte	3 studies	34% ± 23%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	23% ± 8%	Explore
intestine	9 studies	23% ± 9%	Explore
lung	9 studies	28% ± 11%	Explore
kidney	7 studies	23% ± 3%	Explore
brain	5 studies	22% ± 4%	Explore
eye	4 studies	26% ± 11%	Explore
pancreas	3 studies	34% ± 3%	Explore
liver	3 studies	35% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	4127.74	258 / 258	100%	48.14	230 / 230
esophagus	100%	2861.21	1445 / 1445	100%	32.56	183 / 183
liver	100%	2525.88	226 / 226	100%	47.78	406 / 406
ovary	100%	1763.05	180 / 180	100%	55.96	430 / 430
skin	100%	2876.71	1809 / 1809	100%	62.46	472 / 472
uterus	100%	2134.41	170 / 170	100%	58.11	459 / 459
brain	100%	4668.94	2641 / 2642	100%	70.50	705 / 705
kidney	100%	3825.80	89 / 89	100%	46.67	900 / 901
thymus	100%	2613.01	652 / 653	100%	50.72	605 / 605
intestine	100%	3802.25	966 / 966	100%	58.19	526 / 527
pancreas	100%	1582.90	327 / 328	100%	40.47	178 / 178
stomach	100%	2965.39	359 / 359	100%	48.21	285 / 286
prostate	100%	2296.00	245 / 245	100%	46.23	500 / 502
bladder	100%	2351.00	21 / 21	99%	51.71	501 / 504
breast	100%	2441.52	459 / 459	99%	49.83	1110 / 1118
lung	99%	2081.11	571 / 578	100%	44.23	1153 / 1155
adipose	100%	2422.51	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	73.61	80 / 80
lymph node	0%	0	0 / 0	100%	76.97	29 / 29
muscle	100%	6837.59	803 / 803	0%	0	0 / 0
spleen	100%	2868.17	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.80	45 / 45
ureter	0%	0	0 / 0	100%	18.61	1 / 1
blood vessel	100%	2096.10	1329 / 1335	0%	0	0 / 0
heart	98%	4903.79	846 / 861	0%	0	0 / 0
peripheral blood	83%	1690.31	772 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006120	Biological process	mitochondrial electron transport, NADH to ubiquinone
GO_0055085	Biological process	transmembrane transport
GO_0042776	Biological process	proton motive force-driven mitochondrial ATP synthesis
GO_0072593	Biological process	reactive oxygen species metabolic process
GO_0021762	Biological process	substantia nigra development
GO_0032981	Biological process	mitochondrial respiratory chain complex I assembly
GO_2001243	Biological process	negative regulation of intrinsic apoptotic signaling pathway
GO_0009060	Biological process	aerobic respiration
GO_0030308	Biological process	negative regulation of cell growth
GO_0005739	Cellular component	mitochondrion
GO_0031966	Cellular component	mitochondrial membrane
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0016604	Cellular component	nuclear body
GO_0005759	Cellular component	mitochondrial matrix
GO_0045271	Cellular component	respiratory chain complex I
GO_0009055	Molecular function	electron transfer activity
GO_0003954	Molecular function	NADH dehydrogenase activity
GO_0008137	Molecular function	NADH dehydrogenase (ubiquinone) activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NDUFS3
Protein name	NADH:ubiquinone oxidoreductase core subunit S3 NADH dehydrogenase (Ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase), isoform CRA_c (NADH:ubiquinone oxidoreductase core subunit S3) NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (Complex I-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit) NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 7.1.1.2) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)
Synonyms	hCG_25184
Description	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I . .
Accessions	E9PS48 ENST00000263774.9 [O75489-1] G3V194 O75489 ENST00000528192.5 ENST00000530295.5 ENST00000529276.1 E9PJE7 E9PKL8 ENST00000534208.5

NDUFS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review