NCOA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035357Biological processperoxisome proliferator activated receptor signaling pathway
GO_0044849Biological processestrous cycle
GO_1904179Biological processpositive regulation of adipose tissue development
GO_0032355Biological processresponse to estradiol
GO_0021766Biological processhippocampus development
GO_0045925Biological processpositive regulation of female receptivity
GO_0060179Biological processmale mating behavior
GO_1904017Biological processcellular response to Thyroglobulin triiodothyronine
GO_0032870Biological processcellular response to hormone stimulus
GO_0060713Biological processlabyrinthine layer morphogenesis
GO_0000435Biological processpositive regulation of transcription from RNA polymerase II promoter by galactose
GO_0006338Biological processchromatin remodeling
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0021549Biological processcerebellum development
GO_0008584Biological processmale gonad development
GO_0032526Biological processresponse to retinoic acid
GO_0021987Biological processcerebral cortex development
GO_0007595Biological processlactation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_1900076Biological processregulation of cellular response to insulin stimulus
GO_0043065Biological processpositive regulation of apoptotic process
GO_0021854Biological processhypothalamus development
GO_0032570Biological processresponse to progesterone
GO_0002155Biological processregulation of thyroid hormone receptor signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0016922Molecular functionnuclear receptor binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0046965Molecular functionnuclear retinoid X receptor binding
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0046983Molecular functionprotein dimerization activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNCOA1
Protein nameNuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Nuclear receptor coactivator 1
SynonymsBHLHE74
SRC1
DescriptionFUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. .

AccessionsENST00000348332.8 [Q15788-1]
ENST00000406961.5 [Q15788-1]
ENST00000405141.5 [Q15788-2]
ENST00000288599.9 [Q15788-2]
B5MCN7
ENST00000395856.3 [Q15788-3]
ENST00000407230.5
Q15788