MBD4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	32 studies	29% ± 9%	Explore
memory B cell	20 studies	30% ± 7%	Explore
naive B cell	19 studies	26% ± 5%	Explore
natural killer cell	13 studies	19% ± 4%	Explore
classical monocyte	10 studies	23% ± 9%	Explore
plasmacytoid dendritic cell	9 studies	20% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	20% ± 4%	Explore
plasma cell	7 studies	25% ± 10%	Explore
CD8-positive, alpha-beta T cell	7 studies	21% ± 6%	Explore
gamma-delta T cell	7 studies	23% ± 10%	Explore
macrophage	7 studies	20% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
endothelial cell	6 studies	20% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	6 studies	20% ± 2%	Explore
microglial cell	6 studies	22% ± 2%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	19% ± 4%	Explore
CD4-positive, alpha-beta T cell	5 studies	22% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 6%	Explore
hematopoietic precursor cell	5 studies	22% ± 6%	Explore
mucosal invariant T cell	5 studies	19% ± 1%	Explore
epithelial cell	5 studies	32% ± 14%	Explore
regulatory T cell	5 studies	18% ± 2%	Explore
deuterosomal cell	4 studies	18% ± 1%	Explore
mature NK T cell	4 studies	19% ± 3%	Explore
precursor B cell	4 studies	21% ± 3%	Explore
immature B cell	4 studies	23% ± 4%	Explore
ciliated cell	4 studies	26% ± 10%	Explore
germinal center B cell	4 studies	39% ± 14%	Explore
T cell	3 studies	20% ± 2%	Explore
mast cell	3 studies	19% ± 2%	Explore
leukocyte	3 studies	25% ± 4%	Explore
conventional dendritic cell	3 studies	31% ± 12%	Explore
non-classical monocyte	3 studies	25% ± 8%	Explore
plasmablast	3 studies	38% ± 12%	Explore
myeloid cell	3 studies	28% ± 6%	Explore
fibroblast	3 studies	22% ± 5%	Explore
abnormal cell	3 studies	24% ± 7%	Explore
glutamatergic neuron	3 studies	31% ± 11%	Explore
monocyte	3 studies	21% ± 7%	Explore
T follicular helper cell	3 studies	18% ± 2%	Explore
basal cell	3 studies	23% ± 1%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	19% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	22% ± 8%	Explore
brain	6 studies	22% ± 7%	Explore
lung	3 studies	22% ± 3%	Explore
eye	3 studies	16% ± 0%	Explore
liver	3 studies	24% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1797.16	1445 / 1445	100%	36.85	183 / 183
lung	100%	2833.12	578 / 578	100%	45.51	1155 / 1155
ovary	100%	3433.32	180 / 180	100%	39.74	430 / 430
pancreas	100%	1504.69	328 / 328	100%	38.89	178 / 178
uterus	100%	2581.16	170 / 170	100%	54.97	459 / 459
breast	100%	2431.28	459 / 459	100%	52.71	1117 / 1118
prostate	100%	2237.43	245 / 245	100%	31.53	501 / 502
brain	100%	1653.97	2636 / 2642	100%	30.20	705 / 705
liver	100%	2030.61	226 / 226	100%	25.81	405 / 406
thymus	100%	2389.08	653 / 653	100%	42.18	603 / 605
kidney	100%	2464.46	89 / 89	99%	32.91	895 / 901
bladder	100%	2016.62	21 / 21	99%	35.43	500 / 504
stomach	100%	1896.82	359 / 359	99%	29.98	282 / 286
intestine	100%	2371.85	966 / 966	98%	30.01	518 / 527
adrenal gland	100%	1921.64	258 / 258	98%	23.35	225 / 230
skin	100%	2029.95	1809 / 1809	96%	30.71	452 / 472
adipose	100%	2198.64	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	89.82	29 / 29
spleen	100%	3939.69	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	61.24	45 / 45
ureter	0%	0	0 / 0	100%	11.71	1 / 1
blood vessel	100%	2247.61	1334 / 1335	0%	0	0 / 0
muscle	100%	1511.03	802 / 803	0%	0	0 / 0
heart	99%	1787.46	850 / 861	0%	0	0 / 0
peripheral blood	97%	2646.79	904 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	63%	8.44	50 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032355	Biological process	response to estradiol
GO_0006281	Biological process	DNA repair
GO_0045008	Biological process	depyrimidination
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0003696	Molecular function	satellite DNA binding
GO_0008263	Molecular function	pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO_0019104	Molecular function	DNA N-glycosylase activity
GO_0005515	Molecular function	protein binding
GO_0004520	Molecular function	DNA endonuclease activity

IV. Literature review

[source]

Gene name	MBD4
Protein name	Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase) Methyl-CpG binding domain 4, DNA glycosylase
Synonyms	MED1
Description	FUNCTION: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. .
Accessions	O95243 ENST00000509828.1 D6RBI7 ENST00000507208.1 [O95243-5] ENST00000249910.5 [O95243-1] ENST00000429544.7 [O95243-2] ENST00000503197.5 [O95243-3] ENST00000393278.6 [O95243-6]

MBD4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review