MAT2A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	29 studies	30% ± 13%	Explore
pericyte	26 studies	32% ± 14%	Explore
smooth muscle cell	26 studies	30% ± 14%	Explore
conventional dendritic cell	24 studies	31% ± 15%	Explore
endothelial cell	22 studies	27% ± 10%	Explore
fibroblast	21 studies	32% ± 14%	Explore
basal cell	16 studies	31% ± 16%	Explore
classical monocyte	16 studies	29% ± 9%	Explore
B cell	15 studies	21% ± 4%	Explore
mast cell	15 studies	25% ± 7%	Explore
astrocyte	14 studies	32% ± 16%	Explore
natural killer cell	13 studies	22% ± 5%	Explore
dendritic cell	12 studies	34% ± 15%	Explore
oligodendrocyte	12 studies	27% ± 12%	Explore
monocyte	11 studies	29% ± 13%	Explore
regulatory T cell	11 studies	20% ± 4%	Explore
epithelial cell	10 studies	31% ± 17%	Explore
T cell	9 studies	24% ± 9%	Explore
CD8-positive, alpha-beta T cell	9 studies	21% ± 3%	Explore
memory B cell	9 studies	21% ± 4%	Explore
endothelial cell of vascular tree	9 studies	35% ± 13%	Explore
non-classical monocyte	8 studies	25% ± 2%	Explore
microglial cell	8 studies	23% ± 8%	Explore
CD4-positive, alpha-beta T cell	8 studies	22% ± 5%	Explore
myofibroblast cell	8 studies	27% ± 12%	Explore
connective tissue cell	8 studies	25% ± 7%	Explore
myeloid cell	8 studies	29% ± 9%	Explore
naive B cell	7 studies	21% ± 4%	Explore
plasmacytoid dendritic cell	7 studies	21% ± 5%	Explore
type I pneumocyte	6 studies	20% ± 4%	Explore
mononuclear phagocyte	6 studies	31% ± 10%	Explore
oligodendrocyte precursor cell	6 studies	27% ± 9%	Explore
endothelial cell of lymphatic vessel	5 studies	25% ± 6%	Explore
hematopoietic precursor cell	5 studies	29% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	21% ± 4%	Explore
abnormal cell	5 studies	30% ± 8%	Explore
glutamatergic neuron	5 studies	38% ± 17%	Explore
hematopoietic stem cell	5 studies	22% ± 5%	Explore
vein endothelial cell	5 studies	31% ± 12%	Explore
gamma-delta T cell	5 studies	27% ± 12%	Explore
mature NK T cell	5 studies	21% ± 3%	Explore
mucosal invariant T cell	4 studies	18% ± 3%	Explore
precursor B cell	4 studies	28% ± 8%	Explore
innate lymphoid cell	4 studies	21% ± 2%	Explore
type II pneumocyte	4 studies	22% ± 7%	Explore
adipocyte	4 studies	24% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	17% ± 2%	Explore
endothelial cell of artery	4 studies	25% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	24% ± 6%	Explore
muscle cell	4 studies	32% ± 11%	Explore
GABAergic neuron	4 studies	37% ± 11%	Explore
leukocyte	4 studies	28% ± 8%	Explore
T follicular helper cell	4 studies	19% ± 2%	Explore
secretory cell	3 studies	19% ± 1%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
amacrine cell	3 studies	23% ± 4%	Explore
retinal bipolar neuron	3 studies	20% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 2%	Explore
common myeloid progenitor	3 studies	30% ± 19%	Explore
erythroblast	3 studies	31% ± 15%	Explore
lymphocyte	3 studies	24% ± 8%	Explore
pro-B cell	3 studies	28% ± 2%	Explore
club cell	3 studies	23% ± 7%	Explore
retinal pigment epithelial cell	3 studies	40% ± 14%	Explore
cardiac muscle cell	3 studies	21% ± 2%	Explore
tissue-resident macrophage	3 studies	30% ± 7%	Explore
ciliated cell	3 studies	27% ± 6%	Explore
Mueller cell	3 studies	27% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	23% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	25% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
brush cell	3 studies	37% ± 12%	Explore
goblet cell	3 studies	28% ± 5%	Explore
alveolar macrophage	3 studies	21% ± 4%	Explore
interneuron	3 studies	37% ± 20%	Explore
neuron	3 studies	39% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	32% ± 15%	Explore
lung	9 studies	20% ± 5%	Explore
intestine	5 studies	22% ± 9%	Explore
eye	5 studies	28% ± 11%	Explore
liver	5 studies	28% ± 13%	Explore
peripheral blood	4 studies	26% ± 13%	Explore
kidney	4 studies	22% ± 4%	Explore
uterus	4 studies	35% ± 2%	Explore
breast	4 studies	28% ± 7%	Explore
bone marrow	3 studies	17% ± 2%	Explore
esophagus	3 studies	27% ± 13%	Explore
lymph node	3 studies	19% ± 4%	Explore
prostate	3 studies	24% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	16204.78	1444 / 1445	100%	107.91	183 / 183
intestine	100%	17945.64	966 / 966	99%	105.56	523 / 527
lung	100%	17781.75	576 / 578	99%	102.21	1149 / 1155
ovary	100%	20771.21	180 / 180	99%	113.61	426 / 430
stomach	100%	18194.77	359 / 359	99%	100.89	283 / 286
breast	100%	14922.44	459 / 459	99%	134.56	1105 / 1118
pancreas	100%	33394.83	327 / 328	98%	119.06	175 / 178
skin	100%	16456.22	1800 / 1809	97%	106.84	459 / 472
brain	97%	10724.13	2565 / 2642	100%	207.45	702 / 705
bladder	100%	23276.24	21 / 21	97%	90.69	487 / 504
thymus	100%	38199.17	653 / 653	97%	121.91	584 / 605
prostate	100%	19718.40	245 / 245	96%	105.65	484 / 502
uterus	100%	15949.71	170 / 170	96%	105.76	439 / 459
kidney	100%	12311.87	89 / 89	96%	112.96	861 / 901
adrenal gland	100%	17439.64	258 / 258	92%	194.39	211 / 230
liver	83%	5243.60	188 / 226	80%	47.40	323 / 406
blood vessel	100%	21911.44	1335 / 1335	0%	0	0 / 0
spleen	100%	10927.37	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	20.92	1 / 1
adipose	100%	21570.09	1203 / 1204	0%	0	0 / 0
muscle	100%	16078.29	800 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	96%	94.73	77 / 80
tonsil	0%	0	0 / 0	96%	106.69	43 / 45
heart	95%	11706.72	815 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	91.21	26 / 29
peripheral blood	38%	4705.44	351 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0006730	Biological process	one-carbon metabolic process
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_0006556	Biological process	S-adenosylmethionine biosynthetic process
GO_0034214	Biological process	protein hexamerization
GO_0051291	Biological process	protein heterooligomerization
GO_0061431	Biological process	cellular response to methionine
GO_0048269	Cellular component	methionine adenosyltransferase complex
GO_0005829	Cellular component	cytosol
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0004478	Molecular function	methionine adenosyltransferase activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0036094	Molecular function	small molecule binding

IV. Literature review

[source]

Gene name	MAT2A
Protein name	S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) S-adenosylmethionine synthase (EC 2.5.1.6)
Synonyms	AMS2 MATA2 hCG_34602
Description	FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. . FUNCTION: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. .
Accessions	ENST00000409017.1 [P31153-2] B4DEX8 P31153 ENST00000306434.8 [P31153-1]

MAT2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review