LARS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	21 studies	24% ± 8%	Explore
B cell	12 studies	19% ± 3%	Explore
endothelial cell of lymphatic vessel	12 studies	22% ± 4%	Explore
fibroblast	12 studies	22% ± 7%	Explore
smooth muscle cell	12 studies	19% ± 2%	Explore
ciliated cell	12 studies	27% ± 11%	Explore
basal cell	10 studies	26% ± 12%	Explore
pericyte	10 studies	20% ± 4%	Explore
macrophage	9 studies	23% ± 7%	Explore
plasmacytoid dendritic cell	9 studies	27% ± 8%	Explore
naive B cell	8 studies	18% ± 3%	Explore
epithelial cell	8 studies	37% ± 17%	Explore
oligodendrocyte precursor cell	8 studies	33% ± 14%	Explore
GABAergic neuron	7 studies	37% ± 20%	Explore
endothelial cell of vascular tree	7 studies	19% ± 5%	Explore
oligodendrocyte	7 studies	32% ± 10%	Explore
hematopoietic precursor cell	6 studies	25% ± 10%	Explore
capillary endothelial cell	6 studies	19% ± 3%	Explore
glutamatergic neuron	6 studies	47% ± 24%	Explore
myofibroblast cell	6 studies	20% ± 3%	Explore
adipocyte	6 studies	25% ± 6%	Explore
vein endothelial cell	6 studies	20% ± 8%	Explore
astrocyte	6 studies	34% ± 11%	Explore
memory B cell	6 studies	18% ± 2%	Explore
natural killer cell	5 studies	21% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	18% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	18% ± 2%	Explore
CD4-positive, alpha-beta T cell	5 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
neuron	5 studies	31% ± 10%	Explore
myeloid cell	5 studies	23% ± 7%	Explore
conventional dendritic cell	4 studies	31% ± 13%	Explore
erythroblast	4 studies	29% ± 8%	Explore
precursor B cell	4 studies	23% ± 3%	Explore
lymphocyte	4 studies	23% ± 6%	Explore
secretory cell	4 studies	25% ± 7%	Explore
endothelial cell of artery	4 studies	17% ± 1%	Explore
dendritic cell	4 studies	29% ± 13%	Explore
hematopoietic stem cell	4 studies	25% ± 9%	Explore
goblet cell	4 studies	24% ± 8%	Explore
interneuron	4 studies	47% ± 21%	Explore
CD8-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
regulatory T cell	4 studies	19% ± 2%	Explore
microglial cell	4 studies	26% ± 8%	Explore
T cell	3 studies	18% ± 3%	Explore
mast cell	3 studies	23% ± 7%	Explore
classical monocyte	3 studies	22% ± 6%	Explore
non-classical monocyte	3 studies	21% ± 4%	Explore
club cell	3 studies	24% ± 4%	Explore
immature B cell	3 studies	21% ± 2%	Explore
type I pneumocyte	3 studies	21% ± 5%	Explore
type II pneumocyte	3 studies	25% ± 12%	Explore
progenitor cell	3 studies	23% ± 4%	Explore
retina horizontal cell	3 studies	22% ± 4%	Explore
abnormal cell	3 studies	36% ± 1%	Explore
muscle cell	3 studies	27% ± 7%	Explore
connective tissue cell	3 studies	22% ± 7%	Explore
granulocyte monocyte progenitor cell	3 studies	30% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	43% ± 18%	Explore
intestinal crypt stem cell	3 studies	22% ± 2%	Explore
leukocyte	3 studies	20% ± 2%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	17% ± 1%	Explore
gamma-delta T cell	3 studies	29% ± 18%	Explore
transit amplifying cell	3 studies	35% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	8 studies	39% ± 18%	Explore
peripheral blood	7 studies	21% ± 8%	Explore
lung	6 studies	23% ± 6%	Explore
eye	4 studies	24% ± 6%	Explore
adipose	4 studies	21% ± 5%	Explore
bone marrow	3 studies	18% ± 3%	Explore
liver	3 studies	32% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5491.21	1445 / 1445	100%	18.78	183 / 183
ovary	100%	6124.73	180 / 180	100%	15.56	430 / 430
prostate	100%	6007.95	245 / 245	100%	23.19	502 / 502
brain	100%	4641.49	2640 / 2642	100%	27.29	705 / 705
lung	100%	4851.87	578 / 578	100%	16.06	1153 / 1155
breast	100%	6220.07	459 / 459	100%	24.32	1116 / 1118
uterus	100%	6256.02	170 / 170	100%	17.51	458 / 459
stomach	100%	4275.04	359 / 359	100%	17.99	285 / 286
bladder	100%	6171.57	21 / 21	100%	15.81	502 / 504
pancreas	100%	4708.84	328 / 328	99%	14.82	177 / 178
intestine	100%	5561.64	966 / 966	99%	18.60	524 / 527
thymus	100%	6182.11	653 / 653	99%	16.92	601 / 605
kidney	100%	4009.45	89 / 89	99%	18.12	891 / 901
skin	100%	7240.79	1809 / 1809	98%	23.52	464 / 472
adrenal gland	100%	6090.79	258 / 258	97%	13.24	222 / 230
liver	100%	2157.78	225 / 226	92%	9.20	374 / 406
adipose	100%	5771.75	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5519.55	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	15.44	29 / 29
muscle	100%	7460.69	803 / 803	0%	0	0 / 0
spleen	100%	5529.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	19.05	45 / 45
ureter	0%	0	0 / 0	100%	4.01	1 / 1
heart	97%	4169.04	835 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	15.91	76 / 80
peripheral blood	77%	3023.29	713 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1990253	Biological process	cellular response to leucine starvation
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0006425	Biological process	glutaminyl-tRNA aminoacylation
GO_0006429	Biological process	leucyl-tRNA aminoacylation
GO_0006418	Biological process	tRNA aminoacylation for protein translation
GO_0034198	Biological process	cellular response to amino acid starvation
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0106074	Biological process	aminoacyl-tRNA metabolism involved in translational fidelity
GO_0008361	Biological process	regulation of cell size
GO_1904263	Biological process	positive regulation of TORC1 signaling
GO_0032008	Biological process	positive regulation of TOR signaling
GO_0071233	Biological process	cellular response to L-leucine
GO_0012505	Cellular component	endomembrane system
GO_0005764	Cellular component	lysosome
GO_0016604	Cellular component	nuclear body
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0017101	Cellular component	aminoacyl-tRNA synthetase multienzyme complex
GO_0004819	Molecular function	glutamine-tRNA ligase activity
GO_0005096	Molecular function	GTPase activator activity
GO_0005524	Molecular function	ATP binding
GO_0004823	Molecular function	leucine-tRNA ligase activity
GO_0002161	Molecular function	aminoacyl-tRNA editing activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LARS1
Protein name	leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) Leucine--tRNA ligase, cytoplasmic (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) (cLRS) Leucyl-tRNA synthetase 1
Synonyms	KIAA1352 LARS
Description	FUNCTION: Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)) . It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA . To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing) . .
Accessions	A0A6I8PIP7 A0A6I8PIT3 ENST00000674158.1 A0A6I8PLB3 Q0VGM8 ENST00000674270.1 A0A6I8PRP1 ENST00000510191.5 [Q9P2J5-2] ENST00000674398.1 ENST00000674467.1 ENST00000674447.1 ENST00000394434.7 [Q9P2J5-1] A0A6I8PRS0 A0A6I8PS05 A0A6I8PLB8 ENST00000674310.1 Q9P2J5 ENST00000674277.1 ENST00000674290.1 ENST00000674170.1 ENST00000674174.1 [Q9P2J5-2] B4DER1 ENST00000674309.1 ENST00000674181.1 Q6NVI4 A0A6I8PTV8 ENST00000674191.1 A0A6I8PRU9 A0A6I8PIV1 A0A6I8PL42

LARS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review