ISG20 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	44 studies	52% ± 17%	Explore
natural killer cell	41 studies	47% ± 14%	Explore
CD8-positive, alpha-beta T cell	39 studies	43% ± 15%	Explore
CD4-positive, alpha-beta T cell	33 studies	41% ± 12%	Explore
T cell	29 studies	44% ± 16%	Explore
plasma cell	28 studies	63% ± 24%	Explore
regulatory T cell	28 studies	59% ± 14%	Explore
memory B cell	20 studies	52% ± 13%	Explore
naive B cell	20 studies	57% ± 11%	Explore
mature NK T cell	19 studies	46% ± 12%	Explore
gamma-delta T cell	18 studies	45% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	45% ± 15%	Explore
mucosal invariant T cell	16 studies	43% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	46% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	43% ± 12%	Explore
plasmacytoid dendritic cell	14 studies	35% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	50% ± 14%	Explore
plasmablast	12 studies	75% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	52% ± 17%	Explore
non-classical monocyte	12 studies	27% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	43% ± 14%	Explore
conventional dendritic cell	11 studies	27% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	51% ± 20%	Explore
dendritic cell	9 studies	29% ± 9%	Explore
endothelial cell	9 studies	22% ± 8%	Explore
ciliated cell	9 studies	33% ± 19%	Explore
IgG plasma cell	9 studies	59% ± 17%	Explore
T follicular helper cell	9 studies	47% ± 12%	Explore
innate lymphoid cell	9 studies	42% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	46% ± 14%	Explore
IgA plasma cell	8 studies	59% ± 19%	Explore
type I pneumocyte	7 studies	26% ± 13%	Explore
leukocyte	7 studies	33% ± 12%	Explore
epithelial cell	7 studies	45% ± 13%	Explore
basal cell	7 studies	32% ± 13%	Explore
CD4-positive helper T cell	6 studies	43% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	35% ± 14%	Explore
macrophage	6 studies	24% ± 9%	Explore
secretory cell	6 studies	37% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	57% ± 11%	Explore
goblet cell	6 studies	19% ± 5%	Explore
capillary endothelial cell	6 studies	25% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	53% ± 10%	Explore
endothelial cell of vascular tree	6 studies	34% ± 16%	Explore
exhausted T cell	5 studies	58% ± 17%	Explore
monocyte	5 studies	24% ± 11%	Explore
classical monocyte	5 studies	28% ± 9%	Explore
precursor B cell	5 studies	42% ± 12%	Explore
enterocyte	5 studies	21% ± 4%	Explore
immature B cell	5 studies	53% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	42% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	42% ± 18%	Explore
club cell	4 studies	25% ± 8%	Explore
neutrophil	4 studies	25% ± 5%	Explore
myeloid cell	4 studies	26% ± 9%	Explore
double negative thymocyte	4 studies	67% ± 12%	Explore
germinal center B cell	4 studies	53% ± 17%	Explore
fibroblast	4 studies	27% ± 13%	Explore
IgM plasma cell	4 studies	55% ± 24%	Explore
T-helper 17 cell	4 studies	41% ± 18%	Explore
abnormal cell	4 studies	38% ± 24%	Explore
respiratory goblet cell	3 studies	39% ± 18%	Explore
mononuclear phagocyte	3 studies	36% ± 5%	Explore
lymphocyte	3 studies	29% ± 4%	Explore
pro-B cell	3 studies	26% ± 3%	Explore
intraepithelial lymphocyte	3 studies	33% ± 3%	Explore
endothelial cell of artery	3 studies	25% ± 6%	Explore
vein endothelial cell	3 studies	27% ± 1%	Explore
luminal cell of prostate epithelium	3 studies	40% ± 5%	Explore
monocyte-derived dendritic cell	3 studies	39% ± 11%	Explore
T-helper 1 cell	3 studies	47% ± 20%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	53% ± 9%	Explore
erythrocyte	3 studies	27% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	38% ± 10%	Explore
lung	9 studies	29% ± 6%	Explore
lymph node	5 studies	45% ± 16%	Explore
bone marrow	4 studies	25% ± 8%	Explore
intestine	4 studies	41% ± 14%	Explore
uterus	4 studies	24% ± 7%	Explore
prostate	4 studies	29% ± 4%	Explore
breast	4 studies	26% ± 7%	Explore
liver	4 studies	30% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	2086.71	577 / 578	97%	14.46	1121 / 1155
thymus	100%	1198.67	651 / 653	95%	13.57	574 / 605
stomach	98%	1388.07	353 / 359	95%	11.12	271 / 286
breast	98%	789.18	452 / 459	91%	10.78	1022 / 1118
prostate	96%	750.98	235 / 245	83%	7.50	416 / 502
intestine	82%	1015.02	794 / 966	95%	12.67	499 / 527
uterus	82%	355.92	140 / 170	90%	16.29	412 / 459
ovary	94%	645.72	170 / 180	77%	6.72	332 / 430
esophagus	80%	505.54	1161 / 1445	89%	12.71	163 / 183
liver	82%	521.46	185 / 226	78%	7.79	317 / 406
bladder	71%	330.29	15 / 21	75%	9.42	377 / 504
kidney	66%	497.43	59 / 89	74%	5.16	664 / 901
skin	61%	238.20	1105 / 1809	78%	16.90	370 / 472
pancreas	46%	151.97	151 / 328	93%	18.91	166 / 178
lymph node	0%	0	0 / 0	100%	106.10	29 / 29
spleen	100%	5281.70	241 / 241	0%	0	0 / 0
peripheral blood	100%	4909.32	928 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	20.37	44 / 45
adipose	96%	656.99	1160 / 1204	0%	0	0 / 0
blood vessel	81%	354.68	1077 / 1335	0%	0	0 / 0
adrenal gland	48%	188.35	123 / 258	29%	2.11	66 / 230
brain	28%	126.02	728 / 2642	29%	2.13	206 / 705
heart	52%	242.21	447 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	33%	3.62	26 / 80
muscle	11%	31.94	88 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0045071	Biological process	negative regulation of viral genome replication
GO_0045087	Biological process	innate immune response
GO_0009615	Biological process	response to virus
GO_0051607	Biological process	defense response to virus
GO_0006308	Biological process	DNA catabolic process
GO_0006401	Biological process	RNA catabolic process
GO_0006364	Biological process	rRNA processing
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0000932	Cellular component	P-body
GO_0016605	Cellular component	PML body
GO_0005737	Cellular component	cytoplasm
GO_0015030	Cellular component	Cajal body
GO_0005634	Cellular component	nucleus
GO_0034511	Molecular function	U3 snoRNA binding
GO_0004527	Molecular function	exonuclease activity
GO_0030619	Molecular function	U1 snRNA binding
GO_0008310	Molecular function	single-stranded DNA 3'-5' DNA exonuclease activity
GO_0046872	Molecular function	metal ion binding
GO_0030620	Molecular function	U2 snRNA binding
GO_0000175	Molecular function	3'-5'-RNA exonuclease activity
GO_0008859	Molecular function	exoribonuclease II activity

IV. Literature review

[source]

Gene name	ISG20
Protein name	Interferon stimulated exonuclease gene 20 Interferon-stimulated gene 20 kDa protein (EC 3.1.13.1) (Estrogen-regulated transcript 45 protein) (Promyelocytic leukemia nuclear body-associated protein ISG20) Interferon-stimulated gene 20 kDa protein
Synonyms	HEM45
Description	FUNCTION: Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA . Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) . Inhibition of several viruses such as chikungunya virus (CHIKV) does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins (By similarity). Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies . May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (By similarity). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis . .
Accessions	ENST00000306072.10 [Q96AZ6-1] Q96AZ6 ENST00000559876.2 H0YMM4 H3BLY5 ENST00000379224.10 [Q96AZ6-1] ENST00000379224 ENST00000560741.5 [Q96AZ6-1]

ISG20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review