IRAK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_1990266Biological processneutrophil migration
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0007254Biological processJNK cascade
GO_0045087Biological processinnate immune response
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0038172Biological processinterleukin-33-mediated signaling pathway
GO_0002446Biological processneutrophil mediated immunity
GO_0035556Biological processintracellular signal transduction
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0008063Biological processToll signaling pathway
GO_0034162Biological processtoll-like receptor 9 signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0019897Cellular componentextrinsic component of plasma membrane
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0005149Molecular functioninterleukin-1 receptor binding
GO_0019901Molecular functionprotein kinase binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIRAK4
Protein nameInterleukin 1 receptor associated kinase 4 (Interleukin-1 receptor-associated kinase 4 isoform 2)
Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)
Interleukin 1 receptor associated kinase 4
Interleukin-1 receptor associated kinase 4 mutant form 2
Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1)
SynonymshCG_39494
DescriptionFUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways . Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. .

FUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. .

FUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. .

AccessionsENST00000551736.5 [Q9NWZ3-1]
A0A8Q3SIT8
Q9NWZ3
F8VR40
ENST00000550386.5
ENST00000552309.5
F8VW24
A0A8Q3SIY0
Q7Z6A8
ENST00000550616.5
Q69FE3
ENST00000613694.5 [Q9NWZ3-1]
ENST00000550615.5
ENST00000547521.5
ENST00000696791.1
ENST00000696795.1
F8VVZ1
ENST00000440781.6 [Q9NWZ3-2]
ENST00000696790.1
Q7Z6A7
ENST00000696796.1
ENST00000696792.1
ENST00000550361.1
ENST00000547101.5