IDS | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	30% ± 10%	Explore
CD8-positive, alpha-beta T cell	27 studies	33% ± 11%	Explore
B cell	26 studies	31% ± 9%	Explore
T cell	23 studies	28% ± 12%	Explore
CD4-positive, alpha-beta T cell	22 studies	33% ± 13%	Explore
mast cell	20 studies	44% ± 15%	Explore
regulatory T cell	19 studies	33% ± 11%	Explore
memory B cell	18 studies	33% ± 13%	Explore
mature NK T cell	17 studies	33% ± 9%	Explore
ciliated cell	17 studies	32% ± 12%	Explore
gamma-delta T cell	16 studies	35% ± 14%	Explore
plasmacytoid dendritic cell	16 studies	43% ± 16%	Explore
macrophage	15 studies	20% ± 4%	Explore
classical monocyte	15 studies	27% ± 11%	Explore
fibroblast	13 studies	25% ± 8%	Explore
smooth muscle cell	13 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	29% ± 11%	Explore
conventional dendritic cell	13 studies	26% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	39% ± 12%	Explore
naive B cell	13 studies	30% ± 13%	Explore
mucosal invariant T cell	12 studies	35% ± 13%	Explore
pericyte	11 studies	22% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	36% ± 13%	Explore
non-classical monocyte	11 studies	33% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	24% ± 11%	Explore
endothelial cell	11 studies	30% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	39% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	30% ± 12%	Explore
dendritic cell	9 studies	31% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	38% ± 18%	Explore
monocyte	8 studies	22% ± 6%	Explore
astrocyte	8 studies	27% ± 8%	Explore
glutamatergic neuron	8 studies	71% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	31% ± 13%	Explore
oligodendrocyte	7 studies	28% ± 10%	Explore
hematopoietic stem cell	7 studies	33% ± 9%	Explore
T follicular helper cell	7 studies	37% ± 17%	Explore
type I pneumocyte	6 studies	30% ± 6%	Explore
CD4-positive helper T cell	6 studies	32% ± 22%	Explore
amacrine cell	6 studies	40% ± 17%	Explore
microglial cell	6 studies	26% ± 7%	Explore
myeloid cell	6 studies	30% ± 12%	Explore
epithelial cell	6 studies	30% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	31% ± 5%	Explore
neutrophil	5 studies	21% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	37% ± 13%	Explore
GABAergic neuron	5 studies	60% ± 28%	Explore
retinal ganglion cell	5 studies	65% ± 25%	Explore
retina horizontal cell	5 studies	40% ± 15%	Explore
alveolar macrophage	5 studies	18% ± 4%	Explore
innate lymphoid cell	5 studies	35% ± 13%	Explore
oligodendrocyte precursor cell	5 studies	22% ± 5%	Explore
interneuron	5 studies	56% ± 31%	Explore
plasma cell	4 studies	27% ± 9%	Explore
leukocyte	4 studies	38% ± 16%	Explore
exhausted T cell	4 studies	29% ± 3%	Explore
neuron	4 studies	54% ± 21%	Explore
retinal bipolar neuron	4 studies	38% ± 15%	Explore
abnormal cell	4 studies	33% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	38% ± 14%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	21% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	30% ± 9%	Explore
ionocyte	3 studies	30% ± 2%	Explore
squamous epithelial cell	3 studies	41% ± 22%	Explore
platelet	3 studies	21% ± 7%	Explore
pancreatic A cell	3 studies	84% ± 11%	Explore
pancreatic D cell	3 studies	86% ± 15%	Explore
type B pancreatic cell	3 studies	76% ± 21%	Explore
mononuclear phagocyte	3 studies	23% ± 3%	Explore
plasmablast	3 studies	31% ± 13%	Explore
GABAergic interneuron	3 studies	46% ± 17%	Explore
glycinergic amacrine cell	3 studies	27% ± 11%	Explore
lymphocyte	3 studies	27% ± 14%	Explore
myofibroblast cell	3 studies	22% ± 2%	Explore
basal cell	3 studies	20% ± 1%	Explore
OFF-bipolar cell	3 studies	36% ± 14%	Explore
ON-bipolar cell	3 studies	42% ± 16%	Explore
rod bipolar cell	3 studies	28% ± 10%	Explore
granulocyte	3 studies	36% ± 15%	Explore
enteroendocrine cell	3 studies	37% ± 13%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 19%	Explore
T-helper 17 cell	3 studies	49% ± 16%	Explore
connective tissue cell	3 studies	22% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	31% ± 12%	Explore
brain	13 studies	44% ± 24%	Explore
lung	10 studies	25% ± 7%	Explore
eye	6 studies	24% ± 6%	Explore
intestine	5 studies	22% ± 7%	Explore
lymph node	5 studies	25% ± 9%	Explore
uterus	4 studies	24% ± 5%	Explore
pancreas	3 studies	64% ± 26%	Explore
kidney	3 studies	26% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	98%	9651.10	1409 / 1445	99%	4.41	182 / 183
brain	100%	68990.80	2641 / 2642	94%	6.43	660 / 705
lung	99%	11927.39	571 / 578	94%	3.77	1087 / 1155
ovary	100%	14217.24	180 / 180	90%	2.90	386 / 430
skin	99%	9125.15	1790 / 1809	89%	3.13	421 / 472
breast	100%	10182.07	458 / 459	86%	2.55	962 / 1118
intestine	97%	10110.16	941 / 966	83%	2.39	436 / 527
thymus	99%	10818.51	648 / 653	81%	2.91	488 / 605
bladder	100%	10794.48	21 / 21	74%	1.75	375 / 504
prostate	100%	11525.48	244 / 245	74%	1.71	373 / 502
kidney	94%	7056.81	84 / 89	79%	2.76	713 / 901
adrenal gland	90%	6131.05	232 / 258	80%	7.77	184 / 230
uterus	100%	13462.45	170 / 170	67%	1.65	309 / 459
stomach	64%	5261.44	228 / 359	92%	4.11	263 / 286
pancreas	41%	2159.30	135 / 328	92%	3.16	164 / 178
spleen	100%	8228.46	241 / 241	0%	0	0 / 0
blood vessel	100%	20823.72	1333 / 1335	0%	0	0 / 0
adipose	99%	9714.41	1189 / 1204	0%	0	0 / 0
peripheral blood	94%	12016.91	870 / 929	0%	0	0 / 0
heart	90%	8552.00	774 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	82%	2.11	37 / 45
lymph node	0%	0	0 / 0	59%	2.24	17 / 29
muscle	58%	3011.26	469 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	57%	0.99	46 / 80
liver	11%	488.70	25 / 226	20%	0.45	82 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0030209	Biological process	dermatan sulfate catabolic process
GO_0030200	Biological process	heparan sulfate proteoglycan catabolic process
GO_0006027	Biological process	glycosaminoglycan catabolic process
GO_0043202	Cellular component	lysosomal lumen
GO_0005764	Cellular component	lysosome
GO_0005737	Cellular component	cytoplasm
GO_0004423	Molecular function	iduronate-2-sulfatase activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IDS
Protein name	Iduronate 2-sulfatase (Hunter syndrome), isoform CRA_e (cDNA FLJ42669 fis, clone BRAMY2022168, highly similar to IDURONATE 2-SULFATASE) Iduronate 2-sulfatase Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] Iduronate-2-sulphatase Alternative protein IDS
Synonyms	hCG_1993933 SIDS
Description	FUNCTION: Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. .
Accessions	ENST00000521702.1 ENST00000422081.6 L8E9D7 ENST00000340855.11 [P22304-1] P22304 E5RHJ1 A0A286S6N5 ENST00000428056.6 ENST00000370441.8 [P22304-2] H0YB91 ENST00000466323.5 [P22304-3] B3KWA1 O60597 Q14603 ENST00000651111.1 A0A286RZ48 A0A286RZ44 ENST00000464251.5

IDS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review