Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 7745.40 | 578 / 578 | 87% | 100.65 | 1009 / 1155 |
| breast | 98% | 2229.34 | 448 / 459 | 89% | 76.56 | 1000 / 1118 |
| kidney | 97% | 1720.82 | 86 / 89 | 85% | 98.55 | 765 / 901 |
| thymus | 86% | 1337.82 | 563 / 653 | 77% | 60.84 | 466 / 605 |
| skin | 71% | 1168.51 | 1279 / 1809 | 73% | 85.04 | 344 / 472 |
| prostate | 82% | 947.07 | 200 / 245 | 58% | 21.25 | 292 / 502 |
| intestine | 78% | 1611.30 | 754 / 966 | 59% | 38.37 | 309 / 527 |
| bladder | 76% | 775.57 | 16 / 21 | 58% | 42.07 | 294 / 504 |
| uterus | 71% | 702.76 | 120 / 170 | 63% | 52.42 | 287 / 459 |
| esophagus | 73% | 673.28 | 1055 / 1445 | 56% | 28.60 | 102 / 183 |
| stomach | 47% | 461.02 | 167 / 359 | 67% | 50.39 | 191 / 286 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 496.32 | 29 / 29 |
| spleen | 100% | 8234.54 | 241 / 241 | 0% | 0 | 0 / 0 |
| ovary | 27% | 197.16 | 49 / 180 | 72% | 50.99 | 311 / 430 |
| adrenal gland | 72% | 911.70 | 185 / 258 | 27% | 7.95 | 63 / 230 |
| adipose | 96% | 2454.95 | 1151 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 12% | 100.09 | 39 / 328 | 83% | 61.28 | 147 / 178 |
| tonsil | 0% | 0 | 0 / 0 | 91% | 94.28 | 41 / 45 |
| peripheral blood | 90% | 10844.28 | 839 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 85% | 1704.27 | 1135 / 1335 | 0% | 0 | 0 / 0 |
| liver | 24% | 178.03 | 54 / 226 | 39% | 18.40 | 160 / 406 |
| brain | 21% | 232.28 | 550 / 2642 | 38% | 22.06 | 271 / 705 |
| heart | 40% | 298.13 | 345 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 29% | 14.76 | 23 / 80 |
| muscle | 18% | 113.30 | 142 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050870 | Biological process | positive regulation of T cell activation |
| GO_0002503 | Biological process | peptide antigen assembly with MHC class II protein complex |
| GO_0006955 | Biological process | immune response |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0019886 | Biological process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO_0050778 | Biological process | positive regulation of immune response |
| GO_0031902 | Cellular component | late endosome membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0030666 | Cellular component | endocytic vesicle membrane |
| GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
| GO_0032588 | Cellular component | trans-Golgi network membrane |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0098553 | Cellular component | lumenal side of endoplasmic reticulum membrane |
| GO_0042613 | Cellular component | MHC class II protein complex |
| GO_0012507 | Cellular component | ER to Golgi transport vesicle membrane |
| GO_0030658 | Cellular component | transport vesicle membrane |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0023026 | Molecular function | MHC class II protein complex binding |
| GO_0032395 | Molecular function | MHC class II receptor activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0042605 | Molecular function | peptide antigen binding |
| Gene name | HLA-DQA1 |
| Protein name | HLA class II histocompatibility antigen DQ alpha chain (MHC class I antigen) (MHC class II antigen) (MHC class II protein) Major histocompatibility complex, class II, DQ alpha 1 HLA class II histocompatibility antigen DQ alpha chain (HLA class II histocompatibility antigen, DQ alpha 1 chain) (MHC class II antigen) (MHC class II protein) HLA class II histocompatibility antigen DQ alpha chain (MHC class II DQ alpha) (MHC class II antigen) HMC class II surface glycoprotein Major histocompatibility complex class_II DQ alpha 1 MHC class II antigen HLA-DQA1 HLA class II histocompatibility antigen, DQ alpha 1 chain (DC-1 alpha chain) (DC-alpha) (HLA-DCA) (MHC class II DQA1) MHC class II HLA-DQ-alpha chain (MHC class II antigen) HLA-DQA1 protein HLA class II histocompatibility antigen DQ alpha chain HLA class II histocompatibility antigen DQ alpha chain (HLA-DQA1 protein) (MHC class II antigen) HLA class II histocompatibility antigen, DQ alpha 1 chain MHC class II DQ alpha chain MHC class II surface glycoprotein MHC class II antigen MHC class II HLA-DQ-alpha-1 MHC class I antigen HLA class II histocompatibility antigen DQ alpha chain (MHC class II antigen) (MHC class II protein) HLA class II histocompatibility antigen DQ alpha chain (MHC class II antigen) MHC class II HLA-DQ-alpha chain HLA class II histocompatibility antigen DQ alpha chain (HLA class II histocompatibility antigen, DQ alpha 1 chain) (HLA-DQA1 protein) (MHC class II antigen) |
| Synonyms | DQA1 |
| Description | FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. |
| Accessions | Q67AC3 Q67AE8 Q8MH31 Q67AF0 A0A3S6RHR8 A0A5A4LKR4 Q67AD3 A0A7T8G1R0 Q8MH24 A0A1W2PP70 A0A6B9RYM5 Q8MH39 A0A8E4NGM8 A0A8F4G902 A0A7T8GDC6 A0A7D7L7R7 ENST00000422863 Q8MH21 A0A182DWH1 Q8MH06 A0A1Z1XFJ9 Q67AI1 A0A858LK01 Q67AB9 Q5Y7H0 Q8MH37 Q8MH40 Q67AG3 A0A5H2UUN7 Q8MH03 Q8MH38 A0A7D5BS20 Q67A95 Q8MH07 A0A678ZGC3 A0A7T8GDD0 Q30066 A0A455QYR6 Q67AF4 Q67AC4 Q8MH08 Q8MH02 Q67AA2 Q8MH17 A0A6B7G1G7 A0A6M8DIF8 Q67AG1 O19765 Q67AB4 A0A6B7G1Y8 Q8MH01 ENST00000448163.1 Q67AB6 G4XQK3 Q8MH15 A0A3S6RJF9 A0A678ZHW9 M5FMQ4 A0A0C7DW92 A0A3S8IFE0 A0A4P8JC38 Q8MH51 ENST00000399675.5 A0A678ZGI9 Q08AS3 A0A678ZW57 A0A858LFR1 A0A678ZWF7 Q8MH16 H6X377 Q29882 A0A2U7N9W5 A0A649ZUY6 Q8MH50 A0A6H1PSA9 Q67A99 A0A678ZG88 Q8MH18 ENST00000453504.5 A0A5H2V0U4 Q8MH54 A0A4Y5R8Q2 Q67AG6 Q8MH30 A0A5B9R1D9 Q67AE1 A0A5H2UH72 A0A8F5FT89 A0A6B7G271 Q8MH56 A0A678ZW64 Q67AE4 Q67AA9 Q8MH55 Q5Y7C3 A0A6B7KQH6 Q67AD2 Q67AC2 Q67AA1 A0A6B7HG15 ENST00000450960.1 A0A6B7G1R8 A0A8E4J687 Q9UEF5 A0A4P8DL21 ENST00000374949.2 A0A6G8IQI4 A0A6B7G1F5 Q2LIR1 ENST00000383251.6 A0A6B7HG83 A0A678ZLJ4 Q8MH33 A0A6B7IDI5 A0A455JW02 Q30065 A0A678ZHY1 I7L1P1 A0A5Q2WVP2 Q67AD1 Q67AB7 Q67A92 A0A7L4X8M8 A0A8E4NFB8 A0A8G0VL53 A0A5H2UEZ6 A0A6B7HHD8 Q30069 ENST00000420385.5 A0A3S6RHR1 I7LP05 Q8MH13 A0A7T8GDZ4 Q67AD9 P01909 A0A8E4J479 ENST00000461508.5 A0A7L7TQL3 Q8MH29 A0A1W2HC18 A0A141R7F8 Q8MH52 A0A8F7GNM9 Q8MH42 Q67AF9 A0A4P2SUF7 A0A6B7HFM0 A0A3S6RHR2 Q67AH0 A0A6B7IAK8 Q8MH27 A0A6B7G290 A0A410JA83 Q67AG5 Q67AC9 A0A6B7HFD7 Q67AH7 Q67AA6 A0A5J6NUS7 Q67AC1 ENST00000445944.1 A0A6B7G4D2 ENST00000442680.1 Q67AD7 Q67AH4 A0A678ZKF3 Q8MH32 A0A678ZZ02 Q67AA8 Q8MH45 A0A173ADH0 A0A5P9WD20 ENST00000482745.5 Q861G0 ENST00000343139.11 Q67A94 A0A6B7ICQ8 Q08AS4 Q67AE6 A0A649ZUJ5 Q14K63 A0A346MPT6 A0A6G8IQH0 O19703 Q5Y7C6 Q8MH36 Q67AE3 A0A6B7G185 A0A7D5GWQ8 A0A6B7IAL1 Q14K62 Q2LIQ8 Q67AB8 A0A5P8NFE2 Q67AI6 ENST00000443320.5 A0A8E4NGV0 Q67AH9 A0A6B9RUU3 Q67AE7 Q67AI0 A0A678ZVH1 Q67AE5 Q8MH34 A0A5H2UU28 A0A2K9UYT9 Q8MH23 A0A5H2UYB9 A0A6B7HG57 Q8MH44 Q67AC7 A0A649ZU79 A0A7L4X7A7 Q67AB2 A0A346ASF5 Q67AA7 Q8MH12 Q67AG8 A0A649ZVH5 A0A140HDC1 O19704 Q67A93 A0A182DWH0 A0A4P8JAI3 A0A678ZGK1 ENST00000416403.5 A0A5H2UHY6 Q67AI4 S6E000 A0A6B7IDP4 A0A891XNZ3 A0A7D3QX10 A0A6M8E0G5 Q8MH09 Q8MH10 A0A8A8S9C7 A0A4P8NGF6 A0A649ZV55 A0A2H4RN65 Q8MH35 A0A8F5FTG8 A0A6B7G1E8 ENST00000468299.5 Q67AG9 Q67AE0 Q8MH19 E9PMV2 Q67AH8 ENST00000484643.5 A0A5B9QYQ8 Q5Y7F8 A0A6B7HG03 A0A7T8GE76 O19705 Q8MH25 Q67AF2 A0A2U7N6X6 F6UB03 A0A7G8KPP6 Q8MH22 A0A7U3UJY8 D0V3Q3 Q67AC0 A0A6B7HG71 A0A4Y5R8N7 ENST00000418023.5 A0A5P8NFP0 Q67AF3 Q67AG0 Q67AG2 A0A649ZUV0 Q30085 Q67AB0 A0A6B7HG10 Q67AE9 Q67AE2 A0A7L4X7A4 Q67AA5 A0A5P8NK25 Q67AH3 A0A8F7GPX2 ENST00000457246.6 A0A678ZZ17 A0A678ZVH6 ENST00000496318.5 Q67AD4 A0A6B7HHG1 A0A346FLH4 Q6DKG8 Q67AF1 A0A6M8DQ68 ENST00000456258.6 A0A7S5GSG0 A0A7S7BBP3 O19501 A0A7L7TRI7 A0A6M8DGF5 A0A8F2Q4A3 Q67A97 Q67AH1 A0A858B7J8 Q67AH6 Q67AH5 I7KE75 A0A4P2SSR0 Q67AD0 A0A5H2UYL3 E9PI37 Q67AD6 A0A5A4LHJ0 A0A5J6D2Z6 A0A141R7F9 ENST00000451947.6 A0A7D3QYF6 Q8MH26 ENST00000640446.1 A0A6G8IQS5 A0A7T8GEM3 A0A7L4X7G7 L8E864 Q8MH28 A0A6B7IBD0 A0A7T8GED3 A0A7D3V690 Q67AC5 Q67AA0 ENST00000414549.1 A0A3S6RHS9 Q8MH41 Q67AG4 Q67AB1 Q8MH11 Q67AI2 A0A6B7G4C3 A0A6G8IQZ5 A0A7H0TJC5 A0A5H2USX1 A0A5J6DL13 Q8MH05 A0A678ZGD2 A0A678ZKE1 Q67AG7 A0A5A4LM74 Q67AC8 Q5Y7G1 A0A182DWF8 A0A7L4X6R2 Q8MH43 A0A6B7IC72 Q67AF8 A0A6B7G317 Q67AD5 A0A6B7G1H6 Q14K64 A0A858B8G4 A0A0G2JKJ3 A0A5B9RAZ7 A0A858B8H4 A0A2U7MWQ9 Q67A96 Q67AB5 A0A896YBD6 Q8MH14 A0A7D5HAT0 L8EB08 A0A6B7L1Q7 Q67AF7 A0A6G8IQJ7 Q67AH2 Q5Y7C9 A0A6B7G4W2 A0A6B7G295 A0A6M6CFV8 Q67AD8 A0A8F5J0A6 Q8MH53 Q67AF5 A0A2K9UYU0 A0A8F7GNE3 Q67AC6 ENST00000442315.5 Q8MH00 Q8MH04 A0A5P8NFL4 A0A6M8DWG3 O19760 ENST00000399678.5 A0A455R111 A0A5A4LJP2 Q8MH20 A0A678ZWG2 A0A8F9WBB2 A0A678ZLM8 A0A2U7NN70 A0A8E4J4A3 A0A896SZE0 Q67A98 A0A4P8JAG8 A0A8E4J5S8 Q67AA3 Q67AF6 ENST00000450614.5 A0A6G8IQY1 Q5Y7A8 ENST00000395363.5 A0A5J6NRT4 ENST00000441297.5 ENST00000444296.6 A0A5B9R1P1 A0A678ZGA0 A0A4P2SSM2 A0A0U4C4L3 Q67AB3 A0A8E4NFW7 Q67AA4 A0A173ADG5 A0A5H2UEB6 A0A6G8IQL3 A0A140TA20 A0A6B7G1Y1 Q67AI5 Q67AI3 D5H3J4 G4XQK2 |
