HELZ report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	29 studies	29% ± 9%	Explore
endothelial cell	23 studies	35% ± 17%	Explore
macrophage	19 studies	35% ± 19%	Explore
T cell	16 studies	24% ± 8%	Explore
astrocyte	15 studies	37% ± 17%	Explore
fibroblast	15 studies	28% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	31% ± 8%	Explore
oligodendrocyte precursor cell	14 studies	38% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	31% ± 10%	Explore
microglial cell	13 studies	46% ± 13%	Explore
classical monocyte	12 studies	24% ± 10%	Explore
CD8-positive, alpha-beta T cell	12 studies	24% ± 6%	Explore
mucosal invariant T cell	12 studies	25% ± 7%	Explore
glutamatergic neuron	11 studies	43% ± 25%	Explore
gamma-delta T cell	11 studies	23% ± 7%	Explore
oligodendrocyte	11 studies	27% ± 12%	Explore
GABAergic neuron	10 studies	45% ± 23%	Explore
mature NK T cell	10 studies	24% ± 10%	Explore
myeloid cell	10 studies	31% ± 10%	Explore
CD4-positive, alpha-beta T cell	9 studies	25% ± 7%	Explore
epithelial cell	9 studies	39% ± 20%	Explore
adipocyte	9 studies	46% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	24% ± 8%	Explore
monocyte	8 studies	31% ± 10%	Explore
B cell	7 studies	25% ± 6%	Explore
basal cell	7 studies	32% ± 22%	Explore
type I pneumocyte	7 studies	30% ± 13%	Explore
pericyte	7 studies	28% ± 9%	Explore
neuron	6 studies	39% ± 13%	Explore
interneuron	6 studies	51% ± 24%	Explore
club cell	6 studies	28% ± 11%	Explore
retina horizontal cell	6 studies	30% ± 14%	Explore
retinal cone cell	6 studies	30% ± 13%	Explore
dendritic cell	6 studies	31% ± 8%	Explore
mast cell	6 studies	24% ± 10%	Explore
type II pneumocyte	6 studies	31% ± 9%	Explore
smooth muscle cell	6 studies	28% ± 7%	Explore
non-classical monocyte	5 studies	26% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	20% ± 4%	Explore
regulatory T cell	5 studies	19% ± 3%	Explore
amacrine cell	5 studies	26% ± 9%	Explore
ciliated cell	5 studies	33% ± 11%	Explore
Mueller cell	5 studies	29% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	17% ± 3%	Explore
innate lymphoid cell	5 studies	21% ± 4%	Explore
endothelial cell of lymphatic vessel	5 studies	33% ± 13%	Explore
leukocyte	5 studies	30% ± 15%	Explore
granule cell	4 studies	28% ± 3%	Explore
retinal ganglion cell	4 studies	33% ± 15%	Explore
naive B cell	4 studies	16% ± 1%	Explore
retinal pigment epithelial cell	4 studies	31% ± 17%	Explore
cardiac muscle cell	4 studies	33% ± 3%	Explore
lymphocyte	4 studies	44% ± 15%	Explore
retinal rod cell	4 studies	34% ± 8%	Explore
hepatocyte	4 studies	60% ± 17%	Explore
goblet cell	4 studies	35% ± 28%	Explore
hematopoietic precursor cell	3 studies	30% ± 8%	Explore
GABAergic interneuron	3 studies	36% ± 3%	Explore
glial cell	3 studies	24% ± 8%	Explore
plasma cell	3 studies	33% ± 2%	Explore
mesothelial cell	3 studies	30% ± 13%	Explore
mononuclear phagocyte	3 studies	31% ± 2%	Explore
retinal bipolar neuron	3 studies	19% ± 3%	Explore
GABAergic amacrine cell	3 studies	29% ± 12%	Explore
OFF-bipolar cell	3 studies	28% ± 12%	Explore
ON-bipolar cell	3 studies	27% ± 10%	Explore
glycinergic amacrine cell	3 studies	26% ± 7%	Explore
rod bipolar cell	3 studies	27% ± 13%	Explore
endothelial cell of vascular tree	3 studies	27% ± 14%	Explore
abnormal cell	3 studies	32% ± 20%	Explore
ependymal cell	3 studies	35% ± 18%	Explore
alveolar macrophage	3 studies	38% ± 10%	Explore
capillary endothelial cell	3 studies	23% ± 6%	Explore
respiratory goblet cell	3 studies	31% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 7%	Explore
plasmacytoid dendritic cell	3 studies	19% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	22% ± 6%	Explore
mural cell	3 studies	39% ± 15%	Explore
mucus secreting cell	3 studies	28% ± 10%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	16 studies	37% ± 19%	Explore
lung	9 studies	24% ± 9%	Explore
peripheral blood	8 studies	23% ± 8%	Explore
eye	7 studies	31% ± 17%	Explore
heart	4 studies	26% ± 4%	Explore
liver	4 studies	37% ± 15%	Explore
adipose	4 studies	32% ± 12%	Explore
intestine	3 studies	19% ± 3%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3257.84	1445 / 1445	100%	19.44	183 / 183
brain	100%	2566.49	2636 / 2642	100%	14.31	705 / 705
lung	100%	4934.35	578 / 578	99%	13.73	1148 / 1155
breast	100%	4219.80	459 / 459	99%	17.66	1108 / 1118
intestine	100%	3883.27	966 / 966	98%	10.25	515 / 527
prostate	100%	3650.91	245 / 245	97%	11.21	489 / 502
thymus	100%	4773.98	653 / 653	97%	10.13	589 / 605
skin	100%	3361.49	1807 / 1809	97%	16.19	460 / 472
stomach	100%	2960.40	359 / 359	97%	13.04	278 / 286
pancreas	100%	2437.34	328 / 328	97%	9.82	173 / 178
bladder	100%	3698.71	21 / 21	97%	10.28	488 / 504
ovary	100%	5435.58	180 / 180	97%	9.36	416 / 430
uterus	100%	4547.68	170 / 170	97%	11.03	444 / 459
kidney	100%	2439.67	89 / 89	96%	12.10	861 / 901
adrenal gland	100%	3786.04	258 / 258	92%	7.69	212 / 230
liver	100%	2682.16	226 / 226	82%	6.73	331 / 406
adipose	100%	4418.10	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3240.99	1335 / 1335	0%	0	0 / 0
muscle	100%	3674.10	803 / 803	0%	0	0 / 0
spleen	100%	4289.02	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	6.01	1 / 1
heart	98%	2269.27	846 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	12.58	44 / 45
peripheral blood	95%	2426.27	879 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	93%	8.98	74 / 80
lymph node	0%	0	0 / 0	90%	9.88	26 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0