GSPT1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	26 studies	26% ± 9%	Explore
T cell	21 studies	23% ± 8%	Explore
fibroblast	19 studies	24% ± 8%	Explore
CD4-positive, alpha-beta T cell	18 studies	23% ± 8%	Explore
epithelial cell	15 studies	35% ± 20%	Explore
macrophage	14 studies	24% ± 8%	Explore
basal cell	14 studies	34% ± 15%	Explore
CD8-positive, alpha-beta T cell	14 studies	22% ± 7%	Explore
B cell	12 studies	19% ± 4%	Explore
smooth muscle cell	12 studies	20% ± 4%	Explore
regulatory T cell	12 studies	25% ± 8%	Explore
endothelial cell of lymphatic vessel	10 studies	22% ± 5%	Explore
type II pneumocyte	10 studies	37% ± 13%	Explore
natural killer cell	9 studies	22% ± 4%	Explore
erythrocyte	9 studies	37% ± 12%	Explore
club cell	9 studies	28% ± 13%	Explore
ciliated cell	9 studies	33% ± 14%	Explore
astrocyte	9 studies	28% ± 9%	Explore
adipocyte	9 studies	21% ± 6%	Explore
pericyte	9 studies	24% ± 6%	Explore
endothelial cell of vascular tree	9 studies	26% ± 5%	Explore
type I pneumocyte	8 studies	28% ± 8%	Explore
plasmablast	8 studies	36% ± 18%	Explore
glutamatergic neuron	8 studies	38% ± 23%	Explore
respiratory goblet cell	7 studies	29% ± 16%	Explore
secretory cell	7 studies	30% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	25% ± 9%	Explore
mucosal invariant T cell	7 studies	22% ± 4%	Explore
myeloid cell	7 studies	25% ± 9%	Explore
vein endothelial cell	7 studies	26% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	28% ± 12%	Explore
gamma-delta T cell	7 studies	36% ± 17%	Explore
oligodendrocyte	7 studies	24% ± 6%	Explore
monocyte	6 studies	20% ± 3%	Explore
non-classical monocyte	6 studies	25% ± 8%	Explore
conventional dendritic cell	6 studies	26% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	31% ± 15%	Explore
GABAergic neuron	6 studies	35% ± 18%	Explore
oligodendrocyte precursor cell	6 studies	30% ± 8%	Explore
abnormal cell	6 studies	26% ± 9%	Explore
mast cell	5 studies	20% ± 5%	Explore
leukocyte	5 studies	26% ± 5%	Explore
mononuclear phagocyte	5 studies	22% ± 6%	Explore
mature NK T cell	5 studies	27% ± 12%	Explore
neuron	5 studies	31% ± 11%	Explore
transit amplifying cell	5 studies	33% ± 25%	Explore
microglial cell	5 studies	23% ± 6%	Explore
myofibroblast cell	5 studies	21% ± 4%	Explore
T follicular helper cell	5 studies	23% ± 6%	Explore
goblet cell	5 studies	36% ± 16%	Explore
interneuron	5 studies	33% ± 20%	Explore
dendritic cell	4 studies	32% ± 13%	Explore
ionocyte	4 studies	26% ± 5%	Explore
classical monocyte	4 studies	23% ± 7%	Explore
naive B cell	4 studies	21% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	27% ± 7%	Explore
hematopoietic precursor cell	4 studies	24% ± 9%	Explore
erythroblast	4 studies	40% ± 16%	Explore
connective tissue cell	4 studies	23% ± 4%	Explore
innate lymphoid cell	4 studies	23% ± 8%	Explore
lymphocyte	4 studies	32% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	24% ± 5%	Explore
capillary endothelial cell	4 studies	22% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	32% ± 17%	Explore
endothelial cell of artery	4 studies	20% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	36% ± 13%	Explore
memory B cell	4 studies	22% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	24% ± 8%	Explore
plasma cell	3 studies	33% ± 16%	Explore
hillock cell	3 studies	22% ± 4%	Explore
squamous epithelial cell	3 studies	43% ± 21%	Explore
pancreatic A cell	3 studies	40% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	24% ± 4%	Explore
neural crest cell	3 studies	19% ± 4%	Explore
retinal pigment epithelial cell	3 studies	27% ± 10%	Explore
CD4-positive helper T cell	3 studies	37% ± 15%	Explore
muscle cell	3 studies	26% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	33% ± 8%	Explore
alveolar macrophage	3 studies	23% ± 8%	Explore
T-helper 17 cell	3 studies	24% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	25% ± 9%	Explore
brain	9 studies	33% ± 15%	Explore
peripheral blood	6 studies	25% ± 7%	Explore
intestine	5 studies	20% ± 6%	Explore
liver	5 studies	33% ± 16%	Explore
uterus	4 studies	27% ± 15%	Explore
prostate	4 studies	27% ± 9%	Explore
adipose	4 studies	17% ± 1%	Explore
pancreas	3 studies	38% ± 11%	Explore
eye	3 studies	27% ± 11%	Explore
breast	3 studies	28% ± 9%	Explore
bone marrow	3 studies	19% ± 3%	Explore
kidney	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	6924.92	459 / 459	100%	108.61	1118 / 1118
esophagus	100%	7302.66	1445 / 1445	100%	80.23	183 / 183
intestine	100%	7308.73	966 / 966	100%	78.28	527 / 527
lung	100%	7452.52	578 / 578	100%	70.33	1155 / 1155
ovary	100%	5427.33	180 / 180	100%	55.92	430 / 430
pancreas	100%	5110.81	328 / 328	100%	50.70	178 / 178
prostate	100%	7116.58	245 / 245	100%	82.07	502 / 502
stomach	100%	6459.41	359 / 359	100%	74.59	286 / 286
bladder	100%	7058.62	21 / 21	100%	66.30	503 / 504
uterus	100%	5451.73	170 / 170	100%	66.01	458 / 459
brain	100%	4260.01	2629 / 2642	100%	63.67	705 / 705
skin	100%	7929.04	1809 / 1809	99%	62.36	469 / 472
thymus	100%	6475.90	653 / 653	99%	52.74	601 / 605
kidney	100%	5617.84	89 / 89	99%	46.24	893 / 901
liver	100%	4136.88	226 / 226	96%	30.87	391 / 406
adrenal gland	100%	8957.99	258 / 258	93%	33.94	213 / 230
adipose	100%	7223.51	1204 / 1204	0%	0	0 / 0
blood vessel	100%	6030.81	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	57.32	29 / 29
muscle	100%	11959.01	803 / 803	0%	0	0 / 0
peripheral blood	100%	7183.97	929 / 929	0%	0	0 / 0
spleen	100%	6201.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	62.54	45 / 45
ureter	0%	0	0 / 0	100%	31.98	1 / 1
heart	96%	5205.41	829 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	34.90	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006412	Biological process	translation
GO_0006479	Biological process	protein methylation
GO_0000184	Biological process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0006415	Biological process	translational termination
GO_0006449	Biological process	regulation of translational termination
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0018444	Cellular component	translation release factor complex
GO_0022626	Cellular component	cytosolic ribosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005525	Molecular function	GTP binding
GO_0003924	Molecular function	GTPase activity
GO_0005515	Molecular function	protein binding
GO_0003747	Molecular function	translation release factor activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	GSPT1
Protein name	G1 to S phase transition 1 Eukaryotic peptide chain release factor GTP-binding subunit (ERF2) (Polypeptide release factor 3) (Translation release factor 3) Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (EC 3.6.5.-) (G1 to S phase transition protein 1 homolog)
Synonyms	ERF3A
Description	FUNCTION: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA . GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site . GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site . Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons . Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes . .
Accessions	ENST00000563468.5 [P15170-1] ENST00000562169.1 H3BMT9 H3BSV8 H3BR35 ENST00000420576.6 [P15170-1] ENST00000565267.5 ENST00000434724.7 [P15170-3] ENST00000439887.6 [P15170-2] P15170 ENST00000568849.5

GSPT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review