GRSF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043484Biological processregulation of RNA splicing
GO_0000962Biological processpositive regulation of mitochondrial RNA catabolic process
GO_0006397Biological processmRNA processing
GO_0009952Biological processanterior/posterior pattern specification
GO_0008033Biological processtRNA processing
GO_0016331Biological processmorphogenesis of embryonic epithelium
GO_0000957Biological processmitochondrial RNA catabolic process
GO_0035770Cellular componentribonucleoprotein granule
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005759Cellular componentmitochondrial matrix
GO_0042645Cellular componentmitochondrial nucleoid
GO_0005737Cellular componentcytoplasm
GO_0003729Molecular functionmRNA binding
GO_0002151Molecular functionG-quadruplex RNA binding
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameGRSF1
Protein nameG-rich RNA sequence binding factor 1
G-rich sequence factor 1 (GRSF-1)
Synonyms
DescriptionFUNCTION: Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences . Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules . Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome . G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA . .

AccessionsENST00000514161.5
ENST00000502323.5 [Q12849-5]
H0YAM1
Q12849
ENST00000499044.6
H0Y8R1
H0YAK1
ENST00000254799.11 [Q12849-1]
ENST00000506453.1