GLUD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	25 studies	24% ± 7%	Explore
macrophage	23 studies	22% ± 6%	Explore
astrocyte	21 studies	51% ± 21%	Explore
endothelial cell	17 studies	30% ± 11%	Explore
natural killer cell	16 studies	22% ± 6%	Explore
regulatory T cell	13 studies	23% ± 6%	Explore
classical monocyte	12 studies	23% ± 8%	Explore
pericyte	12 studies	21% ± 5%	Explore
basal cell	11 studies	32% ± 17%	Explore
CD4-positive, alpha-beta T cell	11 studies	19% ± 3%	Explore
conventional dendritic cell	10 studies	29% ± 14%	Explore
non-classical monocyte	10 studies	26% ± 11%	Explore
oligodendrocyte	10 studies	25% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	9 studies	22% ± 6%	Explore
capillary endothelial cell	9 studies	18% ± 3%	Explore
dendritic cell	9 studies	29% ± 15%	Explore
myeloid cell	9 studies	22% ± 6%	Explore
epithelial cell	9 studies	34% ± 14%	Explore
monocyte	9 studies	21% ± 5%	Explore
smooth muscle cell	8 studies	19% ± 3%	Explore
B cell	8 studies	21% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	26% ± 7%	Explore
CD8-positive, alpha-beta T cell	8 studies	20% ± 3%	Explore
myofibroblast cell	8 studies	20% ± 4%	Explore
oligodendrocyte precursor cell	8 studies	28% ± 9%	Explore
gamma-delta T cell	8 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	20% ± 5%	Explore
club cell	7 studies	25% ± 5%	Explore
mature NK T cell	7 studies	23% ± 10%	Explore
mucosal invariant T cell	7 studies	19% ± 1%	Explore
connective tissue cell	7 studies	23% ± 5%	Explore
secretory cell	6 studies	24% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	6 studies	18% ± 3%	Explore
epithelial cell of proximal tubule	6 studies	27% ± 3%	Explore
renal alpha-intercalated cell	6 studies	30% ± 8%	Explore
microglial cell	6 studies	22% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	20% ± 4%	Explore
T cell	6 studies	23% ± 7%	Explore
hematopoietic precursor cell	5 studies	21% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
neuron	5 studies	42% ± 20%	Explore
glutamatergic neuron	5 studies	45% ± 20%	Explore
abnormal cell	5 studies	31% ± 25%	Explore
retinal rod cell	5 studies	28% ± 8%	Explore
mononuclear phagocyte	5 studies	24% ± 10%	Explore
ciliated cell	5 studies	29% ± 9%	Explore
Mueller cell	5 studies	41% ± 13%	Explore
endothelial cell of vascular tree	5 studies	21% ± 5%	Explore
hepatocyte	5 studies	67% ± 20%	Explore
type I pneumocyte	5 studies	21% ± 5%	Explore
GABAergic neuron	5 studies	38% ± 16%	Explore
goblet cell	5 studies	31% ± 24%	Explore
endothelial cell of artery	5 studies	19% ± 2%	Explore
squamous epithelial cell	4 studies	31% ± 26%	Explore
kidney loop of Henle epithelial cell	4 studies	18% ± 1%	Explore
enterocyte	4 studies	18% ± 2%	Explore
retinal cone cell	4 studies	20% ± 2%	Explore
retinal pigment epithelial cell	4 studies	26% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	31% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	25% ± 6%	Explore
alveolar macrophage	4 studies	21% ± 6%	Explore
naive B cell	4 studies	18% ± 1%	Explore
vein endothelial cell	4 studies	17% ± 3%	Explore
interneuron	4 studies	31% ± 17%	Explore
ionocyte	3 studies	31% ± 2%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	17% ± 2%	Explore
glial cell	3 studies	29% ± 9%	Explore
precursor B cell	3 studies	18% ± 2%	Explore
tissue-resident macrophage	3 studies	18% ± 2%	Explore
endothelial cell of lymphatic vessel	3 studies	23% ± 3%	Explore
muscle cell	3 studies	32% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
ependymal cell	3 studies	45% ± 22%	Explore
leukocyte	3 studies	19% ± 3%	Explore
respiratory goblet cell	3 studies	30% ± 8%	Explore
T follicular helper cell	3 studies	20% ± 3%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 7%	Explore
keratinocyte	3 studies	19% ± 2%	Explore
plasmacytoid dendritic cell	3 studies	22% ± 2%	Explore
memory B cell	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	28% ± 14%	Explore
lung	9 studies	24% ± 5%	Explore
peripheral blood	9 studies	21% ± 6%	Explore
eye	7 studies	26% ± 4%	Explore
liver	6 studies	33% ± 21%	Explore
kidney	5 studies	21% ± 3%	Explore
skin	3 studies	20% ± 4%	Explore
adipose	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
kidney	100%	12422.16	89 / 89	100%	225.35	901 / 901
liver	100%	34201.24	226 / 226	100%	334.62	406 / 406
brain	100%	22050.24	2641 / 2642	100%	425.30	705 / 705
esophagus	100%	8190.64	1444 / 1445	100%	139.40	183 / 183
breast	100%	9741.85	459 / 459	100%	195.53	1115 / 1118
bladder	100%	8269.57	21 / 21	100%	126.75	502 / 504
prostate	100%	9984.48	244 / 245	100%	308.53	501 / 502
lung	100%	8184.77	577 / 578	99%	124.34	1148 / 1155
thymus	100%	7088.46	651 / 653	100%	128.36	602 / 605
intestine	100%	7954.73	966 / 966	99%	121.60	521 / 527
uterus	100%	6713.94	170 / 170	98%	108.47	452 / 459
ovary	100%	7722.03	180 / 180	98%	90.95	423 / 430
stomach	100%	5999.50	359 / 359	98%	110.89	279 / 286
adrenal gland	100%	11957.50	258 / 258	97%	109.14	224 / 230
pancreas	95%	4055.83	310 / 328	99%	123.71	176 / 178
skin	100%	10979.02	1809 / 1809	93%	89.48	439 / 472
adipose	100%	8755.68	1204 / 1204	0%	0	0 / 0
spleen	100%	5844.42	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	77.19	1 / 1
blood vessel	100%	8774.65	1334 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	117.53	44 / 45
lymph node	0%	0	0 / 0	97%	93.94	28 / 29
muscle	96%	3732.79	770 / 803	0%	0	0 / 0
heart	93%	5069.14	801 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	78%	63.51	62 / 80
peripheral blood	68%	3585.81	628 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006541	Biological process	glutamine metabolic process
GO_0006537	Biological process	glutamate biosynthetic process
GO_0032024	Biological process	positive regulation of insulin secretion
GO_0006538	Biological process	glutamate catabolic process
GO_0021762	Biological process	substantia nigra development
GO_0072350	Biological process	tricarboxylic acid metabolic process
GO_0005739	Cellular component	mitochondrion
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0042803	Molecular function	protein homodimerization activity
GO_0043531	Molecular function	ADP binding
GO_0070728	Molecular function	L-leucine binding
GO_0005525	Molecular function	GTP binding
GO_0070403	Molecular function	NAD+ binding
GO_0004354	Molecular function	glutamate dehydrogenase (NADP+) activity
GO_0005524	Molecular function	ATP binding
GO_0004352	Molecular function	glutamate dehydrogenase (NAD+) activity
GO_0005515	Molecular function	protein binding
GO_0004353	Molecular function	glutamate dehydrogenase [NAD(P)+] activity

IV. Literature review

[source]

Gene name	GLUD1
Protein name	Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) Glutamate dehydrogenase Glutamate dehydrogenase 1 Glutamate dehydrogenase (NAD(P)+) (EC 1.4.1.3) Glutamate dehydrogenase 1, mitochondrial (EC 1.4.1.3)
Synonyms	hCG_1993805 GLUD
Description	FUNCTION: Mitochondrial glutamate dehydrogenase that catalyzes the conversion of L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle . Plays a role in insulin homeostasis . May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). .
Accessions	A0A804HJH3 ENST00000684434.1 A0A804HJZ0 ENST00000683783.1 [P00367-2] ENST00000277865.5 [P00367-1] ENST00000683256.1 [P00367-2] A0A804HLC0 Q9UQV0 A0A804HHS2 E9KL48 ENST00000682507.1 [P00367-2] ENST00000684338.1 ENST00000682833.1 ENST00000684201.1 ENST00000683022.1 ENST00000682622.1 P00367 ENST00000681988.1 [P00367-2] Q14400 A0A804HIA0 ENST00000683269.1 [P00367-2] ENST00000684032.1 ENST00000682396.1 ENST00000684372.1 [P00367-2] A0A804HJD7 A0A804HHU3 A0A804HKE0 ENST00000684546.1 [P00367-2]

GLUD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review