EIF4E2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0006413Biological processtranslational initiation
GO_0072344Biological processrescue of stalled ribosome
GO_0045947Biological processnegative regulation of translational initiation
GO_0017148Biological processnegative regulation of translation
GO_0035278Biological processmiRNA-mediated gene silencing by inhibition of translation
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0016281Cellular componenteukaryotic translation initiation factor 4F complex
GO_0005737Cellular componentcytoplasm
GO_0003743Molecular functiontranslation initiation factor activity
GO_0000339Molecular functionRNA cap binding
GO_0008135Molecular functiontranslation factor activity, RNA binding
GO_0098808Molecular functionmRNA cap binding
GO_0000340Molecular functionRNA 7-methylguanosine cap binding
GO_0005515Molecular functionprotein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameEIF4E2
Protein nameEukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)
Eukaryotic translation initiation factor 4E family member 2 (cDNA FLJ59146, moderately similar to Eukaryotic translation initiation factor 4E type 3)
Eukaryotic translation initiation factor 4E member 2, isoform CRA_c (cDNA FLJ12456 fis, clone NT2RM1000661, highly similar to Eukaryotic translation initiation factor 4E type 3)
Eukaryotic translation initiation factor 4E family member 2
Synonymstmp_locus_9
hCG_33450
EIF4EL3
DescriptionFUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation . In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity). In P-bodies, component of a complex that promotes miRNA-mediated translational repression . Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism . .; FUNCTION: Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation . In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist . .; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, the interaction with non-structural protein 2 (nsp2) with GIGYF2 enhances GIGYF2 binding to EIF4E2 and increases repression of translation initiation of genes involved in antiviral innate immune response such as IFNB1. .

AccessionsENST00000258416.8 [O60573-1]
O60573
Q53RG0
B8ZZ50
ENST00000690794.1
H7BZH2
B9A044
A0A8I5KSA5
B8ZZL3
ENST00000409495.6
ENST00000454501.1
A0A8I5KT16
ENST00000409167.8
ENST00000409322.5
ENST00000444113.1
B9A023
C9JEL3
ENST00000409394.5
ENST00000409514.5
B4E1E4
ENST00000409098.5 [O60573-2]
ENST00000687222.1