DNPH1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
regulatory T cell	19 studies	38% ± 14%	Explore
macrophage	17 studies	33% ± 13%	Explore
ciliated cell	16 studies	64% ± 14%	Explore
CD4-positive, alpha-beta T cell	15 studies	30% ± 12%	Explore
epithelial cell	14 studies	38% ± 20%	Explore
B cell	13 studies	21% ± 6%	Explore
plasma cell	11 studies	31% ± 10%	Explore
basal cell	10 studies	28% ± 18%	Explore
conventional dendritic cell	10 studies	27% ± 14%	Explore
CD8-positive, alpha-beta T cell	10 studies	34% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	20% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	27% ± 12%	Explore
fibroblast	8 studies	27% ± 9%	Explore
memory B cell	8 studies	21% ± 6%	Explore
smooth muscle cell	8 studies	20% ± 4%	Explore
T cell	7 studies	25% ± 7%	Explore
progenitor cell	7 studies	37% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	35% ± 10%	Explore
non-classical monocyte	6 studies	33% ± 6%	Explore
epithelial cell of proximal tubule	6 studies	60% ± 10%	Explore
connective tissue cell	6 studies	21% ± 5%	Explore
enterocyte	6 studies	48% ± 17%	Explore
goblet cell	6 studies	32% ± 10%	Explore
intestinal crypt stem cell	6 studies	35% ± 14%	Explore
transit amplifying cell	6 studies	38% ± 16%	Explore
abnormal cell	6 studies	29% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	28% ± 11%	Explore
classical monocyte	5 studies	24% ± 11%	Explore
kidney loop of Henle epithelial cell	5 studies	35% ± 5%	Explore
natural killer cell	5 studies	24% ± 6%	Explore
naive B cell	5 studies	25% ± 5%	Explore
erythroblast	5 studies	32% ± 12%	Explore
myofibroblast cell	5 studies	19% ± 2%	Explore
T follicular helper cell	5 studies	26% ± 8%	Explore
hematopoietic precursor cell	4 studies	30% ± 8%	Explore
deuterosomal cell	4 studies	33% ± 7%	Explore
exhausted T cell	4 studies	34% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	38% ± 10%	Explore
enteroendocrine cell	4 studies	32% ± 11%	Explore
monocyte	4 studies	24% ± 4%	Explore
hematopoietic stem cell	4 studies	22% ± 4%	Explore
myeloid cell	4 studies	38% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	33% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	26% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	31% ± 9%	Explore
plasmablast	3 studies	46% ± 17%	Explore
pancreatic A cell	3 studies	25% ± 8%	Explore
leukocyte	3 studies	28% ± 7%	Explore
neural crest cell	3 studies	16% ± 0%	Explore
gamma-delta T cell	3 studies	32% ± 14%	Explore
common myeloid progenitor	3 studies	33% ± 9%	Explore
type I pneumocyte	3 studies	27% ± 8%	Explore
type II pneumocyte	3 studies	34% ± 11%	Explore
endothelial cell	3 studies	25% ± 10%	Explore
intermediate monocyte	3 studies	27% ± 9%	Explore
mesothelial cell	3 studies	29% ± 18%	Explore
dendritic cell	3 studies	46% ± 9%	Explore
erythrocyte	3 studies	38% ± 15%	Explore
secretory cell	3 studies	37% ± 20%	Explore
mononuclear phagocyte	3 studies	35% ± 25%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	39% ± 6%	Explore
progenitor cell of mammary luminal epithelium	3 studies	17% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
intestine	9 studies	28% ± 13%	Explore
lung	8 studies	31% ± 15%	Explore
kidney	7 studies	28% ± 9%	Explore
peripheral blood	5 studies	20% ± 6%	Explore
lymph node	3 studies	23% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	1691.19	226 / 226	100%	162.61	406 / 406
esophagus	100%	1134.17	1444 / 1445	100%	75.83	183 / 183
brain	100%	1413.39	2632 / 2642	100%	96.06	705 / 705
prostate	100%	1067.81	245 / 245	99%	120.26	499 / 502
uterus	100%	1185.74	170 / 170	99%	101.33	456 / 459
stomach	100%	1072.11	359 / 359	99%	141.40	284 / 286
intestine	100%	1530.11	966 / 966	99%	146.76	523 / 527
skin	100%	1079.55	1806 / 1809	99%	107.65	466 / 472
thymus	100%	933.42	652 / 653	99%	61.51	597 / 605
kidney	100%	3463.01	89 / 89	98%	120.92	887 / 901
bladder	100%	946.76	21 / 21	98%	105.62	495 / 504
ovary	98%	946.67	177 / 180	100%	150.20	429 / 430
pancreas	100%	1291.61	328 / 328	98%	84.62	174 / 178
lung	98%	818.62	569 / 578	98%	80.41	1131 / 1155
adrenal gland	100%	2391.51	258 / 258	95%	61.64	218 / 230
breast	100%	923.06	459 / 459	94%	66.91	1046 / 1118
eye	0%	0	0 / 0	100%	168.20	80 / 80
lymph node	0%	0	0 / 0	100%	192.32	29 / 29
spleen	100%	1470.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	75.68	45 / 45
ureter	0%	0	0 / 0	100%	118.63	1 / 1
adipose	99%	885.29	1196 / 1204	0%	0	0 / 0
muscle	99%	875.09	794 / 803	0%	0	0 / 0
heart	94%	705.70	813 / 861	0%	0	0 / 0
blood vessel	93%	515.45	1242 / 1335	0%	0	0 / 0
peripheral blood	64%	716.67	597 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006195	Biological process	purine nucleotide catabolic process
GO_0043174	Biological process	nucleoside salvage
GO_0030307	Biological process	positive regulation of cell growth
GO_0030855	Biological process	epithelial cell differentiation
GO_0009159	Biological process	deoxyribonucleoside monophosphate catabolic process
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0070694	Molecular function	deoxyribonucleoside 5'-monophosphate N-glycosidase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DNPH1
Protein name	5-hydroxymethyl-dUMP N-hydrolase (EC 3.2.2.-) (2'-deoxynucleoside 5'-phosphate N-hydrolase 1) (c-Myc-responsive protein RCL) 5-hydroxymethyl-dUMP N-hydrolase (2'-deoxynucleoside 5'-phosphate N-hydrolase 1)
Synonyms	RCL C6orf108
Description	FUNCTION: Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) . Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration . .
Accessions	H0Y8X4 O43598 ENST00000509253.5 ENST00000393987.2 [O43598-2] ENST00000230431.11 [O43598-1]

DNPH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review