DNAJB9 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
plasma cell	20 studies	48% ± 22%	Explore
fibroblast	16 studies	31% ± 16%	Explore
CD4-positive, alpha-beta T cell	15 studies	20% ± 5%	Explore
plasmacytoid dendritic cell	14 studies	29% ± 11%	Explore
pericyte	12 studies	28% ± 11%	Explore
T cell	11 studies	23% ± 6%	Explore
mast cell	11 studies	21% ± 5%	Explore
natural killer cell	11 studies	19% ± 3%	Explore
endothelial cell	10 studies	26% ± 6%	Explore
smooth muscle cell	10 studies	28% ± 8%	Explore
B cell	9 studies	21% ± 9%	Explore
CD8-positive, alpha-beta T cell	8 studies	19% ± 4%	Explore
IgG plasma cell	8 studies	37% ± 17%	Explore
IgA plasma cell	7 studies	41% ± 17%	Explore
connective tissue cell	7 studies	30% ± 19%	Explore
naive B cell	6 studies	18% ± 3%	Explore
mucosal invariant T cell	6 studies	22% ± 5%	Explore
endothelial cell of vascular tree	6 studies	22% ± 6%	Explore
epithelial cell	6 studies	37% ± 14%	Explore
basal cell	6 studies	19% ± 3%	Explore
regulatory T cell	6 studies	21% ± 4%	Explore
conventional dendritic cell	5 studies	22% ± 4%	Explore
epithelial cell of proximal tubule	5 studies	21% ± 3%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	24% ± 6%	Explore
leukocyte	5 studies	24% ± 5%	Explore
gamma-delta T cell	5 studies	22% ± 5%	Explore
pancreatic A cell	4 studies	26% ± 5%	Explore
type B pancreatic cell	4 studies	57% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
mature NK T cell	4 studies	22% ± 5%	Explore
abnormal cell	4 studies	28% ± 12%	Explore
macrophage	4 studies	18% ± 2%	Explore
innate lymphoid cell	4 studies	20% ± 3%	Explore
plasmablast	4 studies	38% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	35% ± 7%	Explore
goblet cell	4 studies	17% ± 2%	Explore
T follicular helper cell	4 studies	28% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	24% ± 7%	Explore
pancreatic D cell	3 studies	45% ± 10%	Explore
mononuclear phagocyte	3 studies	28% ± 4%	Explore
retinal ganglion cell	3 studies	57% ± 26%	Explore
myeloid cell	3 studies	26% ± 8%	Explore
type II pneumocyte	3 studies	28% ± 12%	Explore
Mueller cell	3 studies	28% ± 5%	Explore
CD4-positive helper T cell	3 studies	21% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	24% ± 6%	Explore
dendritic cell	3 studies	26% ± 7%	Explore
granulocyte	3 studies	22% ± 5%	Explore
IgM plasma cell	3 studies	33% ± 14%	Explore
GABAergic neuron	3 studies	19% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	21% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	5 studies	19% ± 4%	Explore
intestine	5 studies	23% ± 7%	Explore
uterus	5 studies	20% ± 5%	Explore
pancreas	4 studies	36% ± 12%	Explore
eye	4 studies	28% ± 9%	Explore
breast	4 studies	20% ± 4%	Explore
kidney	3 studies	22% ± 6%	Explore
peripheral blood	3 studies	16% ± 1%	Explore
lymph node	3 studies	21% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	5785.09	226 / 226	100%	86.90	405 / 406
breast	100%	2011.39	459 / 459	99%	58.03	1109 / 1118
kidney	100%	2543.71	89 / 89	99%	111.90	893 / 901
lung	100%	2821.19	577 / 578	99%	64.40	1146 / 1155
pancreas	100%	4978.52	328 / 328	99%	49.50	176 / 178
adrenal gland	100%	3522.61	258 / 258	99%	155.04	227 / 230
esophagus	100%	1321.44	1441 / 1445	99%	31.51	181 / 183
brain	99%	1776.74	2615 / 2642	100%	70.52	702 / 705
thymus	100%	2613.18	653 / 653	98%	78.95	595 / 605
prostate	99%	1935.36	243 / 245	99%	75.35	497 / 502
ovary	100%	2459.68	180 / 180	98%	32.82	422 / 430
stomach	100%	1738.17	359 / 359	98%	36.30	279 / 286
uterus	100%	2055.82	170 / 170	97%	36.04	443 / 459
intestine	100%	1564.39	963 / 966	97%	40.81	510 / 527
bladder	100%	1920.43	21 / 21	92%	35.00	466 / 504
skin	99%	1273.35	1782 / 1809	94%	51.75	442 / 472
muscle	100%	2565.20	803 / 803	0%	0	0 / 0
spleen	100%	1788.47	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.57	45 / 45
adipose	100%	2204.51	1203 / 1204	0%	0	0 / 0
blood vessel	100%	2574.85	1332 / 1335	0%	0	0 / 0
heart	96%	2825.38	827 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	28.81	26 / 29
peripheral blood	77%	1013.47	719 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	60%	15.70	48 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1903895	Biological process	negative regulation of IRE1-mediated unfolded protein response
GO_0006986	Biological process	response to unfolded protein
GO_0002639	Biological process	positive regulation of immunoglobulin production
GO_0036503	Biological process	ERAD pathway
GO_0030183	Biological process	B cell differentiation
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0005730	Cellular component	nucleolus
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005737	Cellular component	cytoplasm
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0030544	Molecular function	Hsp70 protein binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0051787	Molecular function	misfolded protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DNAJB9
Protein name	DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4) (ER-resident protein ERdj4) (ERdj4) (Microvascular endothelial differentiation gene 1 protein) (Mdg-1) DnaJ homolog subfamily B member 9 (Endoplasmic reticulum DNA J domain-containing protein 4)
Synonyms	UNQ743/PRO1471 MDG1 tcag7.15 hCG_17113 MST049
Description	FUNCTION: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins . In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). .
Accessions	ENST00000249356.4 Q9UBS3 Q6FIF1

DNAJB9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review