DENR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	19 studies	20% ± 4%	Explore
B cell	15 studies	24% ± 8%	Explore
CD8-positive, alpha-beta T cell	15 studies	21% ± 6%	Explore
regulatory T cell	15 studies	19% ± 4%	Explore
naive B cell	14 studies	20% ± 4%	Explore
CD4-positive, alpha-beta T cell	14 studies	22% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	20% ± 5%	Explore
endothelial cell	12 studies	26% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	20% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	20% ± 3%	Explore
memory B cell	10 studies	20% ± 2%	Explore
plasmacytoid dendritic cell	10 studies	22% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	21% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	20% ± 5%	Explore
T cell	8 studies	20% ± 6%	Explore
mucosal invariant T cell	8 studies	18% ± 3%	Explore
gamma-delta T cell	8 studies	24% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	21% ± 4%	Explore
basal cell	7 studies	32% ± 13%	Explore
ciliated cell	7 studies	32% ± 14%	Explore
myofibroblast cell	7 studies	20% ± 2%	Explore
fibroblast	7 studies	24% ± 6%	Explore
mature NK T cell	6 studies	18% ± 2%	Explore
abnormal cell	6 studies	28% ± 7%	Explore
pericyte	6 studies	21% ± 5%	Explore
smooth muscle cell	6 studies	18% ± 2%	Explore
microglial cell	6 studies	21% ± 6%	Explore
hematopoietic stem cell	6 studies	23% ± 5%	Explore
epithelial cell	6 studies	42% ± 18%	Explore
macrophage	6 studies	23% ± 7%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 10%	Explore
hematopoietic precursor cell	5 studies	29% ± 13%	Explore
classical monocyte	5 studies	23% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	19% ± 2%	Explore
non-classical monocyte	5 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
connective tissue cell	5 studies	24% ± 5%	Explore
neuron	5 studies	30% ± 15%	Explore
precursor B cell	5 studies	29% ± 7%	Explore
pro-B cell	5 studies	32% ± 8%	Explore
astrocyte	5 studies	26% ± 8%	Explore
leukocyte	4 studies	20% ± 4%	Explore
lymphocyte	4 studies	22% ± 8%	Explore
myeloid cell	4 studies	26% ± 8%	Explore
immature B cell	4 studies	27% ± 4%	Explore
T follicular helper cell	4 studies	19% ± 2%	Explore
GABAergic neuron	4 studies	39% ± 14%	Explore
glutamatergic neuron	4 studies	50% ± 17%	Explore
goblet cell	4 studies	26% ± 8%	Explore
interneuron	4 studies	33% ± 19%	Explore
oligodendrocyte	4 studies	20% ± 3%	Explore
plasmablast	3 studies	50% ± 1%	Explore
secretory cell	3 studies	28% ± 15%	Explore
pancreatic A cell	3 studies	34% ± 12%	Explore
conventional dendritic cell	3 studies	38% ± 14%	Explore
progenitor cell	3 studies	16% ± 1%	Explore
neural crest cell	3 studies	16% ± 1%	Explore
club cell	3 studies	20% ± 2%	Explore
endothelial cell of lymphatic vessel	3 studies	19% ± 5%	Explore
germinal center B cell	3 studies	20% ± 2%	Explore
exhausted T cell	3 studies	17% ± 1%	Explore
dendritic cell	3 studies	35% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	36% ± 18%	Explore
enteroendocrine cell	3 studies	27% ± 13%	Explore
intestinal crypt stem cell	3 studies	19% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 10%	Explore
transit amplifying cell	3 studies	31% ± 16%	Explore
innate lymphoid cell	3 studies	19% ± 1%	Explore
double negative thymocyte	3 studies	30% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	12 studies	22% ± 8%	Explore
lung	7 studies	28% ± 10%	Explore
brain	6 studies	34% ± 14%	Explore
bone marrow	4 studies	19% ± 3%	Explore
pancreas	3 studies	33% ± 13%	Explore
kidney	3 studies	17% ± 2%	Explore
eye	3 studies	20% ± 1%	Explore
intestine	3 studies	25% ± 11%	Explore
lymph node	3 studies	18% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	2911.24	21 / 21	100%	79.28	504 / 504
breast	100%	2817.32	459 / 459	100%	98.50	1118 / 1118
esophagus	100%	2842.01	1445 / 1445	100%	81.00	183 / 183
ovary	100%	2183.72	180 / 180	100%	71.17	430 / 430
prostate	100%	3178.57	245 / 245	100%	82.17	502 / 502
stomach	100%	1981.64	359 / 359	100%	67.20	286 / 286
uterus	100%	2536.48	170 / 170	100%	87.84	459 / 459
lung	100%	2109.64	577 / 578	100%	79.91	1155 / 1155
pancreas	100%	1534.40	327 / 328	100%	57.89	178 / 178
brain	100%	2150.07	2633 / 2642	100%	58.61	705 / 705
thymus	100%	2703.05	653 / 653	100%	67.25	602 / 605
intestine	100%	2816.66	966 / 966	99%	70.39	523 / 527
kidney	100%	2718.11	89 / 89	99%	51.80	893 / 901
liver	100%	1645.96	226 / 226	99%	38.72	401 / 406
skin	100%	3570.63	1809 / 1809	98%	68.05	464 / 472
adrenal gland	100%	2750.45	258 / 258	98%	46.91	226 / 230
adipose	100%	2641.38	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2620.53	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	78.46	29 / 29
muscle	100%	2854.74	803 / 803	0%	0	0 / 0
spleen	100%	3054.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	80.81	45 / 45
ureter	0%	0	0 / 0	100%	42.21	1 / 1
heart	97%	1586.32	832 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	91%	33.65	73 / 80
peripheral blood	81%	1992.83	749 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0001731	Biological process	formation of translation preinitiation complex
GO_0075522	Biological process	IRES-dependent viral translational initiation
GO_0032790	Biological process	ribosome disassembly
GO_0002188	Biological process	translation reinitiation
GO_0005575	Cellular component	cellular_component
GO_0003743	Molecular function	translation initiation factor activity
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	DENR
Protein name	Density-regulated protein Density-regulated protein (DRP) (Protein DRP1) (Smooth muscle cell-associated protein 3) (SMAP-3) Alternative protein DENR
Synonyms	DRP1 H14
Description	FUNCTION: May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. .
Accessions	ENST00000455982.2 ENST00000280557.11 F8VVL1 L8E7I3 O43583

DENR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review