DCTN2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
smooth muscle cell	22 studies	30% ± 12%	Explore
endothelial cell	22 studies	26% ± 11%	Explore
fibroblast	22 studies	28% ± 11%	Explore
pericyte	20 studies	30% ± 11%	Explore
natural killer cell	17 studies	20% ± 5%	Explore
CD8-positive, alpha-beta T cell	14 studies	22% ± 5%	Explore
myofibroblast cell	12 studies	32% ± 10%	Explore
epithelial cell	12 studies	33% ± 17%	Explore
endothelial cell of lymphatic vessel	11 studies	28% ± 10%	Explore
basal cell	11 studies	26% ± 13%	Explore
B cell	11 studies	20% ± 5%	Explore
CD4-positive, alpha-beta T cell	11 studies	22% ± 4%	Explore
connective tissue cell	11 studies	34% ± 10%	Explore
regulatory T cell	10 studies	25% ± 6%	Explore
classical monocyte	9 studies	24% ± 10%	Explore
capillary endothelial cell	9 studies	21% ± 9%	Explore
gamma-delta T cell	9 studies	22% ± 11%	Explore
non-classical monocyte	8 studies	25% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 5%	Explore
conventional dendritic cell	8 studies	27% ± 14%	Explore
abnormal cell	8 studies	23% ± 6%	Explore
macrophage	8 studies	20% ± 5%	Explore
astrocyte	8 studies	23% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	19% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	20% ± 4%	Explore
T cell	7 studies	20% ± 2%	Explore
neuron	7 studies	48% ± 24%	Explore
memory B cell	7 studies	18% ± 2%	Explore
endothelial cell of vascular tree	7 studies	20% ± 3%	Explore
plasmacytoid dendritic cell	7 studies	28% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	22% ± 6%	Explore
mature NK T cell	6 studies	18% ± 2%	Explore
vein endothelial cell	6 studies	23% ± 8%	Explore
ciliated cell	6 studies	31% ± 9%	Explore
oligodendrocyte precursor cell	6 studies	28% ± 5%	Explore
plasma cell	5 studies	29% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	22% ± 2%	Explore
endothelial cell of artery	5 studies	20% ± 4%	Explore
mesothelial cell	5 studies	32% ± 17%	Explore
hematopoietic stem cell	5 studies	25% ± 8%	Explore
glutamatergic neuron	5 studies	42% ± 18%	Explore
oligodendrocyte	5 studies	22% ± 5%	Explore
plasmablast	4 studies	47% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	27% ± 11%	Explore
pancreatic A cell	4 studies	43% ± 15%	Explore
exhausted T cell	4 studies	27% ± 6%	Explore
retinal ganglion cell	4 studies	80% ± 20%	Explore
platelet	4 studies	23% ± 6%	Explore
type I pneumocyte	4 studies	27% ± 7%	Explore
amacrine cell	4 studies	33% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	28% ± 3%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	29% ± 3%	Explore
GABAergic neuron	4 studies	39% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	24% ± 6%	Explore
enteroendocrine cell	4 studies	30% ± 17%	Explore
goblet cell	4 studies	24% ± 9%	Explore
interneuron	4 studies	31% ± 14%	Explore
naive B cell	4 studies	18% ± 3%	Explore
mucosal invariant T cell	4 studies	20% ± 3%	Explore
hematopoietic precursor cell	3 studies	39% ± 11%	Explore
secretory cell	3 studies	29% ± 10%	Explore
type B pancreatic cell	3 studies	46% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	19% ± 1%	Explore
neural crest cell	3 studies	29% ± 6%	Explore
retinal bipolar neuron	3 studies	31% ± 11%	Explore
lymphocyte	3 studies	23% ± 6%	Explore
retina horizontal cell	3 studies	39% ± 15%	Explore
retinal cone cell	3 studies	31% ± 12%	Explore
retinal rod cell	3 studies	23% ± 6%	Explore
monocyte	3 studies	19% ± 4%	Explore
Mueller cell	3 studies	27% ± 4%	Explore
dendritic cell	3 studies	43% ± 16%	Explore
pancreatic ductal cell	3 studies	45% ± 17%	Explore
megakaryocyte	3 studies	36% ± 3%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	38% ± 25%	Explore
double negative thymocyte	3 studies	29% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	22% ± 7%	Explore
brain	8 studies	30% ± 12%	Explore
lung	8 studies	29% ± 10%	Explore
intestine	6 studies	26% ± 12%	Explore
eye	6 studies	26% ± 10%	Explore
kidney	4 studies	21% ± 3%	Explore
lymph node	4 studies	22% ± 6%	Explore
pancreas	3 studies	49% ± 3%	Explore
bone marrow	3 studies	16% ± 1%	Explore
liver	3 studies	27% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9098.50	1445 / 1445	100%	29.22	183 / 183
intestine	100%	8488.77	966 / 966	100%	34.42	527 / 527
kidney	100%	6892.72	89 / 89	100%	38.25	901 / 901
lung	100%	6816.48	578 / 578	100%	37.70	1155 / 1155
ovary	100%	6437.41	180 / 180	100%	33.65	430 / 430
pancreas	100%	6053.30	328 / 328	100%	36.77	178 / 178
prostate	100%	6268.56	245 / 245	100%	35.43	502 / 502
skin	100%	8584.19	1809 / 1809	100%	40.43	472 / 472
stomach	100%	6693.93	359 / 359	100%	29.48	286 / 286
uterus	100%	8599.68	170 / 170	100%	41.63	459 / 459
thymus	100%	6834.26	653 / 653	100%	38.21	604 / 605
brain	100%	7548.99	2637 / 2642	100%	70.24	705 / 705
bladder	100%	7121.43	21 / 21	100%	38.17	503 / 504
breast	100%	7143.02	459 / 459	100%	39.09	1115 / 1118
adrenal gland	100%	8346.14	258 / 258	100%	55.81	229 / 230
liver	96%	2457.85	217 / 226	100%	22.31	405 / 406
adipose	100%	7261.30	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8263.44	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	38.88	80 / 80
lymph node	0%	0	0 / 0	100%	41.49	29 / 29
muscle	100%	7372.79	803 / 803	0%	0	0 / 0
spleen	100%	5695.61	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	41.16	45 / 45
ureter	0%	0	0 / 0	100%	19.16	1 / 1
heart	99%	5821.06	850 / 861	0%	0	0 / 0
peripheral blood	98%	5025.09	907 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007052	Biological process	mitotic spindle organization
GO_0071539	Biological process	protein localization to centrosome
GO_0032402	Biological process	melanosome transport
GO_0007080	Biological process	mitotic metaphase chromosome alignment
GO_0005869	Cellular component	dynactin complex
GO_0005874	Cellular component	microtubule
GO_0016020	Cellular component	membrane
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0070062	Cellular component	extracellular exosome
GO_0030286	Cellular component	dynein complex
GO_0005829	Cellular component	cytosol
GO_0030426	Cellular component	growth cone
GO_0005737	Cellular component	cytoplasm
GO_0031982	Cellular component	vesicle
GO_0030507	Molecular function	spectrin binding
GO_0019901	Molecular function	protein kinase binding
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DCTN2
Protein name	Dynactin subunit 2 Dynactin subunit 2 (50 kDa dynein-associated polypeptide) (Dynactin complex 50 kDa subunit) (DCTN-50) (p50 dynamitin)
Synonyms	DCTN50 hCG_2016464
Description	FUNCTION: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). .
Accessions	ENST00000550086.5 ENST00000678247.1 A0A7I2V5R4 ENST00000549394.5 F8VX93 ENST00000548249.6 [Q13561-1] ENST00000550750.2 ENST00000546670.5 A0A7I2V4H4 ENST00000678653.1 ENST00000550201.5 ENST00000678521.1 ENST00000551611.6 A0A7I2V4Y9 Q13561 ENST00000550954.5 ENST00000434715.7 [Q13561-2] H0YI98 ENST00000543672.6 [Q13561-3] ENST00000678322.1 A0A7I2V2Z2 ENST00000678505.1 F8VRV7 ENST00000546758.5 A8K8J9 A0A7I2V390 H0YHL1 A0A384MDU9 F8W0U6 F8VW18 F8W1I6

DCTN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review