CYBC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	25 studies	27% ± 9%	Explore
natural killer cell	22 studies	23% ± 5%	Explore
CD8-positive, alpha-beta T cell	15 studies	23% ± 4%	Explore
regulatory T cell	14 studies	26% ± 6%	Explore
CD4-positive, alpha-beta T cell	13 studies	22% ± 5%	Explore
memory B cell	12 studies	25% ± 3%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	24% ± 7%	Explore
naive B cell	12 studies	24% ± 6%	Explore
macrophage	12 studies	21% ± 6%	Explore
non-classical monocyte	11 studies	28% ± 10%	Explore
classical monocyte	11 studies	26% ± 10%	Explore
T cell	10 studies	21% ± 3%	Explore
gamma-delta T cell	10 studies	24% ± 8%	Explore
monocyte	9 studies	20% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	24% ± 4%	Explore
conventional dendritic cell	9 studies	28% ± 16%	Explore
plasmacytoid dendritic cell	9 studies	27% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	21% ± 5%	Explore
mature NK T cell	8 studies	21% ± 5%	Explore
plasma cell	7 studies	35% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	24% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	20% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	22% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 3%	Explore
precursor B cell	5 studies	33% ± 8%	Explore
endothelial cell	5 studies	25% ± 6%	Explore
dendritic cell	5 studies	30% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	25% ± 5%	Explore
mucosal invariant T cell	5 studies	19% ± 3%	Explore
plasmablast	4 studies	52% ± 22%	Explore
exhausted T cell	4 studies	31% ± 7%	Explore
myeloid cell	4 studies	25% ± 6%	Explore
immature B cell	4 studies	29% ± 5%	Explore
abnormal cell	4 studies	24% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	27% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	25% ± 5%	Explore
T follicular helper cell	4 studies	22% ± 4%	Explore
microglial cell	4 studies	25% ± 5%	Explore
hematopoietic precursor cell	3 studies	27% ± 7%	Explore
epithelial cell	3 studies	31% ± 2%	Explore
pro-B cell	3 studies	33% ± 6%	Explore
fibroblast	3 studies	26% ± 7%	Explore
leukocyte	3 studies	23% ± 7%	Explore
ciliated cell	3 studies	18% ± 3%	Explore
T-helper 17 cell	3 studies	17% ± 1%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	20% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	26% ± 7%	Explore
lung	4 studies	20% ± 1%	Explore
brain	4 studies	20% ± 3%	Explore
bone marrow	3 studies	17% ± 2%	Explore
lymph node	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2908.11	1445 / 1445	100%	26.42	183 / 183
ovary	100%	3334.11	180 / 180	100%	32.73	430 / 430
prostate	100%	4906.02	245 / 245	100%	39.50	502 / 502
stomach	100%	2799.12	359 / 359	100%	27.23	286 / 286
uterus	100%	3504.16	170 / 170	100%	37.20	458 / 459
lung	100%	4600.02	577 / 578	100%	39.38	1153 / 1155
bladder	100%	3648.57	21 / 21	100%	39.14	502 / 504
brain	100%	2289.90	2631 / 2642	100%	36.44	705 / 705
breast	100%	3699.19	459 / 459	100%	38.56	1113 / 1118
skin	100%	2741.68	1808 / 1809	100%	35.09	470 / 472
liver	100%	3336.38	226 / 226	100%	24.48	404 / 406
thymus	100%	3430.54	653 / 653	100%	31.59	602 / 605
intestine	100%	3777.29	966 / 966	99%	27.11	524 / 527
pancreas	99%	2341.35	326 / 328	99%	32.34	177 / 178
adrenal gland	100%	3425.75	258 / 258	97%	15.85	223 / 230
kidney	100%	3514.93	89 / 89	97%	31.10	873 / 901
adipose	100%	3739.12	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	23.33	80 / 80
lymph node	0%	0	0 / 0	100%	108.79	29 / 29
peripheral blood	100%	17914.79	929 / 929	0%	0	0 / 0
spleen	100%	13978.94	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	31.48	45 / 45
ureter	0%	0	0 / 0	100%	16.01	1 / 1
blood vessel	100%	2908.50	1331 / 1335	0%	0	0 / 0
heart	98%	1645.44	844 / 861	0%	0	0 / 0
muscle	59%	601.10	475 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045728	Biological process	respiratory burst after phagocytosis
GO_0045087	Biological process	innate immune response
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CYBC1
Protein name	Cytochrome b-245 chaperone 1 Essential for reactive oxygen species protein Chromosome 17 open reading frame 62, isoform CRA_d (cDNA FLJ14837 fis, clone OVARC1001711, weakly similar to CORNIFIN B) (cDNA FLJ31780 fis, clone NT2RI2008221, weakly similar to CORNIFIN B) Chromosome 17 open reading frame 62, isoform CRA_b (Cytochrome b-245 chaperone 1) Chromosome 17 open reading frame 62, isoform CRA_e (Cytochrome b-245 chaperone 1) Cytochrome b-245 chaperone 1 (Essential for reactive oxygen species protein) (Eros)
Synonyms	EROS hCG_30383 C17orf62
Description	FUNCTION: Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer . Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity). .
Accessions	H0Y2X1 ENST00000577436.5 [Q9BQA9-2] ENST00000342572.12 J3QS53 ENST00000698819.1 [Q9BQA9-1] ENST00000585064.5 [Q9BQA9-1] ENST00000577732.5 [Q9BQA9-1] ENST00000698829.1 ENST00000577834.5 A0A8V8TP29 Q969P4 J3KSB6 ENST00000434650.6 [Q9BQA9-2] ENST00000581196.6 ENST00000579751.6 A0A8V8TNQ9 ENST00000306645.10 [Q9BQA9-1] J3QRZ2 J3QQQ4 ENST00000583617.5 ENST00000698824.1 ENST00000698822.1 A0A8V8TNR4 ENST00000698823.1 ENST00000578919.6 [Q9BQA9-1] ENST00000584024.5 ENST00000698828.1 ENST00000577471.5 ENST00000698821.1 J3KS78 J3KTF4 J3KTI1 ENST00000437807.6 [Q9BQA9-1] J3KSJ5 ENST00000582545.2 ENST00000582725.6 ENST00000698820.1 [Q9BQA9-2] J3QKS6 ENST00000698827.1 ENST00000584503.5 ENST00000698826.1 ENST00000698825.1 J3QRG5 Q9BQA9 A0A8V8TMR4 ENST00000584408.6 A0A8V8TMA2 ENST00000584891.5 A0A8V8TM96 J3QKZ6 ENST00000577888.5 ENST00000577696.6 [Q9BQA9-1] A0A8V8TMR8 ENST00000585115.2 [Q9BQA9-2] ENST00000585080.5 [Q9BQA9-1] ENST00000580560.5 ENST00000582438.2 ENST00000577696.5 ENST00000578913.5 A0A8V8TP26 J3QLB7 ENST00000698818.1 A0A0U1RQN8

CYBC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review