CSK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0034332Biological processadherens junction organization
GO_0042997Biological processnegative regulation of Golgi to plasma membrane protein transport
GO_0045779Biological processnegative regulation of bone resorption
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0060368Biological processregulation of Fc receptor mediated stimulatory signaling pathway
GO_0031295Biological processT cell costimulation
GO_0010989Biological processnegative regulation of low-density lipoprotein particle clearance
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0050852Biological processT cell receptor signaling pathway
GO_0002250Biological processadaptive immune response
GO_0050765Biological processnegative regulation of phagocytosis
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0048709Biological processoligodendrocyte differentiation
GO_0006468Biological processprotein phosphorylation
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005911Cellular componentcell-cell junction
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0070064Molecular functionproline-rich region binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0034236Molecular functionprotein kinase A catalytic subunit binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCSK
Protein nameTyrosine-protein kinase (EC 2.7.10.2)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
C-terminal Src kinase
SynonymshCG_40804
DescriptionFUNCTION: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. .

AccessionsENST00000567571.5
ENST00000439220.6
P41240
ENST00000567123.1
B2R6Q4
ENST00000569915.1
ENST00000220003.14
H3BU69
H3BUM9
ENST00000569462.5
B5BU52
H3BN15