COMMD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032434Biological processregulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006289Biological processnucleotide-excision repair
GO_1902306Biological processnegative regulation of sodium ion transmembrane transport
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0006893Biological processGolgi to plasma membrane transport
GO_2000009Biological processnegative regulation of protein localization to cell surface
GO_0048227Biological processplasma membrane to endosome transport
GO_0015031Biological processprotein transport
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0055070Biological processcopper ion homeostasis
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0042802Molecular functionidentical protein binding
GO_0019871Molecular functionsodium channel inhibitor activity
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0070300Molecular functionphosphatidic acid binding
GO_0005507Molecular functioncopper ion binding
GO_0005515Molecular functionprotein binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]
Gene nameCOMMD1
Protein nameCOMM domain-containing protein 1 (Protein Murr1)
Copper metabolism domain containing 1
SynonymsC2orf5
MURR1
DescriptionFUNCTION: Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2 . Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity . Involved in the regulation of membrane expression and ubiquitination of SLC12A2 . Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes . Promotes CFTR cell surface expression through regulation of its ubiquitination . Down-regulates SOD1 activity by interfering with its homodimerization . Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes . Can bind one copper ion per monomer . May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) . Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1 . Negatively regulates neuroblastoma G1/S phase cell cycle progression and cell proliferation by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a FAM107A- and actin-dependent manner . .

AccessionsQ8N668
ENST00000311832.6 [Q8N668-1]
ENST00000427417.1
H7C377
H7C169
ENST00000455659.1
ENST00000444166.1
H0Y7J4
ENST00000458337.5