CNOT6L | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	37 studies	30% ± 12%	Explore
endothelial cell	30 studies	32% ± 13%	Explore
T cell	29 studies	28% ± 12%	Explore
CD8-positive, alpha-beta T cell	28 studies	30% ± 10%	Explore
CD4-positive, alpha-beta T cell	23 studies	31% ± 12%	Explore
mature NK T cell	17 studies	29% ± 14%	Explore
regulatory T cell	17 studies	31% ± 12%	Explore
gamma-delta T cell	15 studies	32% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	32% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	32% ± 11%	Explore
mucosal invariant T cell	13 studies	29% ± 12%	Explore
B cell	11 studies	25% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	36% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	32% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	40% ± 19%	Explore
endothelial cell of artery	9 studies	24% ± 5%	Explore
naive B cell	8 studies	22% ± 4%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	29% ± 9%	Explore
glutamatergic neuron	8 studies	41% ± 25%	Explore
microglial cell	8 studies	28% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	28% ± 7%	Explore
leukocyte	7 studies	39% ± 16%	Explore
T follicular helper cell	7 studies	29% ± 10%	Explore
GABAergic neuron	7 studies	40% ± 20%	Explore
oligodendrocyte	7 studies	27% ± 8%	Explore
macrophage	7 studies	28% ± 9%	Explore
epithelial cell	6 studies	32% ± 12%	Explore
capillary endothelial cell	6 studies	24% ± 10%	Explore
astrocyte	6 studies	31% ± 14%	Explore
oligodendrocyte precursor cell	6 studies	30% ± 12%	Explore
non-classical monocyte	5 studies	26% ± 10%	Explore
basal cell	5 studies	26% ± 13%	Explore
innate lymphoid cell	5 studies	29% ± 14%	Explore
endothelial cell of vascular tree	5 studies	31% ± 22%	Explore
fibroblast	5 studies	22% ± 7%	Explore
interneuron	5 studies	42% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	30% ± 13%	Explore
neuron	4 studies	29% ± 10%	Explore
pericyte	4 studies	22% ± 5%	Explore
memory B cell	4 studies	20% ± 2%	Explore
plasmacytoid dendritic cell	4 studies	24% ± 9%	Explore
plasma cell	4 studies	26% ± 7%	Explore
lymphocyte	4 studies	52% ± 21%	Explore
retinal rod cell	4 studies	24% ± 6%	Explore
CD4-positive helper T cell	4 studies	43% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	39% ± 21%	Explore
dendritic cell	4 studies	28% ± 8%	Explore
monocyte	4 studies	20% ± 4%	Explore
endothelial cell of lymphatic vessel	4 studies	26% ± 7%	Explore
smooth muscle cell	4 studies	17% ± 1%	Explore
classical monocyte	3 studies	21% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	32% ± 10%	Explore
exhausted T cell	3 studies	33% ± 13%	Explore
GABAergic interneuron	3 studies	19% ± 1%	Explore
myeloid cell	3 studies	20% ± 2%	Explore
vein endothelial cell	3 studies	38% ± 20%	Explore
ciliated cell	3 studies	26% ± 5%	Explore
ON-bipolar cell	3 studies	19% ± 5%	Explore
rod bipolar cell	3 studies	21% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	24% ± 8%	Explore
goblet cell	3 studies	29% ± 16%	Explore
T-helper 17 cell	3 studies	29% ± 7%	Explore
granule cell	3 studies	20% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	36% ± 19%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	36% ± 5%	Explore
mural cell	3 studies	47% ± 23%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	10 studies	34% ± 19%	Explore
peripheral blood	9 studies	25% ± 8%	Explore
lung	7 studies	21% ± 3%	Explore
intestine	4 studies	19% ± 2%	Explore
eye	4 studies	25% ± 8%	Explore
kidney	4 studies	17% ± 1%	Explore
liver	4 studies	26% ± 6%	Explore
bone marrow	3 studies	19% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3592.43	459 / 459	100%	23.84	1118 / 1118
esophagus	100%	2322.00	1445 / 1445	100%	21.03	183 / 183
lung	100%	3643.48	578 / 578	100%	17.07	1155 / 1155
prostate	100%	2841.54	245 / 245	100%	21.70	502 / 502
thymus	100%	2695.50	653 / 653	100%	20.55	603 / 605
pancreas	100%	1652.55	328 / 328	99%	16.20	177 / 178
brain	99%	1664.81	2626 / 2642	100%	14.41	705 / 705
uterus	100%	2940.52	170 / 170	99%	14.34	456 / 459
kidney	100%	2197.61	89 / 89	99%	21.26	894 / 901
bladder	100%	2934.19	21 / 21	99%	14.39	500 / 504
ovary	100%	2786.73	180 / 180	99%	9.34	426 / 430
stomach	100%	1964.69	359 / 359	99%	16.82	282 / 286
intestine	100%	2774.98	966 / 966	98%	14.16	516 / 527
adrenal gland	100%	2236.34	258 / 258	98%	12.57	225 / 230
skin	100%	3244.70	1809 / 1809	94%	13.99	444 / 472
liver	100%	1263.23	226 / 226	93%	8.62	377 / 406
blood vessel	100%	2684.47	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	20.88	29 / 29
spleen	100%	4558.30	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	18.81	45 / 45
ureter	0%	0	0 / 0	100%	12.48	1 / 1
adipose	100%	3857.22	1203 / 1204	0%	0	0 / 0
muscle	100%	1638.04	800 / 803	0%	0	0 / 0
heart	99%	1450.37	853 / 861	0%	0	0 / 0
peripheral blood	96%	3219.74	896 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	81%	7.68	65 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000289	Biological process	nuclear-transcribed mRNA poly(A) tail shortening
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0010606	Biological process	positive regulation of cytoplasmic mRNA processing body assembly
GO_0006397	Biological process	mRNA processing
GO_0031047	Biological process	regulatory ncRNA-mediated gene silencing
GO_0006417	Biological process	regulation of translation
GO_0030014	Cellular component	CCR4-NOT complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0004535	Molecular function	poly(A)-specific ribonuclease activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	CNOT6L
Protein name	CCR4-NOT transcription complex subunit 6 like CCR4-NOT transcription complex subunit 6-like (EC 3.1.13.4) (Carbon catabolite repressor protein 4 homolog B) poly(A)-specific ribonuclease (EC 3.1.13.4)
Synonyms	CCR4B
Description	FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. .
Accessions	ENST00000515506.6 ENST00000504804.7 H0Y9Z5 ENST00000504123.7 [Q96LI5-1] D6RIW9 ENST00000649644.1 Q96LI5 H0Y9C1 ENST00000512485.6

CNOT6L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review