CLPP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051603Biological processproteolysis involved in protein catabolic process
GO_0006508Biological processproteolysis
GO_0035694Biological processmitochondrial protein catabolic process
GO_0033619Biological processmembrane protein proteolysis
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0009368Cellular componentendopeptidase Clp complex
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0051117Molecular functionATPase binding
GO_0008233Molecular functionpeptidase activity
GO_0004175Molecular functionendopeptidase activity
GO_0004252Molecular functionserine-type endopeptidase activity
GO_0004176Molecular functionATP-dependent peptidase activity
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding

IV. Literature review

[source]
Gene nameCLPP
Protein nameEndopeptidase Clp (EC 3.4.21.92)
ATP-dependent Clp protease proteolytic subunit, mitochondrial (EC 3.4.21.92) (Endopeptidase Clp)
ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92)
ATP-dependent Clp protease proteolytic subunit
Caseinolytic mitochondrial matrix peptidase proteolytic subunit
Synonyms
DescriptionFUNCTION: Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates . Cleaves PINK1 in the mitochondrion . .

AccessionsA0A2R8YEF5
ENST00000245816.11
ENST00000596605.2
ENST00000596149.5
M0QXE9
ENST00000646643.1
M0QYV5
M0R208
Q16740
ENST00000597326.6