CHCHD3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	26 studies	33% ± 15%	Explore
astrocyte	18 studies	34% ± 18%	Explore
pericyte	15 studies	23% ± 8%	Explore
smooth muscle cell	15 studies	23% ± 7%	Explore
fibroblast	15 studies	29% ± 9%	Explore
oligodendrocyte precursor cell	13 studies	41% ± 19%	Explore
glutamatergic neuron	12 studies	46% ± 26%	Explore
microglial cell	12 studies	34% ± 12%	Explore
macrophage	12 studies	32% ± 14%	Explore
GABAergic neuron	11 studies	43% ± 26%	Explore
B cell	11 studies	23% ± 8%	Explore
oligodendrocyte	11 studies	36% ± 11%	Explore
natural killer cell	10 studies	23% ± 5%	Explore
epithelial cell	9 studies	36% ± 15%	Explore
adipocyte	9 studies	48% ± 17%	Explore
myeloid cell	9 studies	25% ± 6%	Explore
CD4-positive, alpha-beta T cell	8 studies	20% ± 4%	Explore
T cell	8 studies	27% ± 17%	Explore
dendritic cell	8 studies	29% ± 11%	Explore
ciliated cell	8 studies	28% ± 8%	Explore
endothelial cell of lymphatic vessel	8 studies	35% ± 16%	Explore
plasmacytoid dendritic cell	8 studies	25% ± 7%	Explore
CD8-positive, alpha-beta T cell	7 studies	22% ± 4%	Explore
neuron	6 studies	44% ± 18%	Explore
interneuron	6 studies	51% ± 25%	Explore
myofibroblast cell	6 studies	25% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	18% ± 2%	Explore
retinal cone cell	6 studies	30% ± 10%	Explore
mast cell	6 studies	24% ± 7%	Explore
type I pneumocyte	6 studies	34% ± 12%	Explore
type II pneumocyte	6 studies	37% ± 14%	Explore
club cell	6 studies	28% ± 10%	Explore
basal cell	6 studies	37% ± 16%	Explore
connective tissue cell	5 studies	22% ± 5%	Explore
retinal ganglion cell	5 studies	28% ± 14%	Explore
lymphocyte	5 studies	25% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 2%	Explore
amacrine cell	5 studies	34% ± 13%	Explore
retina horizontal cell	5 studies	34% ± 8%	Explore
retinal rod cell	5 studies	26% ± 5%	Explore
cardiac muscle cell	5 studies	60% ± 10%	Explore
monocyte	5 studies	32% ± 15%	Explore
goblet cell	5 studies	29% ± 19%	Explore
hematopoietic precursor cell	4 studies	29% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	21% ± 3%	Explore
non-classical monocyte	4 studies	23% ± 6%	Explore
kidney loop of Henle epithelial cell	4 studies	25% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	28% ± 10%	Explore
granule cell	4 studies	35% ± 11%	Explore
plasma cell	4 studies	29% ± 8%	Explore
capillary endothelial cell	4 studies	23% ± 9%	Explore
retinal bipolar neuron	4 studies	25% ± 2%	Explore
retinal pigment epithelial cell	4 studies	28% ± 14%	Explore
mesothelial cell	4 studies	27% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	20% ± 4%	Explore
abnormal cell	4 studies	40% ± 20%	Explore
erythrocyte	4 studies	37% ± 17%	Explore
naive B cell	4 studies	19% ± 2%	Explore
memory B cell	4 studies	19% ± 4%	Explore
regulatory T cell	4 studies	20% ± 2%	Explore
conventional dendritic cell	3 studies	36% ± 11%	Explore
renal alpha-intercalated cell	3 studies	25% ± 10%	Explore
neural crest cell	3 studies	21% ± 4%	Explore
GABAergic interneuron	3 studies	41% ± 3%	Explore
glial cell	3 studies	30% ± 9%	Explore
progenitor cell	3 studies	26% ± 4%	Explore
erythroblast	3 studies	35% ± 18%	Explore
precursor B cell	3 studies	21% ± 3%	Explore
pro-B cell	3 studies	24% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
mononuclear phagocyte	3 studies	28% ± 2%	Explore
vein endothelial cell	3 studies	28% ± 15%	Explore
GABAergic amacrine cell	3 studies	33% ± 8%	Explore
OFF-bipolar cell	3 studies	26% ± 8%	Explore
glycinergic amacrine cell	3 studies	30% ± 2%	Explore
rod bipolar cell	3 studies	34% ± 15%	Explore
endothelial cell of vascular tree	3 studies	29% ± 16%	Explore
hepatocyte	3 studies	46% ± 21%	Explore
ependymal cell	3 studies	36% ± 17%	Explore
granulocyte monocyte progenitor cell	3 studies	30% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	41% ± 17%	Explore
intestinal crypt stem cell	3 studies	23% ± 2%	Explore
leukocyte	3 studies	28% ± 3%	Explore
alveolar macrophage	3 studies	41% ± 13%	Explore
transit amplifying cell	3 studies	44% ± 27%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	19% ± 2%	Explore
mucosal invariant T cell	3 studies	17% ± 2%	Explore
mature NK T cell	3 studies	27% ± 12%	Explore
mucus secreting cell	3 studies	26% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	41% ± 21%	Explore
lung	9 studies	27% ± 11%	Explore
eye	7 studies	29% ± 11%	Explore
peripheral blood	5 studies	19% ± 5%	Explore
heart	5 studies	34% ± 9%	Explore
liver	4 studies	43% ± 23%	Explore
adipose	4 studies	36% ± 22%	Explore
intestine	3 studies	22% ± 8%	Explore
kidney	3 studies	29% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	2458.73	459 / 459	100%	54.50	1118 / 1118
ovary	100%	1708.22	180 / 180	100%	60.30	430 / 430
stomach	100%	1826.52	359 / 359	100%	56.42	286 / 286
intestine	100%	2729.62	966 / 966	100%	65.54	526 / 527
lung	100%	2026.29	576 / 578	100%	45.32	1155 / 1155
uterus	100%	2048.85	170 / 170	100%	51.44	457 / 459
skin	100%	2077.29	1804 / 1809	100%	87.95	470 / 472
esophagus	99%	2123.96	1434 / 1445	100%	35.74	183 / 183
kidney	100%	2729.18	89 / 89	99%	55.11	894 / 901
prostate	100%	1520.88	244 / 245	100%	37.74	500 / 502
bladder	100%	2348.52	21 / 21	99%	49.41	498 / 504
thymus	100%	2014.48	652 / 653	99%	47.68	598 / 605
brain	97%	1255.42	2575 / 2642	100%	55.09	705 / 705
adrenal gland	100%	2315.50	258 / 258	95%	39.11	219 / 230
pancreas	96%	869.87	314 / 328	99%	39.20	176 / 178
liver	86%	916.93	195 / 226	97%	30.67	394 / 406
adipose	100%	2661.05	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	49.26	29 / 29
muscle	100%	8320.01	803 / 803	0%	0	0 / 0
spleen	100%	1424.73	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	40.72	45 / 45
ureter	0%	0	0 / 0	100%	17.31	1 / 1
blood vessel	100%	2298.91	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	59.57	79 / 80
heart	97%	4644.94	832 / 861	0%	0	0 / 0
peripheral blood	80%	1655.70	739 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007007	Biological process	inner mitochondrial membrane organization
GO_0008053	Biological process	mitochondrial fusion
GO_0042407	Biological process	cristae formation
GO_0001401	Cellular component	SAM complex
GO_0070062	Cellular component	extracellular exosome
GO_0044284	Cellular component	mitochondrial crista junction
GO_0061617	Cellular component	MICOS complex
GO_0140275	Cellular component	MIB complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005634	Cellular component	nucleus
GO_0019902	Molecular function	phosphatase binding
GO_0005515	Molecular function	protein binding
GO_0060090	Molecular function	molecular adaptor activity

IV. Literature review

[source]

Gene name	CHCHD3
Protein name	Coiled-coil-helix-coiled-coil-helix domain containing 3 MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3)
Synonyms	MIC19 hCG_2014841 tcag7.1158 MINOS3
Description	FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology . .
Accessions	ENST00000262570.10 C9JRZ6 A4D1N4 ENST00000481152.2 ENST00000448878.6 Q9NX63 F8WAR4 A0A286YEX5 ENST00000423635.5

CHCHD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review