CCNY | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	32 studies	48% ± 18%	Explore
astrocyte	17 studies	39% ± 19%	Explore
oligodendrocyte	16 studies	53% ± 19%	Explore
microglial cell	15 studies	52% ± 15%	Explore
classical monocyte	14 studies	27% ± 12%	Explore
glutamatergic neuron	13 studies	49% ± 26%	Explore
macrophage	13 studies	42% ± 20%	Explore
oligodendrocyte precursor cell	13 studies	44% ± 18%	Explore
fibroblast	13 studies	33% ± 10%	Explore
smooth muscle cell	12 studies	29% ± 10%	Explore
GABAergic neuron	11 studies	44% ± 22%	Explore
pericyte	11 studies	34% ± 13%	Explore
epithelial cell	10 studies	35% ± 15%	Explore
B cell	9 studies	26% ± 6%	Explore
adipocyte	9 studies	36% ± 10%	Explore
endothelial cell of artery	8 studies	26% ± 10%	Explore
myeloid cell	8 studies	36% ± 12%	Explore
ciliated cell	8 studies	28% ± 10%	Explore
capillary endothelial cell	8 studies	32% ± 17%	Explore
neuron	7 studies	46% ± 23%	Explore
basal cell	7 studies	33% ± 17%	Explore
dendritic cell	7 studies	40% ± 17%	Explore
monocyte	7 studies	37% ± 13%	Explore
interneuron	6 studies	54% ± 19%	Explore
club cell	6 studies	30% ± 11%	Explore
mast cell	6 studies	27% ± 8%	Explore
mesothelial cell	6 studies	37% ± 11%	Explore
vein endothelial cell	6 studies	35% ± 24%	Explore
T cell	6 studies	24% ± 7%	Explore
endothelial cell of lymphatic vessel	6 studies	41% ± 14%	Explore
type II pneumocyte	6 studies	30% ± 10%	Explore
type I pneumocyte	6 studies	47% ± 16%	Explore
CD4-positive, alpha-beta T cell	5 studies	25% ± 2%	Explore
amacrine cell	5 studies	25% ± 7%	Explore
retina horizontal cell	5 studies	24% ± 8%	Explore
cardiac muscle cell	5 studies	37% ± 11%	Explore
non-classical monocyte	4 studies	33% ± 12%	Explore
hepatocyte	4 studies	51% ± 29%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	24% ± 4%	Explore
glial cell	4 studies	29% ± 8%	Explore
granule cell	4 studies	36% ± 12%	Explore
retinal cone cell	4 studies	26% ± 8%	Explore
CD8-positive, alpha-beta T cell	4 studies	22% ± 4%	Explore
mononuclear phagocyte	4 studies	26% ± 9%	Explore
lymphocyte	4 studies	34% ± 13%	Explore
retinal rod cell	4 studies	40% ± 9%	Explore
natural killer cell	4 studies	29% ± 3%	Explore
cholangiocyte	3 studies	42% ± 14%	Explore
endothelial cell of sinusoid	3 studies	29% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	20% ± 3%	Explore
hematopoietic precursor cell	3 studies	35% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	23% ± 3%	Explore
glomerular endothelial cell	3 studies	18% ± 1%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	45% ± 5%	Explore
GABAergic interneuron	3 studies	39% ± 9%	Explore
progenitor cell	3 studies	36% ± 3%	Explore
megakaryocyte	3 studies	38% ± 24%	Explore
plasma cell	3 studies	27% ± 1%	Explore
platelet	3 studies	20% ± 3%	Explore
endocardial cell	3 studies	34% ± 11%	Explore
GABAergic amacrine cell	3 studies	25% ± 8%	Explore
Mueller cell	3 studies	32% ± 6%	Explore
glycinergic amacrine cell	3 studies	25% ± 4%	Explore
retinal ganglion cell	3 studies	26% ± 9%	Explore
endothelial cell of vascular tree	3 studies	59% ± 22%	Explore
retinal pigment epithelial cell	3 studies	34% ± 17%	Explore
ependymal cell	3 studies	48% ± 15%	Explore
hematopoietic stem cell	3 studies	35% ± 7%	Explore
myofibroblast cell	3 studies	33% ± 11%	Explore
alveolar macrophage	3 studies	45% ± 12%	Explore
respiratory goblet cell	3 studies	39% ± 11%	Explore
goblet cell	3 studies	32% ± 19%	Explore
transit amplifying cell	3 studies	40% ± 30%	Explore
mucus secreting cell	3 studies	32% ± 4%	Explore
enteroendocrine cell	3 studies	24% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	49% ± 21%	Explore
lung	8 studies	28% ± 10%	Explore
eye	5 studies	37% ± 13%	Explore
peripheral blood	4 studies	28% ± 8%	Explore
heart	4 studies	38% ± 5%	Explore
liver	4 studies	34% ± 22%	Explore
intestine	3 studies	18% ± 1%	Explore
adipose	3 studies	42% ± 12%	Explore
kidney	3 studies	29% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	5441.19	2642 / 2642	100%	60.45	705 / 705
esophagus	100%	3936.88	1445 / 1445	100%	35.80	183 / 183
intestine	100%	4723.05	966 / 966	100%	41.45	527 / 527
liver	100%	3056.63	226 / 226	100%	38.32	406 / 406
lung	100%	4736.13	578 / 578	100%	50.82	1155 / 1155
stomach	100%	4045.26	359 / 359	100%	40.51	286 / 286
breast	100%	4808.24	459 / 459	100%	55.32	1117 / 1118
thymus	100%	4285.45	653 / 653	100%	53.76	604 / 605
bladder	100%	5006.76	21 / 21	100%	43.46	503 / 504
uterus	100%	5031.32	170 / 170	100%	45.43	458 / 459
ovary	100%	4036.24	180 / 180	100%	51.06	429 / 430
prostate	100%	3329.53	244 / 245	100%	47.38	502 / 502
skin	100%	4025.45	1809 / 1809	99%	40.49	469 / 472
kidney	100%	3480.73	89 / 89	99%	49.81	895 / 901
pancreas	99%	2250.40	326 / 328	99%	41.78	177 / 178
adrenal gland	100%	4153.07	258 / 258	97%	32.50	224 / 230
adipose	100%	5402.72	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4850.85	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	36.07	29 / 29
muscle	100%	3167.04	803 / 803	0%	0	0 / 0
spleen	100%	3733.16	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	40.03	45 / 45
ureter	0%	0	0 / 0	100%	25.71	1 / 1
heart	100%	3609.09	860 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	27.78	79 / 80
peripheral blood	95%	3847.50	881 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000086	Biological process	G2/M transition of mitotic cell cycle
GO_0045859	Biological process	regulation of protein kinase activity
GO_0016055	Biological process	Wnt signaling pathway
GO_0045737	Biological process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0007283	Biological process	spermatogenesis
GO_0051301	Biological process	cell division
GO_0010508	Biological process	positive regulation of autophagy
GO_0060828	Biological process	regulation of canonical Wnt signaling pathway
GO_0005730	Cellular component	nucleolus
GO_0000307	Cellular component	cyclin-dependent protein kinase holoenzyme complex
GO_0005654	Cellular component	nucleoplasm
GO_0005886	Cellular component	plasma membrane
GO_0000308	Cellular component	cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO_0005634	Cellular component	nucleus
GO_0061575	Molecular function	cyclin-dependent protein serine/threonine kinase activator activity
GO_0019901	Molecular function	protein kinase binding
GO_0016538	Molecular function	cyclin-dependent protein serine/threonine kinase regulator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CCNY
Protein name	Cyclin-Y (Cyc-Y) (Cyclin box protein 1) (Cyclin fold protein 1) (cyclin-X) Cyclin Y
Synonyms	C10orf9 CFP1 CBCP1
Description	FUNCTION: Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. .
Accessions	R4GN48 ENST00000490012.6 ENST00000265375.13 [Q8ND76-3] ENST00000374704.8 [Q8ND76-1] ENST00000339497.7 [Q8ND76-2] Q8ND76 R4GNF3 ENST00000493157.6 ENST00000374706.5 [Q8ND76-3]

CCNY report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review