APOBEC3C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010526Biological processretrotransposon silencing
GO_0051607Biological processdefense response to virus
GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0045071Biological processnegative regulation of viral genome replication
GO_0016554Biological processcytidine to uridine editing
GO_0044355Biological processclearance of foreign intracellular DNA
GO_0070383Biological processDNA cytosine deamination
GO_0009972Biological processcytidine deamination
GO_0044029Biological processpositive regulation of gene expression via chromosomal CpG island demethylation
GO_0045087Biological processinnate immune response
GO_0000932Cellular componentP-body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0004126Molecular functioncytidine deaminase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameAPOBEC3C
Protein nameApolipoprotein B mRNA editing enzyme catalytic subunit 3C
Apolipoprotein B editing enzyme catalytic polypeptide-like 3C
DNA dC->dU-editing enzyme APOBEC-3C (A3C) (EC 3.5.4.38) (APOBEC1-like) (Phorbolin I)
SynonymsPBI
APOBEC1L
DescriptionFUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. .

AccessionsENST00000361441.5
ENST00000428892.1
Q9NRW3
F8WB92
M4VP52