AKIRIN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	21 studies	22% ± 7%	Explore
T cell	16 studies	22% ± 7%	Explore
natural killer cell	16 studies	20% ± 5%	Explore
CD8-positive, alpha-beta T cell	16 studies	21% ± 4%	Explore
endothelial cell	14 studies	23% ± 6%	Explore
regulatory T cell	14 studies	21% ± 4%	Explore
B cell	13 studies	22% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	23% ± 5%	Explore
plasmacytoid dendritic cell	9 studies	25% ± 7%	Explore
gamma-delta T cell	9 studies	28% ± 11%	Explore
oligodendrocyte	9 studies	22% ± 7%	Explore
fibroblast	8 studies	24% ± 7%	Explore
naive B cell	8 studies	23% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	21% ± 6%	Explore
memory B cell	8 studies	21% ± 3%	Explore
smooth muscle cell	7 studies	18% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	23% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	21% ± 4%	Explore
conventional dendritic cell	7 studies	29% ± 18%	Explore
mature NK T cell	7 studies	20% ± 3%	Explore
mucosal invariant T cell	7 studies	25% ± 6%	Explore
epithelial cell	7 studies	36% ± 22%	Explore
ciliated cell	7 studies	33% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	28% ± 6%	Explore
classical monocyte	6 studies	27% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	27% ± 9%	Explore
innate lymphoid cell	6 studies	21% ± 4%	Explore
basal cell	6 studies	26% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	23% ± 6%	Explore
monocyte	5 studies	21% ± 3%	Explore
ionocyte	5 studies	26% ± 7%	Explore
non-classical monocyte	5 studies	30% ± 10%	Explore
connective tissue cell	5 studies	17% ± 2%	Explore
neuron	5 studies	27% ± 13%	Explore
pancreatic A cell	4 studies	39% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	18% ± 2%	Explore
leukocyte	4 studies	24% ± 6%	Explore
precursor B cell	4 studies	31% ± 3%	Explore
myeloid cell	4 studies	27% ± 7%	Explore
astrocyte	4 studies	25% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	29% ± 8%	Explore
macrophage	4 studies	18% ± 1%	Explore
pericyte	4 studies	25% ± 12%	Explore
glutamatergic neuron	4 studies	41% ± 18%	Explore
dendritic cell	4 studies	35% ± 22%	Explore
platelet	4 studies	18% ± 2%	Explore
oligodendrocyte precursor cell	4 studies	26% ± 6%	Explore
T follicular helper cell	4 studies	26% ± 5%	Explore
mast cell	3 studies	23% ± 2%	Explore
type B pancreatic cell	3 studies	33% ± 15%	Explore
exhausted T cell	3 studies	27% ± 11%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 1%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	20% ± 3%	Explore
immature B cell	3 studies	29% ± 11%	Explore
pro-B cell	3 studies	20% ± 0%	Explore
retina horizontal cell	3 studies	21% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	20% ± 2%	Explore
GABAergic neuron	3 studies	37% ± 11%	Explore
abnormal cell	3 studies	30% ± 10%	Explore
enteroendocrine cell	3 studies	25% ± 11%	Explore
goblet cell	3 studies	20% ± 3%	Explore
T-helper 17 cell	3 studies	19% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	24% ± 10%	Explore
lung	7 studies	23% ± 7%	Explore
brain	5 studies	36% ± 8%	Explore
eye	4 studies	19% ± 5%	Explore
pancreas	3 studies	36% ± 15%	Explore
bone marrow	3 studies	17% ± 1%	Explore
uterus	3 studies	25% ± 12%	Explore
intestine	3 studies	25% ± 7%	Explore
liver	3 studies	30% ± 11%	Explore
lymph node	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3746.79	2642 / 2642	100%	115.70	705 / 705
esophagus	100%	3709.11	1445 / 1445	100%	71.39	183 / 183
lung	100%	3367.98	578 / 578	100%	86.01	1155 / 1155
ovary	100%	2402.67	180 / 180	100%	99.10	430 / 430
intestine	100%	4038.03	966 / 966	100%	69.71	526 / 527
breast	100%	2845.14	459 / 459	100%	83.78	1115 / 1118
stomach	100%	3437.69	359 / 359	100%	64.01	285 / 286
prostate	100%	3483.36	245 / 245	99%	77.72	497 / 502
uterus	100%	2920.11	170 / 170	99%	82.57	453 / 459
thymus	100%	3106.01	652 / 653	99%	74.22	598 / 605
bladder	100%	3478.48	21 / 21	98%	70.51	496 / 504
skin	100%	2584.69	1804 / 1809	98%	86.59	462 / 472
pancreas	98%	1421.15	323 / 328	98%	65.50	175 / 178
kidney	100%	3610.12	89 / 89	97%	50.46	870 / 901
adrenal gland	100%	3007.94	258 / 258	94%	60.15	217 / 230
liver	100%	2595.27	226 / 226	93%	41.33	377 / 406
adipose	100%	3380.20	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3598.14	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	87.46	29 / 29
spleen	100%	3460.37	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	68.28	45 / 45
ureter	0%	0	0 / 0	100%	17.16	1 / 1
muscle	99%	2196.56	797 / 803	0%	0	0 / 0
heart	98%	2904.55	847 / 861	0%	0	0 / 0
peripheral blood	96%	3219.03	894 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	86%	41.41	69 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_0010759	Biological process	positive regulation of macrophage chemotaxis
GO_0014839	Biological process	myoblast migration involved in skeletal muscle regeneration
GO_1902723	Biological process	negative regulation of skeletal muscle satellite cell proliferation
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_1902725	Biological process	negative regulation of satellite cell differentiation
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding
GO_0003712	Molecular function	transcription coregulator activity

IV. Literature review

[source]

Gene name	AKIRIN1
Protein name	Akirin 1 (cDNA FLJ54126) Akirin 1 Akirin-1
Synonyms	C1orf108
Description	FUNCTION: Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity). Functions as a signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity). In contrast to AKIRIN2, not involved in nuclear import of proteasomes . .
Accessions	ENST00000446189.6 [Q9H9L7-2] ENST00000372984.8 ENST00000531822.1 Q9H9L7 ENST00000432648.8 [Q9H9L7-1] H0YEQ5 B4DQP0

AKIRIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review