AHSA1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	23 studies	25% ± 9%	Explore
B cell	18 studies	23% ± 7%	Explore
fibroblast	18 studies	24% ± 9%	Explore
ciliated cell	16 studies	45% ± 16%	Explore
CD4-positive, alpha-beta T cell	15 studies	24% ± 9%	Explore
smooth muscle cell	15 studies	22% ± 4%	Explore
CD8-positive, alpha-beta T cell	15 studies	24% ± 7%	Explore
T cell	14 studies	26% ± 9%	Explore
endothelial cell	14 studies	27% ± 9%	Explore
regulatory T cell	13 studies	23% ± 7%	Explore
macrophage	10 studies	26% ± 9%	Explore
pericyte	10 studies	23% ± 6%	Explore
conventional dendritic cell	8 studies	29% ± 14%	Explore
mature NK T cell	8 studies	20% ± 5%	Explore
memory B cell	8 studies	22% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	25% ± 5%	Explore
connective tissue cell	7 studies	23% ± 5%	Explore
epithelial cell	7 studies	38% ± 22%	Explore
basal cell	7 studies	31% ± 11%	Explore
endothelial cell of vascular tree	7 studies	21% ± 4%	Explore
abnormal cell	6 studies	21% ± 3%	Explore
naive B cell	6 studies	24% ± 8%	Explore
gamma-delta T cell	6 studies	34% ± 18%	Explore
plasmacytoid dendritic cell	6 studies	24% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	19% ± 3%	Explore
myofibroblast cell	5 studies	23% ± 4%	Explore
monocyte	5 studies	20% ± 4%	Explore
innate lymphoid cell	5 studies	28% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	26% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	23% ± 6%	Explore
mast cell	5 studies	20% ± 2%	Explore
goblet cell	5 studies	21% ± 7%	Explore
deuterosomal cell	4 studies	23% ± 1%	Explore
retinal ganglion cell	4 studies	55% ± 26%	Explore
precursor B cell	4 studies	33% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	23% ± 7%	Explore
neuron	4 studies	30% ± 15%	Explore
dendritic cell	4 studies	35% ± 18%	Explore
leukocyte	4 studies	32% ± 4%	Explore
pancreatic A cell	3 studies	30% ± 5%	Explore
type B pancreatic cell	3 studies	33% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	3 studies	16% ± 0%	Explore
non-classical monocyte	3 studies	28% ± 6%	Explore
neural crest cell	3 studies	17% ± 1%	Explore
lymphocyte	3 studies	25% ± 12%	Explore
plasma cell	3 studies	40% ± 5%	Explore
immature B cell	3 studies	33% ± 9%	Explore
pro-B cell	3 studies	25% ± 3%	Explore
retina horizontal cell	3 studies	24% ± 7%	Explore
retinal cone cell	3 studies	28% ± 7%	Explore
erythroblast	3 studies	31% ± 19%	Explore
T follicular helper cell	3 studies	22% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
glutamatergic neuron	3 studies	36% ± 16%	Explore
enteroendocrine cell	3 studies	28% ± 14%	Explore
intestinal crypt stem cell	3 studies	22% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 18%	Explore
mucosal invariant T cell	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	9 studies	25% ± 7%	Explore
kidney	5 studies	20% ± 3%	Explore
eye	5 studies	22% ± 5%	Explore
brain	5 studies	25% ± 7%	Explore
intestine	5 studies	22% ± 9%	Explore
peripheral blood	4 studies	23% ± 6%	Explore
liver	4 studies	28% ± 16%	Explore
pancreas	3 studies	31% ± 6%	Explore
uterus	3 studies	26% ± 12%	Explore
prostate	3 studies	24% ± 4%	Explore
lymph node	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4851.37	1445 / 1445	100%	96.38	183 / 183
ovary	100%	4378.16	180 / 180	100%	111.18	430 / 430
prostate	100%	4151.77	245 / 245	100%	137.10	502 / 502
uterus	100%	5088.57	170 / 170	100%	140.29	459 / 459
skin	100%	4369.99	1808 / 1809	100%	141.76	472 / 472
intestine	100%	4851.21	966 / 966	100%	138.32	526 / 527
brain	100%	5202.02	2635 / 2642	100%	111.18	705 / 705
thymus	100%	3462.23	652 / 653	100%	89.45	604 / 605
stomach	100%	3263.26	359 / 359	100%	116.31	285 / 286
adrenal gland	100%	6340.54	258 / 258	100%	133.88	229 / 230
kidney	100%	3677.82	89 / 89	100%	69.99	897 / 901
lung	100%	4197.37	576 / 578	100%	116.43	1153 / 1155
breast	100%	3767.22	459 / 459	99%	124.89	1112 / 1118
bladder	100%	5261.05	21 / 21	99%	135.82	500 / 504
liver	99%	2687.33	223 / 226	100%	73.32	405 / 406
pancreas	98%	1851.79	322 / 328	99%	101.92	177 / 178
eye	0%	0	0 / 0	100%	110.54	80 / 80
lymph node	0%	0	0 / 0	100%	199.53	29 / 29
muscle	100%	5259.39	803 / 803	0%	0	0 / 0
spleen	100%	3796.22	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	110.16	45 / 45
ureter	0%	0	0 / 0	100%	79.05	1 / 1
blood vessel	100%	4460.35	1334 / 1335	0%	0	0 / 0
adipose	100%	4103.26	1203 / 1204	0%	0	0 / 0
heart	97%	4806.82	837 / 861	0%	0	0 / 0
peripheral blood	96%	3781.06	895 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006457	Biological process	protein folding
GO_0032781	Biological process	positive regulation of ATP-dependent activity
GO_0070062	Cellular component	extracellular exosome
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0045296	Molecular function	cadherin binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0005515	Molecular function	protein binding
GO_0001671	Molecular function	ATPase activator activity
GO_0051879	Molecular function	Hsp90 protein binding

IV. Literature review

[source]

Gene name	AHSA1
Protein name	Activator of HSP90 ATPase activity 1 Activator of 90 kDa heat shock protein ATPase homolog 1 (AHA1) (p38)
Synonyms	HSPC322 C14orf3
Description	FUNCTION: Acts as a co-chaperone of HSP90AA1 . Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity . Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins . Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins . .
Accessions	ENST00000553374.5 G3V438 ENST00000556369.1 H0YJ63 ENST00000555133.5 ENST00000216479.8 [O95433-1] G3V3W9 ENST00000555517.1 ENST00000555729.3 ENST00000535854.6 [O95433-2] O95433 H0YJU2 H0YJG7

AHSA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review