UFD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001501Biological processskeletal system development
GO_0032480Biological processnegative regulation of type I interferon production
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0030970Biological processretrograde protein transport, ER to cytosol
GO_0071218Biological processcellular response to misfolded protein
GO_0039536Biological processnegative regulation of RIG-I signaling pathway
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0036501Cellular componentUFD1-NPL4 complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0034098Cellular componentVCP-NPL4-UFD1 AAA ATPase complex
GO_0005634Cellular componentnucleus
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0036435Molecular functionK48-linked polyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUFD1
Protein nameUbiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1)
Ubiquitin fusion degradation 1 like (Yeast), isoform CRA_b (Ubiquitin fusion degradation 1 protein) (Ubiquitin fusion degradation 1-like)
Ubiquitin recognition factor in ER associated degradation 1
Synonymsufd1
UFD1L
hCG_17901
DescriptionFUNCTION: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI . .

AccessionsC9JNP9
Q541A5
C9IZG3
ENST00000421968.6
ENST00000263202.15 [Q92890-2]
ENST00000494054.1
ENST00000447868.5
C9J7C8
C9J6N9
ENST00000474226.1
Q92890
ENST00000399523.5 [Q92890-3]