U2AF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0033120Biological processpositive regulation of RNA splicing
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0000245Biological processspliceosomal complex assembly
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0000243Cellular componentcommitment complex
GO_0005681Cellular componentspliceosomal complex
GO_0016607Cellular componentnuclear speck
GO_0089701Cellular componentU2AF complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0000974Cellular componentPrp19 complex
GO_0071004Cellular componentU2-type prespliceosome
GO_0019899Molecular functionenzyme binding
GO_0030628Molecular functionpre-mRNA 3'-splice site binding
GO_0003723Molecular functionRNA binding
GO_0008187Molecular functionpoly-pyrimidine tract binding
GO_0005515Molecular functionprotein binding
GO_0070742Molecular functionC2H2 zinc finger domain binding
GO_0140678Molecular functionmolecular function inhibitor activity

IV. Literature review

[source]
Gene nameU2AF2
Protein nameSplicing factor U2AF 65 kDa subunit (U2 auxiliary factor 65 kDa subunit) (hU2AF(65)) (hU2AF65) (U2 snRNP auxiliary factor large subunit)
U2 small nuclear RNA auxiliary factor 2
Splicing factor U2AF subunit (U2 snRNP auxiliary factor large subunit)
SynonymsU2AF65
DescriptionFUNCTION: Plays a role in pre-mRNA splicing and 3'-end processing . By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing . Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals . .

FUNCTION: Necessary for the splicing of pre-mRNA. .

AccessionsENST00000450554.6 [P26368-2]
ENST00000308924.9 [P26368-1]
P26368
M0QYQ9
K7ELP8
ENST00000587196.2
B5BU25
ENST00000592874.2