U2AF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	11 studies	28% ± 10%	Explore
B cell	10 studies	33% ± 14%	Explore
endothelial cell	10 studies	47% ± 19%	Explore
fibroblast	9 studies	34% ± 11%	Explore
macrophage	8 studies	30% ± 9%	Explore
T cell	7 studies	30% ± 9%	Explore
CD4-positive, alpha-beta T cell	7 studies	42% ± 23%	Explore
pericyte	7 studies	46% ± 19%	Explore
classical monocyte	6 studies	33% ± 13%	Explore
CD8-positive, alpha-beta T cell	6 studies	46% ± 23%	Explore
regulatory T cell	6 studies	39% ± 13%	Explore
basal cell	5 studies	47% ± 23%	Explore
ciliated cell	5 studies	50% ± 16%	Explore
epithelial cell	5 studies	66% ± 19%	Explore
conventional dendritic cell	5 studies	45% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	35% ± 7%	Explore
plasmacytoid dendritic cell	5 studies	46% ± 17%	Explore
dendritic cell	4 studies	29% ± 8%	Explore
endothelial cell of lymphatic vessel	4 studies	44% ± 19%	Explore
myofibroblast cell	4 studies	36% ± 10%	Explore
non-classical monocyte	4 studies	34% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	41% ± 8%	Explore
plasmablast	3 studies	43% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	36% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	39% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	27% ± 11%	Explore
monocyte	3 studies	30% ± 8%	Explore
pancreatic A cell	3 studies	58% ± 14%	Explore
type B pancreatic cell	3 studies	53% ± 10%	Explore
smooth muscle cell	3 studies	30% ± 8%	Explore
type I pneumocyte	3 studies	35% ± 5%	Explore
type II pneumocyte	3 studies	36% ± 10%	Explore
myeloid cell	3 studies	42% ± 12%	Explore
intestinal crypt stem cell	3 studies	28% ± 14%	Explore
abnormal cell	3 studies	49% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	49% ± 21%	Explore
endothelial cell of vascular tree	3 studies	54% ± 11%	Explore
exhausted T cell	3 studies	49% ± 11%	Explore
intermediate monocyte	3 studies	40% ± 10%	Explore
plasma cell	3 studies	36% ± 7%	Explore
goblet cell	3 studies	51% ± 16%	Explore
connective tissue cell	3 studies	53% ± 8%	Explore
mononuclear phagocyte	3 studies	54% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	4 studies	40% ± 15%	Explore
peripheral blood	4 studies	33% ± 11%	Explore
pancreas	3 studies	58% ± 11%	Explore
intestine	3 studies	40% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	86%	27.14	1239 / 1445	25%	0.37	46 / 183
ovary	89%	43.84	161 / 180	17%	0.25	73 / 430
lung	89%	51.68	514 / 578	6%	0.09	73 / 1155
uterus	92%	36.49	156 / 170	3%	0.03	13 / 459
intestine	89%	38.49	863 / 966	3%	0.04	16 / 527
stomach	87%	31.00	312 / 359	5%	0.08	15 / 286
pancreas	89%	36.09	292 / 328	2%	0.03	4 / 178
bladder	86%	29.95	18 / 21	5%	0.08	26 / 504
spleen	91%	39.16	219 / 241	0%	0	0 / 0
thymus	88%	49.57	575 / 653	3%	0.04	17 / 605
breast	88%	48.12	406 / 459	2%	0.04	25 / 1118
adipose	90%	43.21	1080 / 1204	0%	0	0 / 0
skin	89%	40.90	1603 / 1809	1%	0.01	3 / 472
blood vessel	88%	30.21	1174 / 1335	0%	0	0 / 0
prostate	85%	29.15	208 / 245	1%	0.02	7 / 502
kidney	79%	20.69	70 / 89	5%	0.07	46 / 901
peripheral blood	82%	34.68	763 / 929	0%	0	0 / 0
adrenal gland	78%	21.78	202 / 258	1%	0.01	2 / 230
liver	79%	18.46	178 / 226	0%	0.00	1 / 406
muscle	77%	15.53	616 / 803	0%	0	0 / 0
brain	71%	14.20	1871 / 2642	4%	0.05	26 / 705
heart	72%	15.26	623 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.04	1 / 29
tonsil	0%	0	0 / 0	2%	0.03	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_0015030	Cellular component	Cajal body
GO_0016607	Cellular component	nuclear speck
GO_0089701	Cellular component	U2AF complex
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0005681	Cellular component	spliceosomal complex
GO_0030628	Molecular function	pre-mRNA 3'-splice site binding
GO_0050733	Molecular function	RS domain binding
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	U2AF1
Protein name	U2 small nuclear RNA auxillary factor 1 isoform a Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit) U2 small nuclear RNA auxiliary factor 1
Synonyms	U2AFBP U2AF35 FP793
Description	FUNCTION: Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. .
Accessions	ENST00000459639.5 [Q01081-4] ENST00000291552.9 [Q01081-1] ENST00000486519.5 B5BU08 Q01081 ENST00000380276.6 [Q01081-2] Q7Z780 A0A1B0GW87 ENST00000464750.5 [Q01081-3]

U2AF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review